l-Proline is a sedative regulator of acute stress in the brain of neonatal chicks (original) (raw)

Abstract

The purpose of the present study was to clarify the central nervous system function of amino acids during acute stress. In Experiment 1, changes in free amino acid pattern were investigated in the brain of neonatal chicks exposed to either restraint with isolation-induced or fasting stress. l-Proline and l-arginine were decreased in the telencephalon and diencephalon under any stress. Since the central nervous system functions of l-arginine during the stress response has recently been reported, in Experiment 2, the effect of intracerebroventricular injection of l-proline (0.5, 1.0, 2.0 μmol) during isolation-induced stress was investigated. l-Proline induced sedative and hypnotic effects in a dose-dependent manner. It is suggested that l-proline may have an important role to attenuate the stress response in the central nervous system of chicks.

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Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science (No. 18208023) and the SKYLARK Food Science Institute. The authors are grateful to the staffs and students of Laboratory of Chemistry and Technology of Animal Products in Kyushu University for their assistance in analysis of amino acids.

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Authors and Affiliations

1. Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, 812-8581, Japan
   K. Hamasu, T. Haraguchi, Y. Kabuki, N. Adachi, S. Tomonaga & M. Furuse
2. Ajinomoto Co., Inc, Kawasaki-ku, Kawasaki, 210-8681, Japan
   H. Sato
3. Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061-0306, USA
   D. M. Denbow

Authors

1. K. Hamasu
2. T. Haraguchi
3. Y. Kabuki
4. N. Adachi
5. S. Tomonaga
6. H. Sato
7. D. M. Denbow
8. M. Furuse

Corresponding author

Correspondence toM. Furuse.

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Hamasu, K., Haraguchi, T., Kabuki, Y. et al. l-Proline is a sedative regulator of acute stress in the brain of neonatal chicks.Amino Acids 37, 377–382 (2009). https://doi.org/10.1007/s00726-008-0164-0

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• Received: 15 May 2008
• Accepted: 28 July 2008
• Published: 12 August 2008
• Issue date: July 2009
• DOI: https://doi.org/10.1007/s00726-008-0164-0

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