Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice (original) (raw)

References

1. Shan K, Lincoff AM, Young JB: Anthracycline-induced cardiotoxicity. Ann Intern Med 125: 47–58, 1996
   CAS PubMed Google Scholar
2. Hortobagyi GN: Anthracyclines in the treatment of cancer. An overview. Drugs 54: 1–7, 1997
   CAS Google Scholar
3. Singal PK, Li T, Kumar D, Danelisen I, Iliskovic N: Adriamycin-induced heart failure: Mechanism and modulation. Mol Cell Biochem 207: 77–86, 2000
   Article CAS PubMed Google Scholar
4. Sparano JA: Doxorubicin/taxane combinations: Cardiac toxicity and pharmacokinetics. Semin Oncol 26: 14–19, 1999
   CAS Google Scholar
5. Sawyer DB, Fukazawa R, Arstall MA, Kelly RA: Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. Circ Res 84: 257–265, 1999
   CAS PubMed Google Scholar
6. Kumar D, Kirshenbaum LA, Li T, Danelisen I, Singal PK: Apoptosis in adriamycin cardiomyopathy and its modulation by probucol. Antioxid Redox Signal 3: 135–145, 2001
   Article CAS PubMed Google Scholar
7. Long X, Boluyt MO, Hipolito ML, Lundberg MS, Zheng JS, O’Neill L, Cirielli C, Lakatta EG, Crow MT: p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes. J Clin Invest 99: 2635–2643, 1997
   CAS PubMed Google Scholar
8. Leri A, Liu Y, Malhotra A, Li Q, Stiegler P, Claudio PP, Giordano A, Kajstura J, Hintze TH, Anversa P: Pacing-induced heart failure in dogs enhances the expression of p53 and p53-dependent genes in ventricular myocytes. Circulation 97: 194–203, 1998
   CAS PubMed Google Scholar
9. Leri A, Claudio PP, Li Q, Wang X, Reiss K, Wang S, Malhotra A, Kajstura J, Anversa P: Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J Clin Invest 101: 1326–1342, 1998
   Google Scholar
10. Lorenzo E, Ruiz-Ruiz C, Quesada AJ, Hernandez G, Rodriguez A, Lopez-Rivas A, Redondo JM: Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. J Biol Chem 277: 10883–10892, 2002
    Article CAS PubMed Google Scholar
11. Liem AA, Appleyard MV, O’Neill MA, Hupp TR, Chamberlain MP, Thompson AM: Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast cancer cell lines. Br J Cancer 88: 1281–1284, 2003
    Article CAS PubMed Google Scholar
12. Liu X, Chua CC, Gao J, Chen Z, Landy CL, Hamdy R, Chua BH: Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice. Am J Physiol Heart Circ Physiol 286: H933–H939, 2004
    Article CAS PubMed Google Scholar
13. Komarova EA, Gudkov AV: Suppression of p53: A new approach to overcome side effects of antitumor therapy. Biochemistry (Mosc) 65: 41–48, 2000
    CAS Google Scholar
14. Bialik S, Geenen DL, Sasson IE, Cheng R, Horner JW, Evans SM, Lord EM, Koch CJ, Kitsis RN: Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest 100: 1363–1372, 1997
    CAS PubMed Google Scholar
15. Kown MH, Murata S, Jahncke CL, Mari C, Berry GJ, Lijkwan MA, Blankenberg FG, Strauss HW, Robbins RC: Donor cardiac allografts from p53 knockout mice exhibit apoptosis-independent prolongation of survival. Transpl Proc 34: 3274–3276, 2002
    Article CAS Google Scholar
16. Cerutti JM, Delcelo R, Amadei MJ, Nakabashi C, Maciel RM, Peterson B, Shoemaker J, Riggins GJ: A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression. J Clin Invest 113: 1234–1242, 2004
    Article CAS PubMed Google Scholar
17. Gardin JM, Siri FM, Kitsis RN, Edwards JG, Leinwand LA: Echocardiographic assessment of left ventricular mass and systolic function in mice. Circ Res 76: 907–914, 1995
    CAS PubMed Google Scholar
18. Hoit BD, Khoury SF, Kranias EG, Ball N, Walsh RA: In vivo echocardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency. Circ Res 77: 632–637, 1995
    CAS PubMed Google Scholar
19. Pollick C, Hale SL, Kloner RA: Echocardiographic and cardiac Doppler assessment of mice. J Am Soc Echocardiogr 8: 602–610, 1995
    CAS PubMed Google Scholar
20. Shizukuda Y, Buttrick PM, Geenen DL, Borczuk AC, Kitsis RN, Sonnenblick EH: β-adrenergic stimulation causes cardiocyte apoptosis: Influence of tachycardia and hypertrophy. Am J Physiol 275: H961–H968, 1998
    CAS PubMed Google Scholar
21. Shizukuda Y, Helisch A, Yokota R, Ware JA: Downregulation of protein kinase Cδ acivity enhances endothelial cell adaptation to hypoxia. Circulation 100: 1909–1916, 1999
    CAS PubMed Google Scholar
22. Yoda Y, Nakazawa M, Abe T, Kawakami Z: Prevention of doxorubicin myocardial toxicity in mice by reduced glutathione. Cancer Res 46: 2551–2556, 1986
    CAS PubMed Google Scholar
23. Li T, Singal PK: Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol. Circulation 102: 2105–2110, 2000
    CAS PubMed Google Scholar
24. Meng Z: Oxidative damage of sulfur dioxide on various organs of mice: Sulfur dioxide is a systemic oxidative damage agent. Inhal Toxicol 15: 181–195, 2003
    Article CAS PubMed Google Scholar
25. Cao Z, Li Y: The chemical inducibility of mouse cardiac antioxidants and phase 2 enzymes in vivo. Biochem Biophys Res Commun 317: 1080–1088, 2004
    Article CAS PubMed Google Scholar
26. Johnson M, Dimitrov D, Vojta PJ, Barrett JC, Noda A, Pereira-Smith OM, Smith JR: Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/WAF1/p21 RNA in human cells. Mol Carcinog 11: 59–64, 1994
    CAS PubMed Google Scholar
27. Hwang PM, Bunz F, Yu J, Rago C, Chan TA, Murphy MP, Kelso GF, Smith RA, Kinzler KW, Vogelstein B: Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med 7: 1111–1117, 2001
    Article CAS PubMed Google Scholar
28. Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B, Williams J: Cell-cycle arrest versus cell death in cancer therapy. Nat Med 3: 1034–1036, 1997
    Article CAS PubMed Google Scholar
29. Tokino T, Thiagalingam S, el-Deiry WS, Waldman T, Kinzler KW, Vogelstein B: p53 tagged sites from human genomic DNA. Hum Mol Genet 3: 1537–1542, 1994
    CAS PubMed Google Scholar
30. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B: A model for p53-induced apoptosis. Nature 389: 300–305, 1997
    Article CAS PubMed Google Scholar
31. Haupt Y, Maya R, Kazaz A, Oren M: Mdm2 promotes the rapid degradation of p53. Nature 387: 296–299, 1997
    Article CAS PubMed Google Scholar
32. Kubbutat MH, Jones SN, Vousden KH: Regulation of p53 stability by Mdm2. Nature 387: 299–303, 1997
    Article CAS PubMed Google Scholar
33. Vogelstein B, Lane D, Levine AJ: Surfing the p53 network. Nature 408: 307–310, 2000
    Article CAS PubMed Google Scholar
34. Pierzchalski P, Reiss K, Cheng W, Cirielli C, Kajstura J, Nitahara JA, Rizk M, Capogrossi MC, Anversa P: p53 induces myocyte apoptosis via the activation of the renin-angiotensin system. Exp Cell Res 234: 57–65, 1997
    Article CAS PubMed Google Scholar
35. Leri A, Liu Y, Claudio PP, Kajstura J, Wang X, Wang S, Kang P, Malhotra A, Anversa P: Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis. Am J Pathol 154: 567–580, 1999
    CAS PubMed Google Scholar
36. Kotamraju S, Konorev EA, Joseph J, Kalyanaraman B: Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. J Biol Chem 275: 33585–33592, 2000
    Article CAS PubMed Google Scholar
37. Mostafa MG, Mima T, Ohnishi ST, Mori K: S-allylcysteine ameliorates doxorubicin toxicity in the heart and liver in mice. Plant Med 66: 148–151, 2000
    Article CAS Google Scholar
38. Breitbart E, Lomnitski L, Nyska A, Malik Z, Bergman M, Sofer Y, Haseman JK, Grossman S: Effects of water-soluble antioxidant from spinach, NAO, on doxorubicin-induced heart injury. Hum Exp Toxicol 20: 337–345, 2001
    Article CAS PubMed Google Scholar
39. Lipshultz SE, Rifai N, Dalton VM, Levy DE, Silverman LB, Lipsitz SR, Colan SD, Asselin BL, Barr RD, Clavell LA, Hurwitz CA, Moghrabi A, Samson Y, Schorin MA, Gelber RD, Sallan SE: The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med 351: 145–153, 2004
    Article CAS PubMed Google Scholar
40. Johnson TM, Yu ZX, Ferrans VJ, Lowenstein RA, Finkel T: Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc Natl Acad Sci USA 93: 11848–11852, 1996
    Article CAS PubMed Google Scholar
41. Li PF, Dietz R, von Harsdorf R: p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. Embo J 18: 6027–6036, 1999
    Article CAS PubMed Google Scholar
42. el-Missiry MA, Othman AI, Amer MA, Abd el-Aziz MA: Attenuation of the acute adriamycin-induced cardiac and hepatic oxidative toxicity by N-(2-mercaptopropionyl) glycine in rats. Free Radic Res 35: 575–581, 2001
    CAS PubMed Google Scholar
43. Mukherjee S, Banerjee SK, Maulik M, Dinda AK, Talwar KK, Maulik SK: Protection against acute adriamycin-induced cardiotoxicity by garlic: Role of endogenous antioxidants and inhibition of TNF-alpha expression. BMC Pharmacol 3: 16–24, 2003
    Article PubMed Google Scholar

Download references