Metabolic isoenzyme shifts in cancer as potential novel therapeutic targets (original) (raw)

• Ureta T (1978) The role of isozymes in metabolism: a model of metabolic pathways as the basis for the biological role of isozymes. Curr Top Cell Regul 13:233–258
  Article CAS PubMed Google Scholar
• Cairns RA, Harris I, McCracken S, Mak TW (2011) Cancer cell metabolism. Cold Spring Harb Symp Quant Biol 76:299–311
  Article CAS PubMed Google Scholar
• Hu J, Locasale JW, Bielas JH, O’Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D (2013) Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nat Biotechnol 31:522–529
  Article CAS PubMed Central PubMed Google Scholar
• Warburg O (1924) On the metabolism of cancer cells. Naturwissenschaften 12:1131–1137
  Article CAS Google Scholar
• Teicher BA, Linehan WM, Helman LJ (2012) Targeting cancer metabolism. Clin Cancer Res 18:5537–5545
  Article CAS PubMed Central PubMed Google Scholar
• Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L et al (2012) Passenger deletions generate therapeutic vulnerabilities in cancer. Nature 488:337–342
  Article CAS PubMed Central PubMed Google Scholar
• Pereira da Silva AP, El-Bacha T, Kyaw N, dos Santos RS, da-Silva WS, Almeida FC, Da Poian AT, Galina A (2009) Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. Biochem J 417:717–726
  Article CAS PubMed Google Scholar
• Yamaguchi R, Perkins G (2012) Challenges in targeting cancer metabolism for cancer therapy. EMBO Rep 13:1034–1035
  Article CAS PubMed Central PubMed Google Scholar
• Zhao Y, Liu H, Liu Z, Ding Y, Ledoux SP, Wilson GL, Voellmy R, Lin Y, Lin W, Nahta R et al (2011) Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism. Cancer Res 71:4585–4597
  Article CAS PubMed Central PubMed Google Scholar
• Zhou M, Zhao Y, Ding Y, Liu H, Liu Z, Fodstad O, Riker AI, Kamarajugadda S, Lu J, Owen LB et al (2010) Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol. Mol Cancer 9:33
  Article PubMed Central PubMed Google Scholar
• Atsumi T, Chesney J, Metz C, Leng L, Donnelly S, Makita Z, Mitchell R, Bucala R (2002) High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Res 62:5881–5887
  CAS PubMed Google Scholar
• Jang M, Kim SS, Lee J (2013) Cancer cell metabolism: implications for therapeutic targets. Exp Mol Med 45:e45
  Article PubMed Central PubMed Google Scholar
• Mathupala SP, Ko YH, Pedersen PL (2010) The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies. Biochim Biophys Acta 1797:1225–1230
  Article CAS PubMed Central PubMed Google Scholar
• Mathupala SP, Ko YH, Pedersen PL (2006) Hexokinase II: cancer’s double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25:4777–4786
  Article CAS PubMed Central PubMed Google Scholar
• Iqbal MA, Gupta V, Gopinath P, Mazurek S, Bamezai RN (2014) Pyruvate kinase M2 and cancer: an updated assessment. FEBS Lett 588(16):2685–2692
  Article CAS PubMed Google Scholar
• Brawer MK (2005) Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders. Rev Urol 7(Suppl 7):S21–S26
  PubMed Central PubMed Google Scholar
• Zhao Y, Butler EB, Tan M (2013) Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis 4:e532
  Article CAS PubMed Central PubMed Google Scholar
• Sullivan EJ, Kurtoglu M, Brenneman R, Liu H, Lampidis TJ (2013) Targeting cisplatin-resistant human tumor cells with metabolic inhibitors. Cancer Chemother Pharmacol 73(2):417–427
  Article PubMed Google Scholar
• Clem B, Telang S, Clem A, Yalcin A, Meier J, Simmons A, Rasku MA, Arumugam S, Dean WL, Eaton J et al (2008) Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther 7:110–120
  Article CAS PubMed Google Scholar
• Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC (2010) Identification of small molecule inhibitors of pyruvate kinase M2. Biochem Pharmacol 79:1118–1124
  Article CAS PubMed Central PubMed Google Scholar
• Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF (2005) Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat Biotechnol 23:1303–1307
  Article CAS PubMed Google Scholar
• Shi Y, Pinto BM (2014) Human lactate dehydrogenase a inhibitors: a molecular dynamics investigation. PLoS ONE 9:e86365
  Article PubMed Central PubMed Google Scholar
• Vander Heiden MG (2011) Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 10:671–684
  Article PubMed Google Scholar
• Shim H, Dolde C, Lewis BC, Wu CS, Dang G, Jungmann RA, Dalla-Favera R, Dang CV (1997) c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci USA 94:6658–6663
  Article CAS PubMed Central PubMed Google Scholar
• Koukourakis MI, Giatromanolaki A, Sivridis E, Bougioukas G, Didilis V, Gatter KC, Harris AL (2003) Tumour, angiogenesis research G: lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br J Cancer 89:877–885
  Article CAS PubMed Central PubMed Google Scholar
• Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV (2010) Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci USA 107:2037–2042
  Article CAS PubMed Central PubMed Google Scholar
• Hamanaka RB, Chandel NS (2012) Targeting glucose metabolism for cancer therapy. J Exp Med 209:211–215
  Article CAS PubMed Central PubMed Google Scholar
• Wang JB, Erickson JW, Fuji R, Ramachandran S, Gao P, Dinavahi R, Wilson KF, Ambrosio AL, Dias SM, Dang CV, Cerione RA (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18:207–219
  Article CAS PubMed Central PubMed Google Scholar
• Pongratz RL, Kibbey RG, Shulman GI, Cline GW (2007) Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion. J Biol Chem 282:200–207
  Article CAS PubMed Google Scholar
• Bukato G, Kochan Z, Swierczynski J (1995) Different regulatory properties of the cytosolic and mitochondrial forms of malic enzyme isolated from human brain. Int J Biochem Cell Biol 27:1003–1008
  Article CAS PubMed Google Scholar
• Sukhatme VP, Ren J-G (2013) Methods and compositions for malic enzyme 2 (me2) as a target for cancer therapy. Google Patent Application 13/814,614
• Hao HX, Khalimonchuk O, Schraders M, Dephoure N, Bayley JP, Kunst H, Devilee P, Cremers CW, Schiffman JD, Bentz BG et al (2009) SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science 325:1139–1142
  Article CAS PubMed Google Scholar
• Hanahan D (2011) Weinberg RA: hallmarks of cancer: the next generation. Cell 144:646–674
  Article CAS PubMed Google Scholar
• Furuta E, Okuda H, Kobayashi A, Watabe K (2010) Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta 1805:141–152
  CAS PubMed Central PubMed Google Scholar
• Cardaci S, Ciriolo MR (2012) TCA cycle defects and cancer: when metabolism tunes redox state. Int J Cell Biol 2012:161837
  Article PubMed Central PubMed Google Scholar
• Oyedotun KS, Lemire BD (2004) The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. J Biol Chem 279:9424–9431
  Article CAS PubMed Google Scholar
• Baysal BE, Ferrell RE, Willett-Brozick JE, Lawrence EC, Myssiorek D, Bosch A, van der Mey A, Taschner PE, Rubinstein WS, Myers EN et al (2000) Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 287:848–851
  Article CAS PubMed Google Scholar
• Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, Leigh I, Gorman P, Lamlum H, Rahman S et al (2002) Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 30:406–410
  Article CAS PubMed Google Scholar
• de-Freitas-Junior JC, Bastos LG, Freire-Neto CA, Rocher BD, Abdelhay ES, Morgado-Diaz JA (2012) _N_-glycan biosynthesis inhibitors induce in vitro anticancer activity in colorectal cancer cells. J Cell Biochem 113:2957–2966
  Article CAS PubMed Google Scholar
• Munday MR (2002) Regulation of mammalian acetyl-CoA carboxylase. Biochem Soc Trans 30:1059–1064
  Article CAS PubMed Google Scholar
• Yoon S, Lee MY, Park SW, Moon JS, Koh YK, Ahn YH, Park BW, Kim KS (2007) Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J Biol Chem 282:26122–26131
  Article CAS PubMed Google Scholar
• Bandyopadhyay S, Zhan R, Wang Y, Pai SK, Hirota S, Hosobe S, Takano Y, Saito K, Furuta E, Iiizumi M et al (2006) Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. Cancer Res 66:5934–5940
  Article CAS PubMed Google Scholar
• Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, Mason J, Huang P, Sawyer SK, Fuerth B, Faubert B et al (2011) Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 25:1041–1051
  Article CAS PubMed Central PubMed Google Scholar
• Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing EJ, Tsuchihara K, Bungard D, Berger SL, Jones RG et al (2013) Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model. Cell Death Differ 20:659–668
  Article CAS PubMed Central PubMed Google Scholar
• Kennedy EP, Weiss SB (1956) The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem 222:193–214
  CAS PubMed Google Scholar
• Koboldt DC, Fulton RS, McLellan MD, Schmidt H, Kalicki-Veizer J, McMichael JF, Fulton LL, Dooling DJ, Ding L, Mardis ER et al (2012) Comprehensive molecular portraits of human breast tumours. Nature 490:61–70
  Article CAS Google Scholar
• de Molina AR, Rodriguez-Gonzalez A, Gutierrez R, Martinez-Pineiro L, Sanchez J, Bonilla F, Rosell R, Lacal J (2002) Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. Biochem Biophys Res Commun 296:580–583
  Article Google Scholar
• Elledge SJ, Zhou Z, Allen JB (1992) Ribonucleotide reductase: regulation, regulation, regulation. Trends Biochem Sci 17:119–123
  Article CAS PubMed Google Scholar
• Zheng Z, Chen T, Li X, Haura E, Sharma A, Bepler G (2007) DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. N Engl J Med 356:800–808
  Article CAS PubMed Google Scholar
• Zhang M, Wang J, Yao R, Wang L (2013) Small interfering RNA (siRNA)-mediated silencing of the M2 subunit of ribonucleotide reductase: a novel therapeutic strategy in ovarian cancer. Int J Gynecol Cancer 23:659–666
  Article PubMed Google Scholar
• Bernstein LR (1998) Mechanisms of therapeutic activity for gallium. Pharmacol Rev 50:665–682
  CAS PubMed Google Scholar
• Long CW, Levitzki A, Koshland DE Jr (1970) The subunit structure and subunit interactions of cytidine triphosphate synthetase. J Biol Chem 245:80–87
  CAS PubMed Google Scholar
• Schimmel KJ, Gelderblom H, Guchelaar HJ (2007) Cyclopentenyl cytosine (CPEC): an overview of its in vitro and in vivo activity. Curr Cancer Drug Targets 7:504–509
  Article CAS PubMed Google Scholar
• Politi PM, Xie F, Dahut W, Ford H Jr, Kelley JA, Bastian A, Setser A, Allegra CJ, Chen AP, Hamilton JM et al (1995) Phase I clinical trial of continuous infusion cyclopentenyl cytosine. Cancer Chemother Pharmacol 36:513–523
  Article CAS PubMed Google Scholar
• Mathupala SP (2011) Metabolic targeting of malignant tumors: small-molecule inhibitors of bioenergetic flux. Recent Pat Anticancer Drug Discov 6:6–14
  Article CAS PubMed Central PubMed Google Scholar
• Piatkowska-Jakubas B, Krawczyk-Kulis M, Giebel S, Adamczyk-Cioch M, Czyz A, Maranda EL, Paluszewska M, Palynyczko G, Piszcz J, Holowiecki J (2008) Polish Adult Leukemia G: Use of l-asparaginase in acute lymphoblastic leukemia: recommendations of the polish adult leukemia group. Pol Arch Med Wewn 118:664–669
  CAS PubMed Google Scholar
• Ni Y, Schwaneberg U, Sun ZH (2008) Arginine deiminase, a potential anti-tumor drug. Cancer Lett 261:1–11
  Article CAS PubMed Google Scholar
• Kovacevic Z, Morris HP (1972) The role of glutamine in the oxidative metabolism of malignant cells. Cancer Res 32:326–333
  CAS PubMed Google Scholar
• Shukla K, Ferraris DV, Thomas AG, Stathis M, Duvall B, Delahanty G, Alt J, Rais R, Rojas C, Gao P et al (2012) Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J Med Chem 55:10551–10563
  Article CAS PubMed Central PubMed Google Scholar
• Murata K, Miyoshi E, Kameyama M, Ishikawa O, Kabuto T, Sasaki Y, Hiratsuka M, Ohigashi H, Ishiguro S, Ito S et al (2000) Expression of _N-_acetylglucosaminyltransferase V in colorectal cancer correlates with metastasis and poor prognosis. Clin Cancer Res 6:1772–1777
  CAS PubMed Google Scholar
• Zhang Z, Sun J, Hao L, Liu C, Ma H, Jia L (2013) Modification of glycosylation mediates the invasive properties of murine hepatocarcinoma cell lines to lymph nodes. PLoS ONE 8:e65218
  Article CAS PubMed Central PubMed Google Scholar
• Mendelsohn RD, Helmerhorst EJ, Cipollo JF, Kukuruzinska MA (2005) A hypomorphic allele of the first _N_-glycosylation gene, ALG7, causes mitochondrial defects in yeast. Biochim Biophys Acta 1723:33–44
  Article CAS PubMed Google Scholar
• Rose DR (2012) Structure, mechanism and inhibition of Golgi alpha-mannosidase II. Curr Opin Struct Biol 22:558–562
  Article CAS PubMed Google Scholar
• Elbein AD, Szumilo T, Sanford BA, Sharpless KB, Adams C (1987) Effect of isomers of swainsonine on glycosidase activity and glycoprotein processing. Biochemistry 26:2502–2510
  Article CAS PubMed Google Scholar
• Mahoney WC, Duksin D (1980) Separation of tunicamycin homologues by reversed-phase high-performance liquid chromatography. J Chromatogr 198:506–510
  Article CAS PubMed Google Scholar
• Goss PE, Reid CL, Bailey D, Dennis JW (1997) Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies. Clin Cancer Res 3:1077–1086
  CAS PubMed Google Scholar
• Zastre JA, Sweet RL, Hanberry BS, Ye S (2013) Linking vitamin B1 with cancer cell metabolism. Cancer Metab 1:16
  Article PubMed Central PubMed Google Scholar
• Zastre JA, Hanberry BS, Sweet RL, McGinnis AC, Venuti KR, Bartlett MG, Govindarajan R (2013) Up-regulation of vitamin B1 homeostasis genes in breast cancer. J Nutr Biochem 24:1616–1624
  Article CAS PubMed Google Scholar
• Thomas AA, De Meese J, Le Huerou Y, Boyd SA, Romoff TT, Gonzales SS, Gunawardana I, Kaplan T, Sullivan F, Condroski K et al (2008) Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett 18:509–512
  Article CAS PubMed Google Scholar
• Fawcett WP, Aracava Y, Adler M, Pereira EF, Albuquerque EX (2009) Acute toxicity of organophosphorus compounds in guinea pigs is sex- and age-dependent and cannot be solely accounted for by acetylcholinesterase inhibition. J Pharmacol Exp Ther 328:516–524
  Article CAS PubMed Central PubMed Google Scholar
• Dallner G, Brismar K, Chojnacki T, Swiezewska E (2003) Regulation of coenzyme Q biosynthesis and breakdown. BioFactors 18:11–22
  Article CAS PubMed Google Scholar
• Dallner G, Sindelar PJ (2000) Regulation of ubiquinone metabolism. Free Radic Biol Med 29:285–294
  Article CAS PubMed Google Scholar
• Thurnher M, Gruenbacher G, Nussbaumer O (2013) Regulation of mevalonate metabolism in cancer and immune cells. Biochim Biophys Acta 1831:1009–1015
  Article CAS PubMed Google Scholar
• Casey PJ, Seabra MC (1996) Protein prenyltransferases. J Biol Chem 271:5289–5292
  Article CAS PubMed Google Scholar
• Doll RJ, Kirschmeier P, Bishop WR (2004) Farnesyltransferase inhibitors as anticancer agents: critical crossroads. Curr Opin Drug Discov Dev 7:478–486
  CAS Google Scholar
• Li T, Guo M, Gradishar WJ, Sparano JA, Perez EA, Wang M, Sledg GW (2012) A phase II trial of capecitabine in combination with the farnesyltransferase inhibitor tipifarnib in patients with anthracycline-treated and taxane-resistant metastatic breast cancer: an eastern cooperative oncology group study (E1103). Breast Cancer Res Treat 134:345–352
  Article CAS PubMed Google Scholar
• Rowell CA, Kowalczyk JJ, Lewis MD, Garcia AM (1997) Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo. J Biol Chem 272:14093–14097
  Article CAS PubMed Google Scholar
• Peterson YK, Kelly P, Weinbaum CA, Casey PJ (2006) A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity. J Biol Chem 281:12445–12450
  Article CAS PubMed Google Scholar
• Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC (2010) Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc Natl Acad Sci USA 107:6246–6251
  Article CAS PubMed Central PubMed Google Scholar
• Khosla C, Gokhale RS, Jacobsen JR, Cane DE (1999) Tolerance and specificity of polyketide synthases. Annu Rev Biochem 68:219–253
  Article CAS PubMed Google Scholar
• Koehn FE, Carter GT (2005) The evolving role of natural products in drug discovery. Nat Rev Drug Discov 4:206–220
  Article CAS PubMed Google Scholar
• Dickschat JS (2011) Biosynthesis and function of secondary metabolites. Beilstein J Org Chem 7:1620–1621
  Article CAS PubMed Central PubMed Google Scholar
• Harvey AL (2008) Natural products in drug discovery. Drug Discov Today 13:894–901
  Article CAS PubMed Google Scholar
• Herbert RB (2003) The biosynthesis of plant alkaloids and nitrogenous microbial metabolites. Nat Prod Rep 20:494–508
  Article CAS PubMed Google Scholar
• Guengerich FP (2008) Cytochrome p450 and chemical toxicology. Chem Res Toxicol 21:70–83
  Article CAS PubMed Google Scholar
• Guengerich FP, Wu ZL, Bartleson CJ (2005) Function of human cytochrome P450s: characterization of the orphans. Biochem Biophys Res Commun 338:465–469
  Article CAS PubMed Google Scholar
• Guengerich FP (1999) Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 39:1–17
  Article CAS PubMed Google Scholar