- Ahima RS, Flier JS (2000) Adipose tissue as an endocrine organ. Trends Endocrinol Metab 11:327–332
Article PubMed CAS Google Scholar
- Alvarez-Llamas G, Szalowska E, de Vries MP, Weening D, Landman K, Hoek A, Wolffenbuttel BH, Roelofsen H, Vonk RJ (2007) Characterization of the human visceral adipose tissue secretome. Mol Cell Proteomics 6:589–600
Article PubMed CAS Google Scholar
- Aoki N, Jin-no S, Nakagawa Y, Asai N, Arakawa E, Tamura N, Tamura T, Matsuda T (2007) Identification and characterization of microvesicles secreted by 3T3–L1 adipocytes: redox- and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles. Endocrinology 148:3850–3862
Article PubMed CAS Google Scholar
- Bulló M, Garcia-Lorda P, Megias I, Salas-Salvado J (2003) Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes Res 11:525–531
Article PubMed Google Scholar
- Cancello R, Tordjman J, Poitou C, Guilhem G, Bouillot JL, Hugol D, Coussieu C, Basdevant A, Hen AB, Bedossa P, Guerre-Millo M, Clément K (2006) Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 55:1554–1561
Article PubMed CAS Google Scholar
- Chavey C, Mari B, Monthouel MN, Bonnafous S, Anglard P, Van Obberghen E, Tartare-Deckert S (2003) Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J Biol Chem 278:11888–11896
Article PubMed CAS Google Scholar
- Chizzolini C, Rezzonico R, De Luca C, Burger D, Dayer JM (2000) Th2 cell membrane factors in association with IL-4 enhance matrix metalloproteinase-1 (MMP-1) while decreasing MMP-9 production by granulocyte-macrophage colony-stimulating factor-differentiated human monocytes. J Immunol 164:5952–5960
PubMed CAS Google Scholar
- Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, Obin MS (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46:2347–2355
Article PubMed CAS Google Scholar
- Constant V, Gagnon A, Landry A, Sorisky A (2006) Macrophage-conditioned medium inhibits the differentiation of 3T3–L1 and human abdominal preadipocytes. Diabetologia 49:1402–1411
Article PubMed CAS Google Scholar
- Croissandeau G, Chrétien M, Mbikay M (2002) Involvement of matrix metalloproteinases in the adipose conversion of 3T3–L1 preadipocytes. Biochem J 364:739–746
Article PubMed CAS Google Scholar
- Curat C, Wegner V, Sengenѐs C, Miranville A, Tonus C, Busse R, Bouloumié A (2006) Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia 49:744–747
Article PubMed CAS Google Scholar
- Derosa G, Ferrari I, D'Angelo A, Tinelli C, Salvadeo SA, Ciccarelli L, Piccinni MN, Gravina A, Ramondetti F, Maffioli P, Cicero AF (2008) Matrix metalloproteinase-2 and -9 levels in obese patients. Endothelium 15:219–224
Article PubMed CAS Google Scholar
- Do MS, Nam SY, Hong SE, Kim KW, Duncan JS, Beattie JH, Trayhurn P (2002) Metallothionein gene expression in human adipose tissue from lean and obese subjects. Horm Metab Res 34:348–351
Article PubMed CAS Google Scholar
- Engström G, Hedblad B, Stavenow L, Lind P, Janzon L, Lindgarde F (2003) Inflammation-sensitive plasma proteins are associated with future weight gain. Diabetes 52:2097–2101
Article PubMed Google Scholar
- Festa A, D'Agostino R, Williams K, Karter AJ, Mayer-Davis EJ, Tracy RP, Haffner SM (2001) The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes 25:1407–1415
Article CAS Google Scholar
- Guerre-Millo M (2002) Adipose tissue hormones. J Endocrinol Investig 25:855–861
CAS Google Scholar
- Hausman GJ, Poulos SP, Richardson RL, Barb CR, Andacht T, Kirk HC, Mynatt RL (2006) Secreted proteins and genes in fetal and neonatal pig adipose tissue and stromal-vascular cells. J Anim Sci 84:1666–1681
Article PubMed CAS Google Scholar
- Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Harada N, Hosaka T, Nakaya Y, Ishidoh K, Obata T, Ebina Y, Gu H, Takeda S, Kishi K, Nikawa T (2007) Deficiency of CBL-B gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes 56:2511–2522
Article PubMed CAS Google Scholar
- Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860–867
Article PubMed CAS Google Scholar
- Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor-necrosis-factor-α—direct role in obesity-linked insulin resistance. Science 259:87–91
Article PubMed CAS Google Scholar
- Karmakar S, Das C (2002) Regulation of trophoblast invasion by IL-1β and TGF-β1. Am J Reprod Immunol 48:210–219
Article PubMed Google Scholar
- Kawamura T, Murakami K, Bujo H, Unoki H, Jiang M, Nakayama T, Saito Y (2008) Matrix metalloproteinase-3 enhances the free fatty acids-induced VEGF expression in adipocytes through toll-like receptor 2. Exp Biol Med 233:1213–1221
Article CAS Google Scholar
- Klatt AR, Klinger G, Neumuller O, Eidenmuller B, Wagner I, Achenbach T, Aigner T, Bartnik E (2006) TAK1 downregulation reduces IL-1β induced expression of MMP13, MMP1 and TNF-α. Biomed Pharmacother 60:55–61
Article PubMed CAS Google Scholar
- Lacasa D, Taleb S, Keophiphath M, Miranville A, Clément K (2007) Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 148:868–877
Article PubMed CAS Google Scholar
- Lumeng CN, Deyoung SM, Saltiel AR (2007) Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metabol 292:E166–E174
Article CAS Google Scholar
- Maquoi E, Munaut C, Colige A, Collen D, Lijnen HR (2002) Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes 51:1093–1101
Article PubMed CAS Google Scholar
- Mazzatti DJ, Smith MA, Oita RC, Lim FL, White AJ, Reid MB (2008) Muscle unloading-induced metabolic remodeling is associated with acute alterations in PPARδ and UCP-3 expression. Physiol Genomics 34:149–161
Article PubMed CAS Google Scholar
- Page-McCaw A, Ewald AJ, Werb Z (2007) Matrix metalloproteinases and the regulation of tissue remodelling. Nature Rev Mol Cell Biol 8:221–233
Article CAS Google Scholar
- Permana PA, Menge C, Reaven PD (2006) Macrophage-secreted factors induce adipocyte inflammation and insulin resistance. Biochem Biophys Res Commun 341:507–514
Article PubMed CAS Google Scholar
- Rajala MW, Scherer PE (2003) The adipocyte—at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144:3765–3773
Article PubMed CAS Google Scholar
- Rennie KL, Jebb SA (2005) Prevalence of obesity in Great Britain. Obes Rev 6:11–12
Article PubMed CAS Google Scholar
- Rifas L, Fausto A, Scott MJ, Avioli LV, Welgus HG (1994) Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis. Endocrinology 134:213–221
Article PubMed CAS Google Scholar
- Rosen ED, Spiegelman BM (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444:847–853
Article PubMed CAS Google Scholar
- Sampieri CL, Nuttall RK, Young DA, Goldspink D, Clark IM, Edwards DR (2008) Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes. Matrix Biol 27:128–138
Article PubMed CAS Google Scholar
- Suganami T, Nishida J, Ogawa Y (2005) A paracrine loop between adipocytes and macrophages aggravates inflammatory changes—role of free fatty acids and tumor necrosis factor α. Arterioscler Thromb Vasc Biol 25:2062–2068
Article PubMed CAS Google Scholar
- Sundström C, Nilsson K (1976) Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 17:565–577
Article PubMed Google Scholar
- Trayhurn P, Beattie JH (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 60:329–339
Article PubMed CAS Google Scholar
- Trayhurn P, Duncan JS, Wood AM, Beattie JH (2000) Metallothionein gene expression and secretion in white adipose tissue. Am J Physiol Regul Integr Comp Physiol 279:R2329–R2335
PubMed CAS Google Scholar
- Trayhurn P, Duncan JS, Wood AM, Beattie JH (2000) Regulation of metallothionein gene expression and secretion in rat adipocytes differentiated from preadipocytes in primary culture. Horm Metab Res 32:542–547
Article PubMed CAS Google Scholar
- Trayhurn P, Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347–355
Article PubMed CAS Google Scholar
- Trayhurn P, Wood IS (2005) Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33:1078–1081
Article PubMed CAS Google Scholar
- van Beek EA, Bakker AH, Kruyt PM, Vink C, Saris WH, Franssen-van Hal NLW, Keijer J (2008) Comparative expression analysis of isolated human adipocytes and the human adipose cell lines LiSa-2 and PAZ6. Int J Obes 32:912–921
Article CAS Google Scholar
- Wabitsch M, Brenner RE, Melzner I, Braun M, Moller P, Heinze E, Debatin KM, Hauner H (2001) Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes 25:8–15
Article CAS Google Scholar
- Wang B, Jenkins JR, Trayhurn P (2005) Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-α. Am J Physiol Endocrinol Metab 288:E731–E740
Article PubMed CAS Google Scholar
- Wang B, Trayhurn P (2006) Acute and prolonged effects of TNF-alpha on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture. Pflügers Arch Eur J Physiol 452:418–427
Article CAS Google Scholar
- Wang B, Wood IS, Trayhurn P (2008) PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes. Biochem Biophys Res Commun 368:88–93
Article PubMed CAS Google Scholar
- Watari M, Watari H, DiSanto ME, Chacko S, Shi GP, Strauss JF 3rd (1999) Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cells. Am J Pathol 154:1755–1762
PubMed CAS Google Scholar
- Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808
PubMed CAS Google Scholar
- Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821–1830
PubMed CAS Google Scholar
- Yamashita A, Soga Y, Iwamoto Y, Asano T, Li Y, Abiko Y, Nishimura F (2008) DNA microarray analyses of genes expressed differentially in 3T3–L1 adipocytes co-cultured with murine macrophage cell line RAW264.7 in the presence of the toll-like receptor 4 ligand bacterial endotoxin. Int J Obesity 32:1725–1729 2005
Article CAS Google Scholar
- Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW (1999) C-reactive protein in wealthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction—a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19:972–978
PubMed CAS Google Scholar
- Zhang YY, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homolog. Nature 372:425–432
Article PubMed CAS Google Scholar