Mitochondrial control region sequences from northern Greece and Greek Cypriots (original) (raw)

Abstract

Entire mitochondrial control region data were generated for population samples of 319 unrelated individuals from northern Greece and 91 unrelated individuals from Cyprus. The samples from northern Greece have been previously typed for 15 nuclear short tandem repeat (STR; Kovatsi et al., Forensic Sci. Int. 159:61–63, 2006).

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References

  1. Brandstätter A, Peterson C, Irwin J, Mpoke S, Koech D, Parson W, Parsons T (2004) Mitochondrial DNA control region sequences from Nairobi (Kenya): inferring phylogenetic and population genetic parameters for the establishment of a forensic database. Int J Legal Med 118:294–306
    Article PubMed Google Scholar
  2. Brandstätter A, Klein R, Duftner N, Wiegand P, Parson W (2006) Application of a quasi-median network analysis for the visualization of character conflicts to a population sample of mitochondrial DNA control region sequences from southern Germany (Ulm). Int J Legal Med 120:310–314
    Article PubMed Google Scholar
  3. Brandstätter A, Niederstätter H, Pavlic M, Grubwieser P and Parson W (2006) Generating population data for the EMPOP database—an overview of the mtDNA sequencing and data evaluation processes considering 273 Austrian control region sequences as example. Forensic Sci Int 166(2, 3):164-175
    PubMed Google Scholar
  4. Lee HY, Yoo JE, Park MJ, Chung U, Shin KJ (2006) Mitochondrial DNA control region sequences in Koreans: identification of useful variable sites and phylogenetic analysis for mtDNA data quality control. Int J Legal Med 120:5–14
    Article PubMed Google Scholar
  5. Irwin J, Egyed B, Saunier J, Szamosi G, O’Callaghan J, Padar Z, Parsons TJ (2007) Hungarian mtDNA population databases from Budapest and the Baranya county Roma. Int J Legal Med (in press) DOI 10.1007/s00414-006-0128-4
  6. Irwin J, Saunier J, Strouss K, Sturk K, Diegoli T, Just R, Coble M, Parson W Parsons TJ (2007) Development and expansion of high quality control region databases to improve forensic mtDNA evidence interpretation. Forensic Sci Int Genetics (in press) DOI 10.1016/j.fsigen.2007.01.019
  7. Anderson S, Bankier A, Barrell B et al (1981) Sequence and organization of the human mitochondrial genome. Nature 290:457–465
    Article PubMed CAS Google Scholar
  8. Andrews RM, Kubacka I, Chinnery PF, Lightowlers RN, Turnbull DM, Howell N (1999) Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. Nat Genet 23(2):147
    Article PubMed CAS Google Scholar
  9. Wilson M, Allard M, Monson K, Miller K, Budowle B (2002) Recommendations for consistent treatment of length variants in the human mitochondrial control region. Forensic Sci Int 129:35–42
    Article PubMed CAS Google Scholar
  10. Wilson M, Allard M, Monson K, Miller K, Budowle B (2002) Further discussion of the consistent treatment of length variants in the human mitochondrial DNA control region. Forensic Sci Commun 4(4):1–10
    Google Scholar
  11. Bandelt HJ, Parson W (2007) Consistent treatment of length variants in the human mtDNA control region: a reappraisal. Int J Legal Med (in press) DOI 10.1007/s00414-006-0151-5
  12. Schneider S, Roessli D, Excoffier L (2000) Arlequin ver. 2.000: a software for population genetics data analysis. Genetics and Biometry Laboratory, University of Geneva, Switzerland
  13. Helgason A, Sigureth AS, Gulcher JR et al (2000) MtDNA and the origin of the Icelanders: deciphering signals of recent population history. Am J Hum Genet 66(3):999–1016
    Article PubMed CAS Google Scholar
  14. Malyarchuk BA, Grzybowski T, Derenko MV et al (2002) Mitochondrial DNA variability in Poles and Russians. Ann Hum Genet 66(4):261–283
    Article PubMed CAS Google Scholar
  15. Derenko MV, Grzybowski T, Malyarchuk BA et al (2003) Diversity of mitochondrial DNA lineages in south Siberia. Ann Hum Genet 67(5):391–411
    Article PubMed CAS Google Scholar
  16. Derenko MV, Malyarchuk BA, Dambueva IK, Zakharov IA (2003) Structure and diversity of the mitochondrial gene pools of south Siberians. Dokl Biol Sci 393:557–561
    Article PubMed CAS Google Scholar
  17. Malyarchuk BA, Grzybowski T, Derenko MV et al (2003) Mitochondrial DNA variability in Bosnians and Slovenians. Ann Hum Genet 67(5):412–425
    Article PubMed CAS Google Scholar
  18. Reidla M, Kivisild T, Metspalu E et al (2003) Origin and diffusion of mtDNA haplogroup X. Am J Hum Genet 73(5):1178–1190
    Article PubMed CAS Google Scholar
  19. Achilli A, Rengo C, Magri C et al (2004) The molecular dissection of mtDNA haplogroup H confirms that the Franco–Cantabrian glacial refuge was a major source for the European gene pool. Am J Hum Genet 75(5):910–918
    Article PubMed CAS Google Scholar
  20. Loogväli E-L, Roostalu U, Malyarchuk BA et al (2004) Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in Eurasia. Mol Biol Evol 21(11):2012–2021
    Article PubMed Google Scholar
  21. Palanichamy MG, Sun C, Agrawal S et al (2004) Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on complete sequencing: implications for the peopling of south Asia. Am J Hum Genet 75(6):966–978
    Article PubMed CAS Google Scholar
  22. Achilli A, Rengo C, Battaglia V et al (2005) Saami and berbers—an unexpected mitochondrial DNA link. Am J Hum Genet 76(5):883–886
    Article PubMed CAS Google Scholar
  23. Bandelt HJ, Achilli A, Kong QP et al (2005) Low “penetrance” of phylogenetic knowledge in mitochondrial disease studies. Biochem Biophys Res Commun 333(1):122–130
    Article PubMed CAS Google Scholar
  24. Kouvatsi A, Karaiskou N, Apostolidis A, Kirmizidis G (2001) Mitochondrial DNA sequence variation in Greeks. Hum Biol 73(6):855–869
    Article PubMed CAS Google Scholar
  25. Richards M, Macaulay V, Hickey E, Vega E, Sykes B, Guida V, Rengo C et al (2000) Tracing European founder lineages in the Near Eastern mtDNA pool. Am J Hum Genet 67:1251–1276
    Article PubMed CAS Google Scholar
  26. Forster P, Cali C, Röhl A, Metspalu E, D’Anna R, Mirisola M, De Leo G et al (2002) Continental and subcontinental distributions of mtDNA control region types. Int J Legal Med 116:99–108
    Article PubMed Google Scholar

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Acknowledgment

We thank Jennifer O’Callaghan, Heather Williams, Kimberly Watson and Rebecca Just for assistance with data analysis and database confirmation. The opinions and assertions contained herein are solely those of the authors and are not to be construed as official or as views of the US Department of Defense or the US Department of the Army.

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Author notes

  1. Thomas J. Parsons
    Present address: International Commission on Missing Persons, Alipašina 45 A, 71000, Sarajevo, Bosnia and Herzegovina

Authors and Affiliations

  1. Armed Forces DNA Identification Laboratory, Armed Forces Institute of Pathology, Building 101, 1413 Research Boulevard, 20850, Rockville, MD, USA
    Jodi Irwin, Jessica Saunier, Katharine Strouss, Carla Paintner, Toni Diegoli, Kimberly Sturk & Thomas J. Parsons
  2. Laboratory of Forensic Medicine and Toxicology,School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Leda Kovatsi
  3. Institute of Legal Medicine, Innsbruck Medical University, Müllerstrasse 44, 6020, Innsbruck, Austria
    Anita Brandstätter & Walther Parson
  4. Laboratory of Forensic Genetics, The Cyprus Institute of Neurology and Genetics, P.O. Box 23462, 1683, Nicosia, Cyprus
    Marios A. Cariolou

Authors

  1. Jodi Irwin
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  2. Jessica Saunier
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  3. Katharine Strouss
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  4. Carla Paintner
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  5. Toni Diegoli
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  6. Kimberly Sturk
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  7. Leda Kovatsi
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  8. Anita Brandstätter
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  9. Marios A. Cariolou
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  10. Walther Parson
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  11. Thomas J. Parsons
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Corresponding author

Correspondence toJodi Irwin.

Electronic supplementary material

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Figure S1

Map of northern Greece and regions sampled. The number in parentheses represents the sample size from region 1 Grevena (4), 2 Kastoria (6), 3 Kozani (19), 4 Florina (6), 5 Pella (18), 6 Imathia (18), 7 Pieria (17), 8 Kilkis (9), 9 Thessaloniki (147), 10 Halkidiki (14), 11 Serres (29), 12 Drama (14), and 13 Kavala (18) (DOC 45 KB)

Table S1

Entire control region sequences from 91 Greek Cypriots listed as differences from the rCRS, with insertions at polycytosine stretches ignored. Frequency of occurrence of each haplotype is listed, as well as inferred haplogroup attribution, where known (DOC 76 KB)

Table S2

Entire control region sequences from 319 Northern Greeks listed as differences from the rCRS, with insertions at polycytosine stretches ignored. Frequency of occurrence of each haplotype is listed, as well as inferred haplogroup attribution, where known (DOC 202 KB)

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Irwin, J., Saunier, J., Strouss, K. et al. Mitochondrial control region sequences from northern Greece and Greek Cypriots.Int J Legal Med 122, 87–89 (2008). https://doi.org/10.1007/s00414-007-0173-7

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