Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice (original) (raw)
Alcalay RN, Giladi E, Pick CG, Gozes I (2004) Intranasal administration of NAP, a neuroprotective peptide, decreases anxiety-like behavior in aging mice in the elevated plus maze. Neurosci Lett 361:128–131 ArticlePubMedCAS Google Scholar
Arundine M, Aarts M, Lau A, Tymianski M (2004) Vulnerability of central neurons to secondary insults after in vitro mechanical stretch. J Neurosci 24:8106–8123 ArticlePubMedCAS Google Scholar
Arundine M, Tymianski M (2004) Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci 61:657–668 ArticlePubMedCAS Google Scholar
Banks WA, During MJ, Niehoff ML (2004) Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration. J Pharmacol Exp Ther 309:469–475 Google Scholar
Baratz R, Rubovitch V, Frenk H, Pick CG (2010a) The influence of alcohol on behavioral recovery after mTBI in mice. J Neurotrauma 27:555–563 ArticlePubMed Google Scholar
Baratz R, Tweedie D, Rubovitch V, Luo W, Yoon JS, Hoffer BJ, Greig NH, Pick CG (2010b) Tumor necrosis factor-α synthesis inhibitor, 3,6′-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice. J Neurochem 118:1032–1042 Article Google Scholar
Barnett AH (2012) The role of GLP-1 mimetics and basal insulin analogues in type 2 diabetes mellitus: guidance from studies of liraglutide. Diabetes Obes Metab 14:304–314 ArticlePubMedCAS Google Scholar
Bauer R, Fritz H (2004) Pathophysiology of traumatic injury in the developing brain: an introduction and short update. Exp Toxicol Pathol 56:65–73 Google Scholar
Belzung C, Griebel G (2001) Measuring normal and pathological anxiety-like behaviour in mice: a review. Behav Brain Res 125:141–149 ArticlePubMedCAS Google Scholar
Berrigan L, Marshall S, McCullagh S, Velikonja D, Bayley M (2011) Quality of clinical practice guidelines for persons who have sustained mild traumatic brain injury. Brain Inj 25:742–751 ArticlePubMed Google Scholar
Bertilsson G, Patrone C, Zachrisson O, Andersson A, Dannaeus K, Heidrich J, Kortesmaa J, Mercer A, Nielsen E, Rönnholm H, Wikström L (2008) Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson’s disease. J Neurosci Res 86:326–338 ArticlePubMedCAS Google Scholar
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG (2012) An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease-associated Aβ oligomers. J Clin Invest 122:1339–1353 ArticlePubMedCAS Google Scholar
Bramlett HM, Green E, Dietrich WD (1997) Hippocampally dependent and independent chronic spatial navigational deficits following parasagittal fluid percussion brain injury in the rat. Brain Res 762:195–202 ArticlePubMedCAS Google Scholar
Calara F, Taylor K, Han J, Zabala E, Carr EM, Wintle M, Fineman M (2005) A randomized, open-label, crossover study examining the effect of injection site on bioavailability of exenatide (synthetic Exendin-4). Clin Ther 27:210–215 ArticlePubMedCAS Google Scholar
Chaudhuri A, Ghanim H, Vora M, Sia CL, Korzeniewski K, Dhindsa S, Makdissi A, Dandona P (2012) Exenatide exerts a potent antiinflammatory effect. J Clin Endocrinol Metab 97:198–207 ArticlePubMedCAS Google Scholar
Dix SL, Aggleton JP (1999) Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition. Behav Brain Res 99:191–200 ArticlePubMedCAS Google Scholar
Dixon C, Kochanek P, Yan H, Schiding J, Griffith R, Baum E, Marion D, DeKosky ST (1999) One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats. J Neurotrauma 16:109–122 ArticlePubMedCAS Google Scholar
Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang D, Porter L, and for the DURATION-1 Study Group (2008) Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 372:1240–1250 ArticlePubMedCAS Google Scholar
During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, Bland RJ, Klugmann M, Banks WA, Drucker DJ, Haile CN (2003) Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 9:1173–1179 ArticlePubMedCAS Google Scholar
Erreger K, Davis AR, Poe AM, Greig NH, Stanwood GD, Galli A (2012) Exendin-4 decreases amphetamine-induced locomotor activity. Physiol Behav 106:574–578 ArticlePubMedCAS Google Scholar
Faden AI, Demediuk P, Panter SS, Vink R (1989) The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244:798–800 ArticlePubMedCAS Google Scholar
Faul M, Xu L, Wald MM, Coronado VG (2010) Traumatic brain injury in the United States: emergency department visits, hospitalizations and deaths 2002–2006. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, Atlanta Google Scholar
Fleminger S, Oliver D, Lovestone S, Rabe-Hesketh S, Giora A (2003) Head injury as a risk factor for Alzheimer’s disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 74:857–862 ArticlePubMedCAS Google Scholar
Foda MA, Marmarou A (1994) A new model of diffuse brain injury in rats. Part II: morphological characterization. J Neurosurg 80:301–313 ArticlePubMedCAS Google Scholar
Frankola KA, Greig NH, Luo W, Tweedie D (2011) Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases. CNS Neurol Disord Drug Targets 10:391–403 ArticlePubMedCAS Google Scholar
Gallwitz B (2011) Glucagon-like peptide-1 analogues for type 2 diabetes mellitus: current and emerging agents. Drugs 71:1675–1688 ArticlePubMedCAS Google Scholar
Garber AJ (2011) Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability. Diabetes Care 34(Suppl 2):S279–S284 ArticlePubMedCAS Google Scholar
Garner J, Brett SJ (2007) Mechanisms of injury by explosive devices. Anesthesiol Clin 25:147–160 ArticlePubMed Google Scholar
Grant P, Lipscomb D, Quin J (2011) Psychological and quality of life changes in patients using GLP-1 analogues. J Diabetes Complications 25:244–246 ArticlePubMed Google Scholar
Hamilton A, Hölscher C (2009) Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. Neuroreport 20:1161–1166 ArticlePubMedCAS Google Scholar
Harkavyi A, Abuirmeileh A, Lever R, Kingsbury A, Biggs C et al (2008) Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson’s disease. J Neuroinflammation 5:19 ArticlePubMed Google Scholar
Hellewell SC, Yan E, Bye N, Agyapomaa D, Morganti-Kossmann C (2010) Post traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses. J Neurotrauma 27:1997–2010 ArticlePubMed Google Scholar
Hesdorffer DC, Rauch SL, Tamminga CA (2009) Long-term psychiatric outcomes following traumatic brain injury: a review of the literature. J Head Trauma Rehabil 24:452–459 ArticlePubMed Google Scholar
Hinzman JM, Thomas TC, Burmeister JJ, Quintero JE, Huettl P, Pomerleau F, Gerhardt GA, Lifshitz J (2010) Diffuse brain injury elevates tonic glutamate levels and potassium-evoked glutamate release in discrete brain regions at two days post-injury: an enzyme-based microelectrode array study. J Neurotrauma 27:889–899 ArticlePubMed Google Scholar
Hinzman JM, Thomas TC, Quintero JE, Gerhardt GA, Lifshitz J (2012) Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury. J Neurotrauma 29:1197–1208 ArticlePubMed Google Scholar
Hoare SR (2005) Mechanisms of peptide and nonpeptide ligand binding to class B G-protein-coupled receptors. Drug Discov Today 10:417–427 ArticlePubMedCAS Google Scholar
Holscher C (2010) Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer’s disease. Recent Pat CNS Drug Discov 5:109–117 ArticlePubMedCAS Google Scholar
Hossmann KA (1994) Glutamate-mediated injury in focal cerebral ischemia: the excitotoxin hypothesis revised. Brain Pathol 4:23–36 ArticlePubMedCAS Google Scholar
Howard PK, Shapiro SE (2011) Diagnosing and treating mild traumatic brain injury in children. Adv Emerg Nurs J 33:274–278 PubMed Google Scholar
Hunter K, Holscher C (2012) Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci 13:33 ArticlePubMedCAS Google Scholar
Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC (2007) The impact of traumatic brain injuries: a global perspective. NeuroRehabilitation 22:341–353 PubMed Google Scholar
Ikonomovic M, Uryu K, Abrahamson E, Ciallella J, Trojanowski J, Lee V, Clark R, Marion D, Wisniewski S, DeKosky S (2004) Alzheimer’s pathology in human temporal cortex surgically excised after severe brain injury. Exp Neurol 190:192–203 ArticlePubMedCAS Google Scholar
Kastin AJ, Akerstrom V, Pan W (2002) Interactions of glucagon-like peptide-1 (GLP-1) with the blood–brain barrier. J Mol Neurosci 18:7–14 ArticlePubMedCAS Google Scholar
Kastin AJ, Akerstrom V (2003) Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Relat Metab Disord 27:313–318 ArticlePubMedCAS Google Scholar
Lafon-Cazal M, Pietri S, Culcasi M et al (1993) NMDA-dependent superoxide production and neurotoxicity. Nature 364:535–537 ArticlePubMedCAS Google Scholar
Lau A, Tymianski M (2010) Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch 460:525–542 ArticlePubMedCAS Google Scholar
Laurer HL, Lezlinger PM, Mclintoch TK (2000) Models of traumatic brain injury. Eur J Trauma 26:95–100 Article Google Scholar
Levin HS (1998) Cognitive function outcomes after traumatic brain injury. Curr Opin Neurol 11:643–646 ArticlePubMedCAS Google Scholar
Li Y, Chigurupati S, Holloway HW, Mughal M, Tweedie D, Bruestle DA, Mattson MP, Wang Y, Harvey BK, Ray B, Lahiri DK, Greig NH (2012) Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis. PLoS One 7(2):e32008 Google Scholar
Li Y, Duffy KB, Ottinger MA, Ray B, Bailey JA, Holloway HW, Tweedie D, Perry T, Mattson MP, Kapogiannis D, Sambamurti K, Lahiri DK, Greig NH (2010a) GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer’s disease. J Alzheimers Dis 19:1205–1219 PubMed Google Scholar
Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, Powers K, Shen H, Egan JM, Sambamurti K, Brossi A, Lahiri DK, Mattson MP, Hoffer BJ, Wang Y, Greig NH (2009) GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A 106:1285–1290 ArticlePubMedCAS Google Scholar
Li Y, Tweedie D, Mattson MP, Holloway HW, Greig NH (2010b) Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells. J Neurochem 113:1621–1631 PubMedCAS Google Scholar
Lovshin JA, Drucker DJ (2009) Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 5:262–269 ArticlePubMedCAS Google Scholar
Lyeth BG, Jenkins L, Hamm J, Dixon C, Phillips L, Clifton G, Young H, Hayes R (1990) Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain Res 526:249–258 ArticlePubMedCAS Google Scholar
McIntosh TK, Juhler M, Wieloch T (1998) Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998. J Neurotrauma 15:731–769 ArticlePubMedCAS Google Scholar
Magnoni S, Brody DL (2010) New perspectives on amyloid-β dynamics after acute brain injury. Arch Neurol 67:1068–1073 ArticlePubMed Google Scholar
Marklund N, Hillered L (2011) Animal modeling of traumatic brain injury in preclinical drug development: where do we go from here? Br J Pharmacol 164:1207–1229 ArticlePubMedCAS Google Scholar
Marmarou A, Foda MA, van den Brink W, Campbell J, Kita H, Demetriadou K (1994) A new model of diffuse brain injury in rats. Part I: pathophysiology and biomechanics. J Neurosurg 80:291–300 ArticlePubMedCAS Google Scholar
Marshall S, Bayley M, McCullagh S, Velikonja D, Berrigan L (2012) Clinical practice guidelines for mild traumatic brain injury and persistent symptoms. Can Fam Physician 58:257–267 PubMed Google Scholar
Maas AI, Steyerberg EW, Butcher I, Dammers R, Lu J, Marmarou A, Mushkudiani NA, McHugh GS, Murray GD (2007) Prognostic value of computerized tomography scan characteristics in traumatic brain injury: results from the IMPACT study. J Neurotrauma 24:303–314 ArticlePubMed Google Scholar
Maas AI, Stocchetti N, Bullock R (2008) Moderate and severe traumatic brain injury in adults. Lancet Neurol 7:728–741 ArticlePubMed Google Scholar
Messier C (1997) Object recognition in mice: improvement of memory by glucose. Neurobiol Learn Mem 67:172–175 ArticlePubMedCAS Google Scholar
Milman A, Rosenberg A, Weizman R, Pick CG (2005) Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice. J Neurotrauma 22:1003–1010 ArticlePubMedCAS Google Scholar
Moppett IK (2007) Traumatic brain injury: assessment, resuscitation and early management. Br J Anaesth 99:18–31 ArticlePubMedCAS Google Scholar
Oddy M, Humphrey M (1980) Social recovery during the year following severe head injury. J Neurol Neurosurg Psychiatry 43:798–802 ArticlePubMedCAS Google Scholar
Oddy M, Humphrey M, Uttley D (1978) Subjective impairment and social recovery after closed head injury. J Neurol Neurosurg Psychiatry 41:611–616 ArticlePubMedCAS Google Scholar
Oddy M, Coughlan T, Tyerman A, Jenkins D (1985) Social adjustment after closed head injury: a further follow-up seven years after injury. J Neurol Neurosurg Psychiatry 48:564–568 ArticlePubMedCAS Google Scholar
Pawaskar M, Li Q, Reynolds MW (2012) Metabolic outcomes of elderly patient populations initiating exenatide BID versus insulin glargine in an ambulatory care setting. Curr Med Res Opin 28:991–997 ArticlePubMedCAS Google Scholar
Perry T, Greig NH (2003) The glucagon-like peptides: a double-edged therapeutic sword? Trends Pharmacol Sci 24:377–383 ArticlePubMedCAS Google Scholar
Perry T, Haughey NJ, Mattson MP, Egan JM, Greig NH (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther 302:881–888 ArticlePubMedCAS Google Scholar
Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH (2003) Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res 72:603–612 ArticlePubMedCAS Google Scholar
Porter D, Faivre E, Flatt PR, Hölscher C, Gault VA (2012) Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice. Peptides 35:1–8 ArticlePubMedCAS Google Scholar
Raghupathi R, Graham DI, McIntosh TK (2000) Apoptosis after traumatic brain injury. J Neurotrauma 17:927–938 ArticlePubMedCAS Google Scholar
Reynolds IJ, Hastings TG (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J Neurosci 15:3318–27 Google Scholar
Salcedo I, Tweedie D, Li Y, Greig NH (2012) Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders. Br J Pharmacol 166:1586–1599 Google Scholar
Sambamurti K, Greig NH, Lahiri DK (2002) Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer’s disease. Neuromolecular Med 1:1–31 ArticlePubMedCAS Google Scholar
Schultz BA, Cifu DX, McNamee S, Nichols M, Carne W (2011) Assessment and treatment of common persistent sequelae following blast induced mild traumatic brain injury. NeuroRehabilitation 28:309–320 PubMed Google Scholar
Sharma S, Rakoczy S, Brown-Borg H (2010) Assessment of spatial memory in mice. Life Sci 87:521–536 ArticlePubMedCAS Google Scholar
Shohami E, Beit-Yannai E, Horowitz M, Kohen R (1997) Oxidative stress in closed-head injury: brain antioxidant capacity as an indicator of functional outcome. J Cereb Blood Flow Metab 17:1007–1019 ArticlePubMedCAS Google Scholar
Siesjo BK, Zhao Q, Pahlmark K, Siesjo P, Katsura K, Fol-bergrova J (1995) Glutamate, calcium and free radicals as mediators of ischemic brain damage. Ann Thorac Surg 59:1316–1320 ArticlePubMedCAS Google Scholar
Sivanandam TM, Thakur MK (2012) Traumatic brain injury: a risk factor for Alzheimer’s disease. Neurosci Biobehav Rev 36:1376–1381 ArticlePubMed Google Scholar
Strawn JR, D’Alessio DA, Keck PE, Seeley RJ Jr (2008) Failure of glucagon-like peptide-1 to induce panic attacks or anxiety in patients with panic disorder. J Psychiatr Res 42:787–789 ArticlePubMedCAS Google Scholar
Susman M, DiRusso SM, Sullivan T, Risucci D, Nealon P, Cuff S, Haider A, Benzil D (2002) Traumatic brain injury in the elderly: increased mortality and worse functional outcome at discharge despite lower injury severity. J Trauma 53:219–223 ArticlePubMed Google Scholar
Tagliaferri F, Compagnone C, Korsic M, Servadei F, Kraus J (2006) Systematic review of brain injury epidemiology in Europe. Acta Neurochir (Wien) 148:255–268 ArticleCAS Google Scholar
Tashlykov V, Katz Y, Volkov A, Gazit V, Schreiber S, Zohar O, Pick CG (2009) Minimal traumatic brain injury induce apoptotic cell death in mice. J Mol Neurosci 37:16–24 ArticlePubMedCAS Google Scholar
Tweedie D, Milman A, Holloway HW, Li Y, Harvey BK, Shen H, Pistell PJ, Lahiri DK, Hoffer BJ, Wang Y, Pick CG, Greig NH (2007) Apoptotic and behavioral sequelae of mild brain trauma in mice. J Neurosci Res 85:805–815 ArticlePubMedCAS Google Scholar
Uryu K, Chen X, Martinez D, Browne K, Johnson V, Graham D, Lee VM, Trojanowski JQ, Smith DH (2007) Multiple proteins implicated in neurodegenerative disease accumulate in axons after brain trauma in humans. Exp Neurol 208:185–192 ArticlePubMedCAS Google Scholar
Zhang L, Rzigalinski BA, Ellis EF, Satin LS (1996) Reduction of voltage-dependent Mg2+ blockade of NMDA current in mechanically injured neurons. Science 274:1921–1923 ArticlePubMedCAS Google Scholar
Zipp F, Aktas O (2006) The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci 29:518–527 ArticlePubMedCAS Google Scholar
Zitnay GA (2005) Lessons from national and international TBI societies and funds like NBIRTT. Acta Neurochir Suppl 93:131–133 ArticlePubMedCAS Google Scholar
Zohar O, Rubovitch V, Milman A, Schreiber S, Pick CG (2011) Behavioral consequences of minimal traumatic brain injury in mice. Acta Neurobiol Exp (Wars) 71:36–45 Google Scholar