Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer (original) (raw)

Abstract

Worldwide, rates of esophageal cancer have been keeping highly in recent decades. Genetic variants in multiple cellular pathways might play an important role in altering risk of esophageal carcinoma. In this study, long noncoding RNAs (lncRNAs) functional single nucleotide polymorphisms (SNPs) were investigated in Chinese Han populations. We have genotyped the ANRIL rs2151280 T/C, POLR2E rs3787016 C/T, and HULC rs7763881 A/C SNPs in 380 esophageal squamous cell carcinoma (ESCC) cases and 380 cancer-free controls. POLR2E rs3787016 C/T was associated with a significantly decreased risk for ESCC (CT vs. CC: OR 0.62, 95 % CI 0.44–0.87, P = 0.005; adjusted OR 0.62, 95 % CI 0.44–0.87, P = 0.005). The other SNP, HULC rs7763881, also showed a suggestive association (AC vs. AA: OR 0.70, 95 % CI 0.50–0.98, P = 0.037; adjusted OR 0.69, 95 % CI 0.49–0.97, P = 0.031). ANRIL rs2151280 T/C SNP was not associated with risk of ESCC. In the future, larger studies with other ethnic populations, tissue-specific biological characterization, and detailed individual information should be undertaken to validate current findings.

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Abbreviations

lncRNAs:

Long noncoding RNAs

LD:

Linkage disequilibrium

OR:

Odds ratio

CI:

Confidential interval

SNPs:

Single nucleotide polymorphisms

ESCC:

Esophageal squamous cell carcinoma

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Acknowledgments

We appreciate all patients who participated in this study. This study was supported in part by the National Natural Science Foundation of China (81472332, 81370001, 81300037, 81101889, 81000028, 81341006), Jiangsu Province Natural Science Foundation (BK2010333, BK2011481), Fujian Province Natural Science Foundation (2013J01126, 2013J05116), Fujian Medical University professor fund (JS12008) and Fujian Province science and technology programmed fund (2012Y0030), Social Development Foundation of Zhenjiang (SH2010017), and Changzhou Young Talents and Science-Technology Foundation of Health Bureau (QN201102).

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Authors and Affiliations

  1. Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 350001, Fujian Province, China
    Mingqiang Kang
  2. Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215002, Jiangsu, China
    Yonghua Sang
  3. Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212002, China
    Haiyong Gu, Chao Liu, Yijun Shi, Aizhong Shao, Guowen Ding, Suocheng Chen, Weifeng Tang & Jun Yin
  4. Department of Cardiothoracic Surgery, The First People’s Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University, Changzhou, 213003, China
    Liang Zheng
  5. Cancer Institute, Department of Chemotherapy, People’s Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, 212002, China
    Liming Wang
  6. Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212000, China
    Jun Yin

Authors

  1. Mingqiang Kang
  2. Yonghua Sang
  3. Haiyong Gu
  4. Liang Zheng
  5. Liming Wang
  6. Chao Liu
  7. Yijun Shi
  8. Aizhong Shao
  9. Guowen Ding
  10. Suocheng Chen
  11. Weifeng Tang
  12. Jun Yin

Corresponding authors

Correspondence toMingqiang Kang or Jun Yin.

Additional information

Mingqiang Kang and Yonghua Sang contributed equally to this work.

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Kang, M., Sang, Y., Gu, H. et al. Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer.Tumor Biol. 36, 6401–6408 (2015). https://doi.org/10.1007/s13277-015-3328-z

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