The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology (original) (raw)

References

1. Ashida K, Katsura T, Motohashi H, Saito H, Inui K (2002) Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells. Am J Physiol 282:G617–G623
   CAS Google Scholar
2. Bailey PD, Boyd CA, Bronk JR, Collier ID, Meredith D, Morgan KM, Temple CS (2000) How to make drugs orally active: a substrate template for peptide transporter PepT1. Angew Chem Int Ed Engl 39:505–508
   Article PubMed Google Scholar
3. Berger UV, Hediger MA (1999) Distribution of peptide transporter PEPT2 mRNA in the rat nervous system. Anat Embryol (Berl) 199:439–449
   Google Scholar
4. Bockman DE, Ganapathy V, Oblak TG, Leibach FH (1997) Localization of peptide transporter in nuclei and lysosomes of the pancreas. Int J Pancreat 22:221–225
   CAS PubMed Google Scholar
5. Bolger MB, Haworth IS, Yeung AK, Ann D, von Grafenstein H, Hamm Alvarez S, Okamoto CT, Kim KJ, Basu SK, Wu S, Lee VHL (1998) Structure, function, and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1. J Pharm Sci 87:1286–1291
   Article CAS PubMed Google Scholar
6. Boll M, Herget M, Wagener M, Weber WM, Markovich D, Biber J, Clauss W, Murer H, Daniel H (1996) Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Proc Natl Acad Sci USA 93:284–289
   Article CAS PubMed Google Scholar
7. Boll M, Markovich D, Weber WM, Korte H, Daniel H, Murer H (1994) Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors. Pflugers Arch 429:146–149
   CAS PubMed Google Scholar
8. Botka CW, Wittig TW, Graul RC, Nielsen CU, Higaka K, Amidon GL, Sadee W (2000) Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. AAPS PharmSci 2:E16
   CAS PubMed Google Scholar
9. Buyse M, Tsocas A, Walker F, Merlin D, Bado A (2002) PepT1-mediated fMLP transport induces intestinal inflammation in vivo. Am J Physiol 283:C1795–C1800
   CAS Google Scholar
10. Chen XZ, Steel A, Hediger MA (2000) Functional roles of histidine and tyrosine residues in the H+-peptide transporter PepT1. Biochem Biophys Res Commun 272:726–730
    Article CAS PubMed Google Scholar
11. Chen XZ, Zhu T, Smith DE, Hediger MA (1999) Stoichiometry and kinetics of the high-affinity H+-coupled peptide transporter PepT2. J Biol Chem 274:2773–2779
    Article CAS PubMed Google Scholar
12. Covitz KMY, Amidon GL, Sadee W (1998) Membrane topology of the human dipeptide transporter, hPEPT1, determined by epitope insertions. Biochemistry 37:15214–15221
    Article CAS PubMed Google Scholar
13. Dantzig AH (1997) Oral absorption of beta-lactams by intestinal peptide transport proteins. Adv Drug Deliv Rev 23:63–76
    Article CAS Google Scholar
14. Doring F, Dorn D, Bachfischer U, Amasheh S, Herget M, Daniel H (1996) Functional analysis of a chimeric mammalian peptide transporter derived from the intestinal and renal isoforms. J Physiol (Lond) 497:773–779
    Google Scholar
15. Doring F, Walter J, Will J, Focking M, Boll M, Amasheh S, Clauss W, Daniel H (1998) Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J Clin Invest 101:2761–2767
    CAS PubMed Google Scholar
16. Doring F, Will J, Amasheh S, Clauss W, Ahlbrecht H, Daniel H (1998) Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter. J Biol Chem 273:23211–23218
    Article CAS PubMed Google Scholar
17. Dringen R, Hamprecht B, Broer S (1998) The peptide transporter PepT2 mediates the uptake of the glutathione precursor CysGly in astroglia-rich primary cultures. J Neurochem 71:388–393
    CAS PubMed Google Scholar
18. Ezra A, Hoffman A, Breuer E, Alferiev IS, Monkkonen J, El Hanany-Rozen N, Weiss G, Stepensky D, Gati I, Cohen H, Tormalehto S, Amidon GL, Golomb G (2000) A peptide prodrug approach for improving bisphosphonate oral absorption. J Med Chem 43:3641–3652
    Article CAS PubMed Google Scholar
19. Fei YJ, Kanai Y, Nussberger S, Ganapathy V, Leibach FH, Romero MF, Singh SK, Boron WF, Hediger MA (1994) Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368:563–566
    Google Scholar
20. Fei YJ, Liu JC, Fujita T, Liang R, Ganapathy V, Leibach FH (1998) Identification of a potential substrate binding domain in the mammalian peptide transporters PEPT1 and PEPT2 using PEPT1-PEPT2 and PEPT2-PEPT1 chimeras. Biochem Biophys Res Commun 246:39–44
    Article CAS PubMed Google Scholar
21. Fei YJ, Liu W, Prasad PD, Kekuda R, Oblak TG, Ganapathy V, Leibach FH (1997) Identification of the histidyl residue obligatory for the catalytic activity of the human H+/peptide cotransporters PEPT1 and PEPT2. Biochemistry 36:452–460
    Article CAS PubMed Google Scholar
22. Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH (1995) Differential recognition of beta-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem 270:25672–25677
    Article CAS PubMed Google Scholar
23. Gangopadhyay A, Thamotharan M, Adibi SA (2002) Regulation of oligopeptide transporter (Pept-1) in experimental diabetes. Am J Physiol 283:G133–G138
    CAS Google Scholar
24. Groneberg DA, Doring F, Theis S, Nickolaus M, Fischer A, Daniel H (2002) Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein. Am J Physiol 282:E1172–E1179
    CAS Google Scholar
25. Groneberg DA, Nickolaus M, Springer J, Doring F, Daniel H, Fischer A (2001) Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake. Am J Pathol 158:707–714
    Google Scholar
26. Hussain I, Zanic-Grubisic T, Kudo Y, Boyd CA (2001) Functional and molecular characterization of a peptide transporter in the rat PC12 neuroendocrine cell line. FEBS Lett 508:350–354
    Article CAS PubMed Google Scholar
27. Ihara T, Tsujikawa T, Fujiyama Y, Bamba T (2000) Regulation of PepT1 peptide transporter expression in the rat small intestine under malnourished conditions. Digestion 61:59–67
    Article CAS PubMed Google Scholar
28. Kelty CJ, Brown NJ, Reed MW, Ackroyd R (2002) The use of 5-aminolaevulinic acid as a photosensitiser in photodynamic therapy and photodiagnosis. Photochem Photobiol Sci 1:158–168
    Article CAS PubMed Google Scholar
29. Knutter I, Rubio-Aliaga I, Boll M, Hause G, Daniel H, Neubert K, Brandsch M (2002) H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1. Am J Physiol 283:G222–G229
    CAS Google Scholar
30. Knutter I, Theis S, Hartrodt B, Born I, Brandsch M, Daniel H, Neubert K (2001) A novel inhibitor of the mammalian peptide transporter PEPT1. Biochemistry 40:4454–4458
    Article CAS PubMed Google Scholar
31. Kottra G, Daniel H (2001) Bidirectional electrogenic transport of peptides by the proton-coupled carrier PEPT1 in Xenopus laevis oocytes: its asymmetry and symmetry. J Physiol (Lond) 536:495–503
    Google Scholar
32. Kottra G, Stamfort A, Daniel H (2002) PEPT1 as a paradigm for membrane carriers that mediate electrogenic bidirectional transport of anionic, cationic, and neutral substrates. J Biol Chem 277:32683–32691
    Article CAS PubMed Google Scholar
33. Lee VH, Chu C, Mahlin ED, Basu SK, Ann DK, Bolger MB, Haworth IS, Yeung AK, Wu SK, Hamm-Alvarez S, Okamoto CT (1999) Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1. J Control Release 62:129–140
    Article CAS PubMed Google Scholar
34. Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH (1995) Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem 270:6456–6463
    CAS PubMed Google Scholar
35. Liu W, Liang R, Ramamoorthy S, Fei YJ, Ganapathy ME, Hediger MA, Ganapathy V, Leibach FH (1995) Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney. Biochim Biophys Acta 1235:461–466
    Article CAS PubMed Google Scholar
36. Mackenzie B, Fei YJ, Ganapathy V, Leibach FH (1996) The human intestinal H+/oligopeptide cotransporter hPEPT1 transports differently-charged dipeptides with identical electrogenic properties. Biochim Biophys Acta 1284:125–128
    Article CAS PubMed Google Scholar
37. Mackenzie B, Loo DD, Fei Y, Liu WJ, Ganapathy V, Leibach FH, Wright EM (1996) Mechanisms of the human intestinal H+-coupled oligopeptide transporter hPEPT1. J Biol Chem 271:5430–5437
    CAS PubMed Google Scholar
38. Merlin D, Si-Tahar M, Sitaraman SV, Eastburn K, Williams I, Liu X, Hediger MA, Madara JL (2001) Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: transport of bacterial peptides influences expression of MHC class 1 molecules. Gastroenterology 120:1666–1679
    Google Scholar
39. Neumann J, Brandsch M (2003) Delta-aminolevulinic acid transport in cancer cells of the human extrahepatic biliary duct. J Pharmacol Exp Ther 305:219–224
    Article CAS PubMed Google Scholar
40. Ogihara H, Saito H, Shin BC, Terada T, Takenoshita S, Nagamachi Y, Inui K, Takata K (1996) Immuno-localization of H+/peptide cotransporter in rat digestive tract. Biochem Biophys Res Commun 220:848–852
    Article CAS PubMed Google Scholar
41. Pan X, Terada T, Irie M, Saito H, Inui K (2002) Diurnal rhythm of H+-peptide cotransporter in rat small intestine. Am J Physiol 283:G57–G64
    CAS Google Scholar
42. Ramamoorthy S, Liu W, Ma YY, Yang-Feng TL, Ganapathy V, Leibach FH (1995) Proton/peptide cotransporter (PEPT 2) from human kidney: functional characterization and chromosomal localization. Biochim Biophys Acta 1240:1–4
    Article CAS PubMed Google Scholar
43. Rubio-Aliaga I, Boll M, Daniel H (2000) Cloning and characterization of the gene encoding the mouse peptide transporter PEPT2. Biochem Biophys Res Commun 276:734–741
    Article CAS PubMed Google Scholar
44. Rubio-Aliaga I, Frey I, Boll M, Groneberg DA, Eichinger HM, Balling R, Daniel H (2003) Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney. Mol Cell Biol 23:3247–3252
    Article CAS PubMed Google Scholar
45. Saito H, Motohashi H, Mukai M, Inui K (1997) Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1. Biochem Biophys Res Commun 237:577–582
    Article CAS PubMed Google Scholar
46. Saito H, Okuda M, Terada T, Sasaki S, Inui K (1995) Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther 275:1631–1637
    Google Scholar
47. Saito H, Terada T, Okuda M, Sasaki S, Inui K (1996) Molecular cloning and tissue distribution of rat peptide transporter PEPT2. Biochim Biophys Acta 1280:173–177
    Article CAS PubMed Google Scholar
48. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M (2001) Cloning of a lymphatic peptide/histidine transporter. Biochem J 356:53–60
    Article CAS PubMed Google Scholar
49. Sawada K, Terada T, Saito H, Hashimoto Y, Inui K (1999) Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2. Br J Pharmacol 128:1159–1164
    CAS PubMed Google Scholar
50. Shen H, Smith DE, Keep RF, Xiang J, Brosius FC (2003) Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus. J Biol Chem 278:4786–4791
    Article CAS PubMed Google Scholar
51. Shen H, Smith DE, Yang T, Huang YG, Schnermann JB, Brosius FC (1999) Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney. Am J Physiol 276:F658–F665
    CAS PubMed Google Scholar
52. Shu C, Shen H, Hopfer U, Smith DE (2001) Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures. Drug Metab Dispos 29:1307–1315
    CAS PubMed Google Scholar
53. Shu C, Shen H, Teuscher NS, Lorenzi PJ, Keep RF, Smith DE (2002) Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture. J Pharmacol Exp Ther 301:820–829
    Article CAS PubMed Google Scholar
54. Smith DE, Pavlova A, Berger UV, Hediger MA, Yang TX, Huang YNG, Schnermann JB (1998) Tubular localization and tissue distribution of peptide transporters in rat kidney. Pharm Res 15:1244–1249
    Article CAS PubMed Google Scholar
55. Steel A, Nussberger S, Romero MF, Boron WF, Boyd CAR, Hediger MA (1997) Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepT1. J Physiol (Lond) 498:563–569
    Google Scholar
56. Steiner HY, Naider F, Becker JM (1995) The PTR family: a new group of peptide transporters. Mol Microbiol 16:825–834
    CAS PubMed Google Scholar
57. Takahashi K, Masuda S, Nakamura N, Saito H, Futami T, Doi T, Inui K (2001) Upregulation of H+-peptide cotransporter PEPT2 in rat remnant kidney. Am J Physiol 281:F1109–F1116
    CAS Google Scholar
58. Tamai I, Nakanishi T, Nakahara H, Sai Y, Ganapathy V, Leibach FH, Tsuji A (1998) Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1. J Pharm Sci 87:1542–1546
    Article CAS PubMed Google Scholar
59. Terada T, Saito H, Mukai M, Inui K (1996) Identification of the histidine residues involved in substrate recognition by a rat H+/peptide cotransporter, PEPT1. FEBS Lett 394:196–200
    Article CAS PubMed Google Scholar
60. Terada T, Saito H, Mukai M, Inui K (1997) Characterization of stably transfected kidney epithelial cell line expressing rat H+/peptide cotransporter PEPT1: localization of PEPT1 and transport of beta-lactam antibiotics. J Pharmacol Exp Ther 281:1415–1421
    Google Scholar
61. Terada T, Saito H, Sawada K, Hashimoto Y, Inui K (2000) N-terminal halves of rat H+/peptide transporters are responsible for their substrate recognition. Pharm Res 17:15–20
    Article CAS PubMed Google Scholar
62. Terada T, Sawada K, Irie M, Saito H, Hashimoto Y, Inui K (2000) Structural requirements for determining the substrate affinity of peptide transporters PEPT1 and PEPT2. Pflugers Arch 440:679–684
    Article CAS PubMed Google Scholar
63. Terada T, Sawada K, Saito H, Hashimoto Y, Inui K (1999) Functional characteristics of basolateral peptide transporter in the human intestinal cell line Caco-2. Am J Physiol 276:G1435–G1441
    CAS PubMed Google Scholar
64. Terada T, Sawada K, Saito H, Hashimoto Y, Inui K (2000) Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. Eur J Pharmacol 392:11–17
    Article CAS PubMed Google Scholar
65. Thamotharan M, Bawani SZ, Zhou X, Adibi SA (1999) Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast. Metabolism 48:681–684
    CAS PubMed Google Scholar
66. Theis S, Knutter I, Hartrodt B, Brandsch M, Kottra G, Neubert K, Daniel H (2002) Synthesis and characterization of high affinity inhibitors of the H+/peptide transporter PEPT2. J Biol Chem 277:7287–7292
    Article CAS PubMed Google Scholar
67. Thwaites DT, Kennedy DJ, Raldua D, Anderson CM, Mendoza ME, Bladen CL, Simmons NL (2002) H/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na/H exchanger. Gastroenterology 122:1322–1333
    Google Scholar
68. Tsuji A (1999) Tissue selective drug delivery utilizing carrier-mediated transport systems. J Control Release 62:239–244
    Article CAS PubMed Google Scholar
69. Urtti A, Johns SJ, Sadee W (2001) Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant. AAPS PharmSci 3:E6
    CAS PubMed Google Scholar
70. Watanabe K, Sawano T, Terada K, Endo T, Sakata M, Sato J (2002) Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2. Biol Pharm Bull 25:885–890
    Article CAS PubMed Google Scholar
71. Wenzel U, Diehl D, Herget M, Kuntz S, Daniel H (1999) Regulation of the high-affinity H+/peptide cotransporter in renal LLC-PK1 cells. J Cell Physiol 178:341–348
    Article CAS PubMed Google Scholar
72. Wenzel U, Kuntz S, Diestel S, Daniel H (2002) PEPT1-mediated cefixime uptake into human intestinal epithelial cells is increased by Ca2+ channel blockers. Antimicrob Agents Chemother 46:1375–1380
    Article CAS PubMed Google Scholar
73. Yamashita T, Shimada S, Guo W, Sato K, Kohmura E, Hayakawa T, Takagi T, Tohyama M (1997) Cloning and functional expression of a brain peptide/histidine transporter. J Biol Chem 272:10205–10211
    Article CAS PubMed Google Scholar
74. Yeung AK, Basu SK, Wu SK, Chu C, Okamoto CT, HammAlvarez SF, von Grafenstein H, Shen WC, Kim KJ, Bolger MB, Haworth IS, Ann DK, Lee VHL (1998) Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton-coupled dipeptide transporter (hPepT1). Biochem Biophys Res Commun 250:103–107
    Article CAS PubMed Google Scholar
75. Zhou X, Thamotharan M, Gangopadhyay A, Serdikoff C, Adibi SA (2000) Characterization of an oligopeptide transporter in renal lysosomes. Biochim Biophys Acta 1466:372–378
    Article CAS PubMed Google Scholar
76. Zhu T, Chen XZ, Steel A, Hediger MA, Smith DE (2000) Differential recognition of ACE inhibitors in Xenopus laevis oocytes expressing rat PEPT1 and PEPT2. Pharm Res 17:526–532
    Article CAS PubMed Google Scholar
77. Ziegler TR, Fernandez-Estivariz C, Gu LH, Bazargan N, Umeakunne K, Wallace TM, Diaz EE, Rosado KE, Pascal RR, Galloway JR, Wilcox JN, Leader LM (2002) Distribution of the H+/peptide transporter PepT1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome. Am J Clin Nutr 75:922–930
    CAS PubMed Google Scholar

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