Glucagon-like peptide-1 receptor is involved in learning and neuroprotection (original) (raw)

References

  1. Tseng, C.C., Zhang, X.Y. & Wolfe, M.M. Effect of GIP and GLP-1 antagonists on insulin release in the rat. Am. J. Physiol. 76, E1049–E1054 (1999).
    Google Scholar
  2. Drucker, D.J. The glucagon-like peptides. Endocrinology 142, 521–527 (2001).
    Article CAS Google Scholar
  3. Stoffers, D.A. et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49, 741–748 (2000).
    Article CAS Google Scholar
  4. Turton, M.D. et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379, 69–72 (1996).
    Article CAS Google Scholar
  5. Jin, S.L.C. et al. Distribution of glucagon like peptide I (GLP-1), glucagon, and glicentin in the rat brain: an immunocytochemical study. J. Comp. Neurol. 271, 519–532 (1988).
    Article CAS Google Scholar
  6. Merchenthaler, I., Lane, M. & Shughrue, P. Distribution of pre-proglucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J. Comp. Neurol. 403, 261–280 (1999).
    Article CAS Google Scholar
  7. Alvarez, E., Roncero, I., Chowen, J.A., Thorens, B. & Blazquenz, E. Expression of the glucagons-like peptide receptor gene in rat brain. J. Neurochem. 66, 920–927 (1996).
    Article CAS Google Scholar
  8. Kandel, E.R. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294, 1030–1038 (2001).
    Article CAS Google Scholar
  9. Montrose-Rafizadeh, C. et al. Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells. Endocrinology 140, 1132–1140 (1999).
    Article CAS Google Scholar
  10. Wheeler, M.B. et al. Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C. Endocrinology 133, 57–62 (1993).
    Article CAS Google Scholar
  11. Raufman, J.P., Singh, L. & Eng, J. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9–39) amide, a specific exendin receptor antagonist. J. Biol. Chem. 266, 2897–2902 (1991).
    CAS PubMed Google Scholar
  12. Gallwitz, B. et al. GLP-1-analogues resistant to degradation by dipeptidlyl- peptidase IV in vitro. Regul. Pept. 86, 103–111 (2000).
    Article CAS Google Scholar
  13. Praz, G.A. et al. Regulation of immunoreactive-insulin release from a rat cell line (RINm5F). Biochem. J. 15, 345–352 (1983).
    Article Google Scholar
  14. Weatherly, L.S., Harding, J.W. & Wright, J.W. Effects of discrete kainic acid-induced hippocampal lesions on spatial and contextual learning and memory in rats. Brain Res. 716, 29–38 (1996).
    Article Google Scholar
  15. Morris, R.G.M., Garrud, P., Rawlins, J.N.P. & O'Keefe, J. Place navigation impaired in rats with hippocampal lesions. Nature 297, 681–683 (1982).
    Article CAS Google Scholar
  16. DeWied, D. Long term effect of vasopressin on the maintenance of a conditioned avoidance response in rats. Nature 232, 58–60 (1971).
    Article CAS Google Scholar
  17. Born, J. et al. Sniffing neuropeptides: a transnasal approach to the human brain. Nat. Neurosci. 5, 514–516 (2002).
    Article CAS Google Scholar
  18. Banks, W.A., Kastin, A.J. & Pan, W. Uptake and degradation of blood-borne insulin by the olfactory bulb. Peptides 20, 373–378 (1999).
    Article CAS Google Scholar
  19. Cashion, M.F. & Banks, W.A., Bost, K.L., Kastin, A.J. Transmission routes of HIV-1 gp120 from brain to lymphoid tissues. Brain Res. 822, 26–33 (1999).
    Article CAS Google Scholar
  20. Banks,W.A., Goulet, M., Rushe, J.R., Niehoff, M.L. & Boismenu, R. Differential transport of a secretin analog across the blood-brain and blood-cerebrospinal fluid barriers of the mouse. J. Pharmacol. Exp. Therap. 302, 1062–1069 (2002).
    Article CAS Google Scholar
  21. Setlow, B. & McGaugh, J.L. D2 dopamine receptor blockade immediately post-training enhances retention in hidden and visible platform versions of the water maze. Learn. Mem. 7, 187–191 (2000).
    Article CAS Google Scholar
  22. Santucci, A.C., Schroeder, H. & Riccio, D.C. Homeostatic disruption and memory: effect of insulin administration in rats. Behav. Neurol. Biol. 53, 321–333 (1990).
    Article CAS Google Scholar
  23. Scrocchi, L.A. et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagons-like peptide 1 receptor gene. Nat. Med. 2, 1254–1258 (1996).
    Article CAS Google Scholar
  24. Young, D., Lawlor, P.A., Leone, P., Dragunow, M. & During, M.J. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat. Med. 5, 448–453 (1999).
    Article CAS Google Scholar
  25. Gozes, I. Neuroprotective peptide drug delivery and development: potential new therapeutics. Trends Neurosci. 24, 700–705 (2001).
    Article CAS Google Scholar
  26. Perry, T. et al. A novel neurotrophic property of glucagon-like pepide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J. Pharmacol. Exp. Ther. 300, 958–966 (2002).
    Article CAS Google Scholar
  27. Perry, T., Haughey, N.J., Mattson, M.P., Egan, J.M. & Greig, N.H. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J. Pharmacol. Exp. Ther. 302, 881–888 (2002).
    Article CAS Google Scholar
  28. Schmued, L.C. & Hopkins, K.J. Fluoro-jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 874, 123–130 (2000).
    Article CAS Google Scholar
  29. Buteau, J., Roduit, R., Susini, S. & Prentki, M. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 42, 856–864 (1999).
    Article CAS Google Scholar
  30. Holz, G.G., Leech, C.A. & Habener, J.F. Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1. J. Biol. Chem. 270, 17749–17757 (1995).
    Article CAS Google Scholar
  31. Zhou, J., Wang, X., Pineyro, M.A. & Egan, J.M. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 48, 2358–2366 (1999).
    Article CAS Google Scholar
  32. Perfetti, R., Zhou, J., Doyle, M.E. & Egan, J.M. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141, 4600–4605 (2000).
    Article CAS Google Scholar
  33. Weeber, E.J. & Sweatt, J.D. Molecular neurobiology of human cognition. Neuron 33, 845–848 (2002).
    Article CAS Google Scholar
  34. Ramanathan, M. & Jaiswal, A.K., Bhattacharya, S.K. Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats. Psychopharmacology (Berl.) 135, 361–367 (1998).
    Article CAS Google Scholar
  35. Kastin, A.J., Ackerstrom, V. & Pan, W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J. Mol. Neurosci. 18, 7–14 (2002).
    Article CAS Google Scholar
  36. Kern, W., Born, J., Schreiber, H. & Fehm, H.L. Central nervous system effects of intranasally administered insulin during euglycemia in men. Diabetes 48, 557–563 (1999).
    Article CAS Google Scholar
  37. Chowen, J.A. et al. Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain. Neuropeptides 33, 212–215 (1999).
    Article CAS Google Scholar
  38. Patterson, S.L. et al. Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase. Neuron 32, 123–130 (2001).
    Article CAS Google Scholar
  39. Venable, N. & Kelly, P.H. Effects of NMDA receptor antagonists on passive avoidance learning and retrieval in rats and mice. Psychopharmacology 100, 215–221 (1990).
    Article CAS Google Scholar
  40. Racine, R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32, 281–294 (1972).
    Article CAS Google Scholar

Download references