Short-term effects of glucagon-like peptide 1 (GLP-1) receptor agonists on fat distribution in patients with type 2 diabetes mellitus: an ultrasonography study (original) (raw)

References

  1. Jendle J, Nauck MA, Matthews DR, Frid A, Hermansen K, Düring M, Zdravkovic M, Strauss BJ, Garber AJ, on the behalf of the LEAD-2 and LEAD-3 Study Groups (2009) Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue. Diabetes Obes Metab 11:1163–1172
    Article CAS PubMed Google Scholar
  2. De Fronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD (2005) Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 28:1092–1100
    Article Google Scholar
  3. Kim D, MacConell L, Zhuang D, Kothare PA, Trautman M, Fineman M, Taylor K (2007) Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. Diabetes Care 30:1487–1493
    Article CAS PubMed Google Scholar
  4. Vilsbøll T, Zdravkovic M, Le-Thi T, Krarup T, Schmitz O, Courreges JP, Verhoeven R, Buganova I, Madsbad S (2007) Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes. Diabetes Care 30:1608–1610
    Article PubMed Google Scholar
  5. Vilsbøll T, Christensen M, Junker AE, Knop FK, Gluud LL (2012) Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analysis of randomised controlled trials. BMJ 344:d7771. doi:10.1136/bmj.d7771
    Article PubMed Central PubMed Google Scholar
  6. Williamson DF, Pamuk E, Thun M, Flanders D, Byers T, Heath C (1995) Prospective study of intentional weight loss and mortality in never-smoking overweight US white women aged 40–64 years. Am J Epidemiol 141:1128–1141
    CAS PubMed Google Scholar
  7. Chaston TB, Dixon JB (2008) Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: findings from a systemic review. Int J Obes 32:619–628
    Article CAS Google Scholar
  8. Després JP (2011) Excess visceral adipose tissue/ectopic fat. J Am Coll Cardiol 57:1887–1889
    Article PubMed Google Scholar
  9. Bazzocchi A, Diano D, Ponti F, Salizzoni E, Albisinni U, Marchesini G, Battista G (2014) A 360-degree overview of body composition in healthy people: relationships among anthropometry, ultrasonography, and dual-energy x-ray absorptiometry. Nutrition 30:696–701
    Article PubMed Google Scholar
  10. Kawai T, Kamide K, Onishi M, Yamamoto-Hanasaki H, Baba Y, Hongyo K, Shimaoka I, Tatara Y, Takeya Y, Ohishi M, Rakugi H (2011) Usefulness of the resistive index in renal Doppler ultrasonography as an indicator of vascular damage in patients with risks of atheroscerosis. Nephrol Dial Transplant 26:3256–3262
    Article PubMed Google Scholar
  11. Società Italiana di Diabetologia—Associazione Medici Diabetologi (2014) Standard italiani per la cura del diabete mellito. http://www.standarditaliani.it
  12. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604–612
    Article PubMed Central PubMed Google Scholar
  13. Suzuki R, Watanabe S, Hirai Y, Akiyama K, Nishide T, Matsushima Y, Murayama H, Ohshima H, Shinomiya M, Shirai K, Saito Y, Yoshida S, Saisho H, Ohto M (1993) Abdominal wall fat index, estimated by ultrasonography, for assessment of the ratio of visceral fat to subcutaneous fat in the abdomen. Am J Med 95:309–314
    Article CAS PubMed Google Scholar
  14. Kawasaki S, Aoki K, Hasegawa O, Numata K, Tanaka K, Shibata N, Shimada S, Okamura A, Terauchi Y (2008) Sonographic evaluation of visceral fat by measuring para- and perirenal fat. J Clin Ultrasound 36:129–133
    Article PubMed Google Scholar
  15. Sabir N, Sermez Y, Kazil S, Zencir M (2001) Correlation of abdominal fat accumulation and liver steatosis: importance of ultrasonographic and anthropometric measurements. Eur J Ultrasound 14:121–128
    Article CAS PubMed Google Scholar
  16. Sperandeo M, Varriale A, D’Amico G, Sperandeo G, Piattelli ML, De Cata A, Greco A, Prigigallo F, Annese MA, Cedrone L, Vendemiale G (2007) Intrarenal resistive index in patients with type 2 diabetes mellitus with and without microalbuminuria. Eur J Inflamm 5:103–110
    Google Scholar
  17. Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, Di Mario U, Leonetti F (2003) Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 88:5163–5168
    Article CAS PubMed Google Scholar
  18. Sperandeo M, Carnevale V, Muscarella S, Sperandeo G, Varriale A, Filabozzi P, Piattelli ML, D’Alessandro V, Copetti M, Pellegrini F, Dimitri L, Vendemiale G (2011) Clinical application of transthoracic ultrasonography in patients with pneumonia. Eur J Clin Invest 41:1–7
    Article PubMed Google Scholar
  19. Bagger JI, Christensen M, Knop FK, Vilsbøl T (2011) Therapy for obesity based on gastrointestinal hormones. Rev Diabet Stud 8:339–347
    Article PubMed Central PubMed Google Scholar
  20. Holst JJ, Deacon CF (2013) Is there a place for incretin therapies in obesity and prediabetes? Trends Endocrinol Metab 24:145–152
    Article CAS PubMed Google Scholar
  21. Sever MJ, Kocjan T, Pfeifer M, Kravos NA, Janez A (2014) Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin. Eur J Endocrinol 170:451–459
    Article CAS Google Scholar
  22. Tchernof A, Despres JP (2013) Pathophysiology of human visceral obesity: an update. Physiol Rev 93:359–404
    Article CAS PubMed Google Scholar
  23. Bartelt A, Heeren J (2014) Adipose tissue browning and metabolic health. Nat Rev Endocrinol 10:24–36
    Article CAS PubMed Google Scholar
  24. Liu KH, Chan JL, Chan WB, Chan JCN, Chu CWW (2006) Mesenteric fat thickness is an independent determinant of metabolic syndrome and identifies subjects with increased carotid intima-media thickness. Diabetes Care 29:379–384
    Article PubMed Google Scholar
  25. Liu J, Fox CS, Hickson DA, May WD, Hairston KG, Carr JJ, Taylor HA (2010) Impact of abdominal visceral and subcutaneous adipose tissue on cardiometabolic risk factors: the Jackson Heart Study. J Clin Endocrinol Metab 95:5419–5426
    Article CAS PubMed Central PubMed Google Scholar
  26. Cetin DC, Nasr G (2014) Obesity in the elderly: more complicated than you think. Clev Clin J Med 81:51–61
    Article Google Scholar
  27. Christensen DL, Faurholt-Jepsen D, Faerch K, Mwaniki DL, Boit MK, Kilonzo B, Tetens I, Friis H, Borch-Johnsen K (2014) Insulin resistance and beta-cell function in different ethnic groups in Kenya: the role of abdominal fat distribution. Acta Diabetol 51:53–60
    Article CAS PubMed Google Scholar
  28. The Emerging Risk Factors Collaboration (2011) Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet 377:1085–1095
    Article PubMed Central Google Scholar
  29. Ross R, Bradshaw AJ (2009) The future of obesity reduction: beyond weight loss. Nat Rev Endocrinol 5:319–326
    Article PubMed Google Scholar
  30. Iacobellis G, Singh N, Wharton S, Sharma AM (2008) Substantial changes in epicardial fat thickness after weight loss in severely obese subjects. Obesity 16:1693–1697
    Article PubMed Google Scholar
  31. Kim MK, Tomita T, Kim MJ, Sasai H, Maeda S, Tanaka K (2009) Aerobic exercise training reduces epicardial fat in obese men. J Appl Physiol 106:5–11
    Article PubMed Google Scholar
  32. Bazzocchi A, Filonzi G, Ponti F, Amadori M, Sassi C, Salizzoni E, Albisinni U, Battista G (2013) The role of ultrasonography in the evaluation of abdominal fat: analysis of technical and methodological issues. Acad Radiol 20:1278–1285
    Article PubMed Google Scholar
  33. Iacobellis G, Corradi D, Sharma AM (2005) Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med 2:536–543
    Article PubMed Google Scholar
  34. Lorber D (2013) GLP-1 receptor agonists: effects on cardiovascular risk reduction. Cardiovasc Ther 31:238–249
    Article CAS PubMed Google Scholar
  35. Bacchi E, Negri C, Tarperi C, Baraldo A, Faccioli N, Milanese C, Zanolin ME, Lanza M, Cevese A, Bonora E, Schena F, Moghetti P (2014) Relationships between cardiorespiratory fitness, metabolic control, and fat distribution in type 2 diabetes subjects. Acta Diabetol 51:369–375
    Article CAS PubMed Google Scholar

Download references