Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279(5349):349–52. ArticleCASPubMed Google Scholar
Brouilette S, Singh RK, Thompson JR, et al. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol. 2003;23(5):842–6. ArticleCASPubMed Google Scholar
Samani NJ, Boultby R, Butler R, et al. Telomere shortening in atherosclerosis. Lancet. 2001;358(9280):472–3. ArticleCASPubMed Google Scholar
Mainous AG 3rd, Codd V, Diaz VA, et al. Leukocyte telomere length and coronary artery calcification. Atherosclerosis. 2010;210(1):262–7. ArticleCASPubMed Google Scholar
Zee RY, Castonguay AJ, Barton NS, et al. Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study. Transl Res. 2010;155(4):166–9. ArticleCASPubMed Google Scholar
Salpea KD, Talmud PJ, Cooper JA, et al. Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. Atherosclerosis. 2010;209(1):42–50. ArticleCASPubMedPubMed Central Google Scholar
Ma H, Zhou Z, Wei S, et al. Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One. 2011;6(6):e20466. ArticleCASPubMedPubMed Central Google Scholar
Epel ES, Blackburn EH, Lin J, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA. 2004;101(49):17312–5. ArticleCASPubMedPubMed Central Google Scholar
Puterman E, Lin J, Krauss J, et al. Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter. Mol Psychiatry. 2014;20(4):529–35. ArticlePubMedPubMed Central Google Scholar
Thompson PD, Buchner D, Pina IL, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation. 2003;107(24):3109–16. ArticlePubMed Google Scholar
Sigal RJ, Kenny GP, Wasserman DH, et al. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006;29(6):1433–8. ArticlePubMed Google Scholar
Lemanne D, Cassileth B, Gubili J. The role of physical activity in cancer prevention, treatment, recovery, and survivorship. Oncology (Williston Park). 2013;27(6):580–5. PubMed Google Scholar
Moyzis RK, Buckingham JM, Cram LS, et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA. 1988;85(18):6622–6. ArticleCASPubMedPubMed Central Google Scholar
Chen W, Kimura M, Kim S, et al. Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule. J Gerontol A Biol Sci Med Sci. 2011;66(3):312–9. ArticleCASPubMed Google Scholar
Verdun RE, Karlseder J. Replication and protection of telomeres. Nature. 2007;447(7147):924–31. ArticleCASPubMed Google Scholar
Oikawa S, Kawanishi S. Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett. 1999;453(3):365–8. ArticleCASPubMed Google Scholar
Kawanishi S, Oikawa S. Mechanism of telomere shortening by oxidative stress. Ann N Y Acad Sci. 2004;1019:278–84. ArticleCASPubMed Google Scholar
von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002;27(7):339–44. Article Google Scholar
Herbig U, Jobling WA, Chen BP, et al. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell. 2004;14(4):501–13. ArticleCASPubMed Google Scholar
de Lange T. How shelterin solves the telomere end-protection problem. Cold Spring Harb Symp Quant Biol. 2010;75:167–77. ArticlePubMed Google Scholar
Chin L, Artandi SE, Shen Q, et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 1999;97(4):527–38. ArticleCASPubMed Google Scholar
Griffith JD, Comeau L, Rosenfield S, et al. Mammalian telomeres end in a large duplex loop. Cell. 1999;97(4):503–14. ArticleCASPubMed Google Scholar
Broccoli D, Smogorzewska A, Chong L, et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet. 1997;17(2):231–5. ArticleCASPubMed Google Scholar
Takai KK, Hooper S, Blackwood S, et al. In vivo stoichiometry of shelterin components. J Biol Chem. 2010;285(2):1457–67. ArticleCASPubMed Google Scholar
van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature. 1997;385(6618):740–3. ArticlePubMed Google Scholar
van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell. 1998;92(3):401–13. ArticlePubMed Google Scholar
Kim SH, Beausejour C, Davalos AR, et al. TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem. 2004;279(42):43799–804. ArticleCASPubMed Google Scholar
Zhang Y, Chen LY, Han X, et al. Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment. Proc Natl Acad Sci USA. 2013;110(14):5457–62. ArticleCASPubMedPubMed Central Google Scholar
Wang F, Podell ER, Zaug AJ, et al. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature. 2007;445(7127):506–10. ArticleCASPubMed Google Scholar
Denchi EL, de Lange T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 2007;448(7157):1068–71. ArticleCASPubMed Google Scholar
Bae NS, Baumann P. A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol Cell. 2007;26(3):323–34. ArticleCASPubMed Google Scholar
Martinez P, Thanasoula M, Carlos AR, et al. Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat Cell Biol. 2010;12(8):768–80. ArticleCASPubMedPubMed Central Google Scholar
Martinez P, Blasco MA. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer. 2011;11(3):161–76. ArticleCASPubMed Google Scholar
Benetti R, Garcia-Cao M, Blasco MA. Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet. 2007;39(2):243–50. ArticleCASPubMed Google Scholar
Blasco MA. The epigenetic regulation of mammalian telomeres. Nat Rev Genet. 2007;8(4):299–309. ArticleCASPubMed Google Scholar
Gonzalo S, Jaco I, Fraga MF, et al. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol. 2006;8(4):416–24. ArticleCASPubMed Google Scholar
Redon S, Reichenbach P, Lingner J. The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res. 2010;38(17):5797–806. ArticleCASPubMedPubMed Central Google Scholar
Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 1985;43(2 Pt 1):405–13. ArticleCASPubMed Google Scholar
Wright WE, Piatyszek MA, Rainey WE, et al. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet. 1996;18(2):173–9. ArticleCASPubMed Google Scholar
Broccoli D, Young JW, de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA. 1995;92(20):9082–6. ArticleCASPubMedPubMed Central Google Scholar
Wernig A, Schafer R, Knauf U, et al. On the regenerative capacity of human skeletal muscle. Artif Organs. 2005;29(3):192–8. ArticlePubMed Google Scholar
Chen CH, Chen RJ. Prevalence of telomerase activity in human cancer. J Formos Med Assoc. 2011;110(5):275–89. ArticleCASPubMed Google Scholar
Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994;266(5193):2011–5. ArticleCASPubMed Google Scholar
Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol. 1998;8(5):279–82. ArticleCASPubMed Google Scholar
Wojtyla A, Gladych M, Rubis B. Human telomerase activity regulation. Mol Biol Rep. 2011;38(5):3339–49. ArticleCASPubMed Google Scholar
Smogorzewska A, de Lange T. Regulation of telomerase by telomeric proteins. Annu Rev Biochem. 2004;73:177–208. ArticleCASPubMed Google Scholar
Wang F, Lei M. Human telomere POT1-TPP1 complex and its role in telomerase activity regulation. Methods Mol Biol. 2011;735:173–87. ArticleCASPubMed Google Scholar
Liu JP, Chen SM, Cong YS, et al. Regulation of telomerase activity by apparently opposing elements. Ageing Res Rev. 2010;9(3):245–56. ArticleCASPubMed Google Scholar
Cesare AJ, Reddel RR. Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet. 2010;11(5):319–30. ArticleCASPubMed Google Scholar
Nabetani A, Ishikawa F. Alternative lengthening of telomeres pathway: recombination-mediated telomere maintenance mechanism in human cells. J Biochem. 2011;149(1):5–14. ArticleCASPubMed Google Scholar
Heaphy CM, Subhawong AP, Hong SM, et al. Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol. 2011;179(4):1608–15. ArticleCASPubMedPubMed Central Google Scholar
Silvestre DC, Pineda JR, Hoffschir F, et al. Alternative lengthening of telomeres in human glioma stem cells. Stem Cells. 2011;29(3):440–51. ArticleCASPubMed Google Scholar
Neumann AA, Watson CM, Noble JR, et al. Alternative lengthening of telomeres in normal mammalian somatic cells. Genes Dev. 2013;27(1):18–23. ArticleCASPubMedPubMed Central Google Scholar
Zijlmans JM, Martens UM, Poon SS, et al. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci USA. 1997;94(14):7423–8. ArticleCASPubMedPubMed Central Google Scholar
Wright WE, Shay JW. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med. 2000;6(8):849–51. ArticleCASPubMed Google Scholar
Vina J, Sanchis-Gomar F, Martinez-Bello V, et al. Exercise acts as a drug; the pharmacological benefits of exercise. Br J Pharmacol. 2012;167(1):1–12. ArticleCASPubMedPubMed Central Google Scholar
Powell KE, Paluch AE, Blair SN. Physical activity for health: what kind? How much? How intense? On top of what? Annu Rev Public Health. 2011;32:349–65. ArticlePubMed Google Scholar
Shalev I, Entringer S, Wadhwa PD, et al. Stress and telomere biology: a lifespan perspective. Psychoneuroendocrinology. 2013;38(9):1835–42. ArticleCASPubMedPubMed Central Google Scholar
Shiels PG, McGlynn LM, MacIntyre A, et al. Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS One. 2011;6(7):e22521. ArticleCASPubMedPubMed Central Google Scholar
Nettleton JA, Diez-Roux A, Jenny NS, et al. Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr. 2008;88(5):1405–12. CASPubMedPubMed Central Google Scholar
Lee M, Martin H, Firpo MA, et al. Inverse association between adiposity and telomere length: the Fels Longitudinal Study. Am J Hum Biol. 2011;23(1):100–6. ArticleCASPubMedPubMed Central Google Scholar
Garcia-Calzon S, Gea A, Razquin C, et al. Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial. Int J Obes (Lond). 2014;38(2):177–82. ArticleCAS Google Scholar
Buxton JL, Das S, Rodriguez A, et al. Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. PLoS One. 2014;9(6):e99133. ArticlePubMedPubMed CentralCAS Google Scholar
Kim S, Parks CG, DeRoo LA, et al. Obesity and weight gain in adulthood and telomere length. Cancer Epidemiol Biomark Prev. 2009;18(3):816–20. ArticleCAS Google Scholar
Valdes AM, Andrew T, Gardner JP, et al. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005;366(9486):662–4. ArticleCASPubMed Google Scholar
Chen S, Yeh F, Lin J, et al. Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study. Aging (Albany NY). 2014;6(5):380–9. ArticlePubMedPubMed Central Google Scholar
Bekaert S, De Meyer T, Rietzschel ER, et al. Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell. 2007;6(5):639–47. ArticleCASPubMed Google Scholar
Diaz VA, Mainous AG, Player MS, et al. Telomere length and adiposity in a racially diverse sample. Int J Obes (Lond). 2010;34(2):261–5. ArticleCAS Google Scholar
Buxton JL, Walters RG, Visvikis-Siest S, et al. Childhood obesity is associated with shorter leukocyte telomere length. J Clin Endocrinol Metab. 2011;96(5):1500–5. ArticleCASPubMedPubMed Central Google Scholar
Al-Attas OS, Al-Daghri N, Bamakhramah A, et al. Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. Acta Paediatr. 2010;99(6):896–9. ArticleCASPubMed Google Scholar
Nordfjall K, Eliasson M, Stegmayr B, et al. Telomere length is associated with obesity parameters but with a gender difference. Obesity (Silver Spring). 2008;16(12):2682–9. ArticlePubMedCAS Google Scholar
Garcia-Calzon S, Moleres A, Marcos A, et al. Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study. PLoS One. 2014;9(2):e89828. ArticlePubMedPubMed CentralCAS Google Scholar
Shen Q, Zhao X, Yu L, et al. Association of leukocyte telomere length with type 2 diabetes in mainland Chinese populations. J Clin Endocrinol Metab. 2012;97(4):1371–4. ArticleCASPubMed Google Scholar
Testa R, Olivieri F, Sirolla C, et al. Leukocyte telomere length is associated with complications of type 2 diabetes mellitus. Diabet Med. 2011;28(11):1388–94. ArticleCASPubMed Google Scholar
Olivieri F, Lorenzi M, Antonicelli R, et al. Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction. Atherosclerosis. 2009;206(2):588–93. ArticleCASPubMed Google Scholar
Sampson MJ, Winterbone MS, Hughes JC, et al. Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes. Diabetes Care. 2006;29(2):283–9. ArticleCASPubMed Google Scholar
Gardner JP, Li S, Srinivasan SR, et al. Rise in insulin resistance is associated with escalated telomere attrition. Circulation. 2005;111(17):2171–7. ArticleCASPubMed Google Scholar
Zhao J, Zhu Y, Lin J, et al. Short leukocyte telomere length predicts risk of diabetes in American Indians: the strong heart family study. Diabetes. 2014;63(1):354–62. ArticleCASPubMed Google Scholar
You NC, Chen BH, Song Y, et al. A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women. Diabetes. 2012;61(11):2998–3004. ArticleCASPubMedPubMed Central Google Scholar
Panayiotou AG, Nicolaides AN, Griffin M, et al. Leukocyte telomere length is associated with measures of subclinical atherosclerosis. Atherosclerosis. 2010;211(1):176–81. ArticleCASPubMed Google Scholar
Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol. 2007;165(1):14–21. ArticlePubMed Google Scholar
Yang Z, Huang X, Jiang H, et al. Short telomeres and prognosis of hypertension in a Chinese population. Hypertension. 2009;53(4):639–45. ArticleCASPubMedPubMed Central Google Scholar
Demissie S, Levy D, Benjamin EJ, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell. 2006;5(4):325–30. ArticleCASPubMed Google Scholar
van der Harst P, van der Steege G, de Boer RA, et al. Telomere length of circulating leukocytes is decreased in patients with chronic heart failure. J Am Coll Cardiol. 2007;49(13):1459–64. ArticlePubMedCAS Google Scholar
Willeit P, Willeit J, Brandstatter A, et al. Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2010;30(8):1649–56. ArticleCASPubMed Google Scholar
Farzaneh-Far R, Cawthon RM, Na B, et al. Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data from the Heart and Soul Study. Arterioscler Thromb Vasc Biol. 2008;28(7):1379–84. ArticleCASPubMedPubMed Central Google Scholar
Brouilette SW, Moore JS, McMahon AD, et al. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet. 2007;369(9556):107–14. ArticleCASPubMed Google Scholar
Haycock PC, Heydon EE, Kaptoge S, et al. Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ. 2014;349:g4227. ArticlePubMedPubMed CentralCAS Google Scholar
Zee RY, Castonguay AJ, Barton NS, et al. Relative leukocyte telomere length and risk of incident ischemic stroke in men: a prospective, nested case-control approach. Rejuvenation Res. 2010;13(4):411–4. ArticleCASPubMedPubMed Central Google Scholar
Perez-Rivera JA, Pabon-Osuna P, Cieza-Borrella C, et al. Effect of telomere length on prognosis in men with acute coronary syndrome. Am J Cardiol. 2014;113(3):418–21. ArticleCASPubMed Google Scholar
Cawthon RM, Smith KR, O’Brien E, et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361(9355):393–5. ArticleCASPubMed Google Scholar
Epel ES, Merkin SS, Cawthon R, et al. The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY). 2009;1(1):81–8. ArticleCAS Google Scholar
Lee HW, Blasco MA, Gottlieb GJ, et al. Essential role of mouse telomerase in highly proliferative organs. Nature. 1998;392(6676):569–74. ArticleCASPubMed Google Scholar
Herrera E, Samper E, Martin-Caballero J, et al. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 1999;18(11):2950–60. ArticleCASPubMedPubMed Central Google Scholar
Rudolph KL, Chang S, Lee HW, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 1999;96(5):701–12. ArticleCASPubMed Google Scholar
Perez-Rivero G, Ruiz-Torres MP, Rivas-Elena JV, et al. Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation. 2006;114(4):309–17. ArticleCASPubMed Google Scholar
Wong KK, Maser RS, Bachoo RM, et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 2003;421(6923):643–8. ArticleCASPubMed Google Scholar
Chang S, Multani AS, Cabrera NG, et al. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet. 2004;36(8):877–82. ArticleCASPubMed Google Scholar
Bhayadia R, Schmidt BM, Melk A, et al. Senescence-induced oxidative stress causes endothelial dysfunction. J Gerontol A Biol Sci Med Sci. 2016;71(2):161–9. ArticlePubMed Google Scholar
Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, et al. Inflammation, oxidative stress, and obesity. Int J Mol Sci. 2011;12(5):3117–32. ArticleCASPubMedPubMed Central Google Scholar
Li H, Horke S, Forstermann U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis. 2014;237(1):208–19. ArticleCASPubMed Google Scholar
Salpea KD, Maubaret CG, Kathagen A, et al. The effect of pro-inflammatory conditioning and/or high glucose on telomere shortening of aging fibroblasts. PLoS One. 2013;8(9):e73756. ArticleCASPubMedPubMed Central Google Scholar
Kurz DJ, Decary S, Hong Y, et al. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci. 2004;117(Pt 11):2417–26. ArticleCASPubMed Google Scholar
Ottaviani A, Gilson E, Magdinier F. Telomeric position effect: from the yeast paradigm to human pathologies? Biochimie. 2008;90(1):93–107. ArticleCASPubMed Google Scholar
Baur JA, Zou Y, Shay JW, et al. Telomere position effect in human cells. Science. 2001;292(5524):2075–7. ArticleCASPubMed Google Scholar
Robin JD, Ludlow AT, Batten K, et al. Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes Dev. 2014;28(22):2464–76. ArticlePubMedPubMed CentralCAS Google Scholar
Koering CE, Pollice A, Zibella MP, et al. Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep. 2002;3(11):1055–61. ArticleCASPubMedPubMed Central Google Scholar
Hernandez-Caballero E, Herrera-Gonzalez NE, Salamanca-Gomez F, et al. Role of telomere length in subtelomeric gene expression and its possible relation to cellular senescence. BMB Rep. 2009;42(11):747–51. ArticleCASPubMed Google Scholar
Ning Y, Xu JF, Li Y, et al. Telomere length and the expression of natural telomeric genes in human fibroblasts. Hum Mol Genet. 2003;12(11):1329–36. ArticleCASPubMed Google Scholar
Codd V, Nelson CP, Albrecht E, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013;45(4):422–7 (7e1–2). ArticleCASPubMedPubMed Central Google Scholar
Masi S, D’Aiuto F, Martin-Ruiz C, et al. Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort. Eur Heart J. 2014;35(46):3296–303. ArticlePubMedPubMed Central Google Scholar
Baragetti A, Palmen J, Garlaschelli K, et al. Telomere shortening over 6 years is associated with increased subclinical carotid vascular damage and worse cardiovascular prognosis in the general population. J Intern Med. 2015;277(4):478–87. ArticleCASPubMed Google Scholar
Cherkas LF, Hunkin JL, Kato BS, et al. The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med. 2008;168(2):154–8. ArticlePubMed Google Scholar
Du M, Prescott J, Kraft P, et al. Physical activity, sedentary behavior, and leukocyte telomere length in women. Am J Epidemiol. 2012;175(5):414–22. ArticlePubMedPubMed Central Google Scholar
Ludlow AT, Zimmerman JB, Witkowski S, et al. Relationship between physical activity level, telomere length, and telomerase activity. Med Sci Sports Exerc. 2008;40(10):1764–71. ArticleCASPubMedPubMed Central Google Scholar
Savela S, Saijonmaa O, Strandberg TE, et al. Physical activity in midlife and telomere length measured in old age. Exp Gerontol. 2013;48(1):81–4. ArticleCASPubMed Google Scholar
Song Z, von Figura G, Liu Y, et al. Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood. Aging Cell. 2010;9(4):607–15. ArticleCASPubMedPubMed Central Google Scholar
Cassidy A, De Vivo I, Liu Y, et al. Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr. 2010;91(5):1273–80. ArticleCASPubMedPubMed Central Google Scholar
Diaz VA, Mainous AG 3rd, Everett CJ, et al. Effect of healthy lifestyle behaviors on the association between leukocyte telomere length and coronary artery calcium. Am J Cardiol. 2010;106(5):659–63. ArticleCASPubMed Google Scholar
Fujishiro K, Diez-Roux AV, Landsbergis PA, et al. Current employment status, occupational category, occupational hazard exposure and job stress in relation to telomere length: the Multiethnic Study of Atherosclerosis (MESA). Occup Environ Med. 2013;70(8):552–60. ArticlePubMedPubMed Central Google Scholar
Kim JH, Ko JH, Lee DC, et al. Habitual physical exercise has beneficial effects on telomere length in postmenopausal women. Menopause. 2012;19(10):1109–15. ArticlePubMed Google Scholar
Garland SN, Johnson B, Palmer C, et al. Physical activity and telomere length in early stage breast cancer survivors. Breast Cancer Res. 2014;16(4):413. ArticlePubMedPubMed Central Google Scholar
Loprinzi PD. Leisure-time screen-based sedentary behavior and leukocyte telomere length: implications for a new leisure-time screen-based sedentary behavior mechanism. Mayo Clin Proc. 2015;90(6):786–90. ArticleCASPubMed Google Scholar
Sjogren P, Fisher R, Kallings L, et al. Stand up for health—avoiding sedentary behaviour might lengthen your telomeres: secondary outcomes from a physical activity RCT in older people. Br J Sports Med. 2014;48(19):1407–9. ArticlePubMed Google Scholar
Washburn RA, Smith KW, Jette AM, et al. The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol. 1993;46(2):153–62. ArticleCASPubMed Google Scholar
Lee JY, Bang HW, Ko JH, et al. Leukocyte telomere length is independently associated with gait speed in elderly women. Maturitas. 2013;75(2):165–9. ArticleCASPubMed Google Scholar
Maeda T, Oyama J, Sasaki M, et al. The physical ability of elderly female Japanese patients with cerebrovascular disease correlates with telomere length in their peripheral blood leukocytes. Aging Clin Exp Res. 2011;23(1):22–8. ArticlePubMed Google Scholar
Maeda T, Oyama J, Higuchi Y, et al. The physical ability of Japanese female elderly with cerebrovascular disease correlates with the telomere length and subtelomeric methylation status in their peripheral blood leukocytes. Gerontology. 2011;57(2):137–43. ArticlePubMed Google Scholar
Bendix L, Gade MM, Staun PW, et al. Leukocyte telomere length and physical ability among Danish twins age 70+. Mech Ageing Dev. 2011;132(11–12):568–72. ArticleCASPubMedPubMed Central Google Scholar
Baylis D, Ntani G, Edwards MH, et al. Inflammation, telomere length, and grip strength: a 10-year longitudinal study. Calcif Tissue Int. 2014;95(1):54–63. ArticleCASPubMedPubMed Central Google Scholar
Soares-Miranda L, Imamura F, Siscovick D, et al. Physical activity, physical fitness, and leukocyte telomere length. Med Sci Sports Exerc. 2015;47(12):2525–34. ArticlePubMedPubMed Central Google Scholar
Zhu H, Wang X, Gutin B, et al. Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with race, sex, adiposity, adipokines, and physical activity. J Pediatr. 2011;158(2):215–20. ArticlePubMed Google Scholar
Garatachea N, Santos-Lozano A, Sanchis-Gomar F, et al. Elite athletes live longer than the general population: a meta-analysis. Mayo Clin Proc. 2014;89(9):1195–200. ArticlePubMed Google Scholar
Werner C, Furster T, Widmann T, et al. Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation. 2009;120(24):2438–47. ArticlePubMed Google Scholar
LaRocca TJ, Seals DR, Pierce GL. Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. Mech Ageing Dev. 2010;131(2):165–7. ArticleCASPubMedPubMed Central Google Scholar
Denham J, Nelson CP, O’Brien BJ, et al. Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors. PLoS One. 2013;8(7):e69377. ArticleCASPubMedPubMed Central Google Scholar
Denham J, O’Brien BJ, Prestes PR, et al. Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres. J Appl Physiol (1985). 2015;120(2):148–58. Article Google Scholar
Mathur S, Ardestani A, Parker B, et al. Telomere length and cardiorespiratory fitness in marathon runners. J Investig Med. 2013;61(3):613–5. ArticlePubMed Google Scholar
Laine MK, Eriksson JG, Kujala UM, et al. Effect of intensive exercise in early adult life on telomere length in later life in men. J Sports Sci Med. 2015;14(2):239–45. PubMedPubMed Central Google Scholar
Mason C, Risques RA, Xiao L, et al. Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women. Obesity (Silver Spring). 2013;21(12):E549–54. ArticlePubMedPubMed Central Google Scholar
Krauss J, Farzaneh-Far R, Puterman E, et al. Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study. PLoS One. 2011;6(11):e26983. ArticleCASPubMedPubMed Central Google Scholar
Osthus IB, Sgura A, Berardinelli F, et al. Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study. PLoS One. 2012;7(12):e52769. ArticlePubMedPubMed CentralCAS Google Scholar
Ponsot E, Lexell J, Kadi F. Skeletal muscle telomere length is not impaired in healthy physically active old women and men. Muscle Nerve. 2008;37(4):467–72. ArticleCASPubMed Google Scholar
Venturelli M, Morgan GR, Donato AJ, et al. Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age. Clin Sci (Lond). 2014;127(6):415–21. ArticleCASPubMedPubMed Central Google Scholar
Collins M, Renault V, Grobler LA, et al. Athletes with exercise-associated fatigue have abnormally short muscle DNA telomeres. Med Sci Sports Exerc. 2003;35(9):1524–8. ArticleCASPubMed Google Scholar
Rae DE, Vignaud A, Butler-Browne GS, et al. Skeletal muscle telomere length in healthy, experienced, endurance runners. Eur J Appl Physiol. 2010;109(2):323–30. ArticlePubMed Google Scholar
Kadi F, Ponsot E, Piehl-Aulin K, et al. The effects of regular strength training on telomere length in human skeletal muscle. Med Sci Sports Exerc. 2008;40(1):82–7. ArticlePubMed Google Scholar
Ornish D, Lin J, Daubenmier J, et al. Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol. 2008;9(11):1048–57. ArticleCASPubMed Google Scholar
Ornish D, Lin J, Chan JM, et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013;14(11):1112–20. ArticleCASPubMed Google Scholar
Melk A, Tegtbur U, Hilfiker-Kleiner D, et al. Improvement of biological age by physical activity. Int J Cardiol. 2014;176(3):1187–9. ArticlePubMed Google Scholar
Puterman E, Lin J, Blackburn E, et al. The power of exercise: buffering the effect of chronic stress on telomere length. PLoS One. 2010;5(5):e10837. ArticlePubMedPubMed CentralCAS Google Scholar
Aviv A. The epidemiology of human telomeres: faults and promises. J Gerontol A Biol Sci Med Sci. 2008;63(9):979–83. ArticlePubMed Google Scholar
Aviv A, Hunt SC, Lin J, et al. Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. Nucleic Acids Res. 2011;39(20):e134. ArticleCASPubMedPubMed Central Google Scholar
Martin-Ruiz CM, Baird D, Roger L, et al. Reproducibility of telomere length assessment: an international collaborative study. Int J Epidemiol. 2015;44(5):1673–83. ArticlePubMed Google Scholar
Bouchard C, Daw EW, Rice T, et al. Familial resemblance for VO2max in the sedentary state: the HERITAGE family study. Med Sci Sports Exerc. 1998;30(2):252–8. ArticleCASPubMed Google Scholar
Bouchard C, An P, Rice T, et al. Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study. J Appl Physiol (1985). 1999;87(3):1003–8. CAS Google Scholar
Dyrstad SM, Hansen BH, Holme IM, et al. Comparison of self-reported versus accelerometer-measured physical activity. Med Sci Sports Exerc. 2014;46(1):99–106. ArticlePubMed Google Scholar
Garriguet D, Colley RC. A comparison of self-reported leisure-time physical activity and measured moderate-to-vigorous physical activity in adolescents and adults. Health Rep. 2014;25(7):3–11. PubMed Google Scholar
Tully MA, Panter J, Ogilvie D. Individual characteristics associated with mismatches between self-reported and accelerometer-measured physical activity. PLoS One. 2014;9(6):e99636. ArticlePubMedPubMed CentralCAS Google Scholar
Ludlow AT, Witkowski S, Marshall MR, et al. Chronic exercise modifies age-related telomere dynamics in a tissue-specific fashion. J Gerontol A Biol Sci Med Sci. 2012;67(9):911–26. ArticlePubMedPubMed CentralCAS Google Scholar
Werner C, Hanhoun M, Widmann T, et al. Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis. J Am Coll Cardiol. 2008;52(6):470–82. ArticleCASPubMed Google Scholar
Wolf SA, Melnik A, Kempermann G. Physical exercise increases adult neurogenesis and telomerase activity, and improves behavioral deficits in a mouse model of schizophrenia. Brain Behav Immun. 2011;25(5):971–80. ArticleCASPubMed Google Scholar
Chilton WL, Marques FZ, West J, et al. Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. PLoS One. 2014;9(4):e92088. ArticlePubMedPubMed Central Google Scholar
Laye MJ, Solomon TP, Karstoft K, et al. Increased shelterin mRNA expression in peripheral blood mononuclear cells and skeletal muscle following an ultra-long-distance running event. J Appl Physiol (1985). 2012;112(5):773–81. ArticleCAS Google Scholar
Ludlow AT, Lima LC, Wang J, et al. Exercise alters mRNA expression of telomere-repeat binding factor 1 in skeletal muscle via p38 MAPK. J Appl Physiol (1985). 2012;113(11):1737–46. ArticleCASPubMed Central Google Scholar
Schuler G, Adams V, Goto Y. Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives. Eur Heart J. 2013;34(24):1790–9. ArticleCASPubMed Google Scholar
Sanz C, Gautier JF, Hanaire H. Physical exercise for the prevention and treatment of type 2 diabetes. Diabetes Metab. 2010;36(5):346–51. ArticleCASPubMed Google Scholar
Slentz CA, Houmard JA, Kraus WE. Modest exercise prevents the progressive disease associated with physical inactivity. Exerc Sport Sci Rev. 2007;35(1):18–23. ArticlePubMed Google Scholar
Oeseburg H, de Boer RA, van Gilst WH, et al. Telomere biology in healthy aging and disease. Pflugers Arch. 2010;459(2):259–68. ArticleCASPubMed Google Scholar
Khansari N, Shakiba Y, Mahmoudi M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov. 2009;3(1):73–80. ArticleCASPubMed Google Scholar
Ludlow AT, Spangenburg EE, Chin ER, et al. Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers. J Gerontol A Biol Sci Med Sci. 2014;69(7):821–30. ArticleCASPubMedPubMed Central Google Scholar
Gleeson M, Bishop NC, Stensel DJ, et al. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011;11(9):607–15. ArticleCASPubMed Google Scholar
Leeuwenburgh C, Heinecke JW. Oxidative stress and antioxidants in exercise. Curr Med Chem. 2001;8(7):829–38. ArticleCASPubMed Google Scholar
Shin YA, Lee JH, Song W, et al. Exercise training improves the antioxidant enzyme activity with no changes of telomere length. Mech Ageing Dev. 2008;129(5):254–60. ArticleCASPubMed Google Scholar
Dinami R, Ercolani C, Petti E, et al. miR-155 drives telomere fragility in human breast cancer by targeting TRF1. Cancer Res. 2014;74(15):4145–56. ArticleCASPubMed Google Scholar
Benetti R, Gonzalo S, Jaco I, et al. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol. 2008;15(9):998. ArticleCASPubMed Google Scholar
Yamada Y, Nishida T, Horibe H, et al. Identification of hypo- and hypermethylated genes related to atherosclerosis by a genome-wide analysis of DNA methylation. Int J Mol Med. 2014;33(5):1355–63. CASPubMed Google Scholar
Ribel-Madsen R, Fraga MF, Jacobsen S, et al. Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. PLoS One. 2012;7(12):e51302. ArticleCASPubMedPubMed Central Google Scholar
Denham J, Marques FZ, O’Brien BJ, et al. Exercise: putting action into our epigenome. Sports Med. 2014;44(2):189–209. ArticlePubMed Google Scholar
Voisin S, Eynon N, Yan X, et al. Exercise training and DNA methylation in humans. Acta Physiol (Oxf). 2015;213(1):39–59. ArticleCASPubMed Google Scholar
McGee SL, Hargreaves M. Histone modifications and exercise adaptations. J Appl Physiol (1985). 2011;110(1):258–63. ArticleCAS Google Scholar
Denham J, O’Brien BJ, Marques FZ, et al. Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise. J Appl Physiol (1985). 2015;118(4):475–88. ArticleCAS Google Scholar
Guilleret I, Benhattar J. Unusual distribution of DNA methylation within the hTERT CpG island in tissues and cell lines. Biochem Biophys Res Commun. 2004;325(3):1037–43. ArticleCASPubMed Google Scholar
Zhu J, Zhao Y, Wang S. Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene. Protein Cell. 2010;1(1):22–32. ArticleCASPubMedPubMed Central Google Scholar
Renaud S, Loukinov D, Bosman FT, et al. CTCF binds the proximal exonic region of hTERT and inhibits its transcription. Nucleic Acids Res. 2005;33(21):6850–60. ArticleCASPubMedPubMed Central Google Scholar
Liu L, Saldanha SN, Pate MS, et al. Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation. Genes Chromosomes Cancer. 2004;41(1):26–37. ArticleCASPubMed Google Scholar
Benetti R, Gonzalo S, Jaco I, et al. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol. 2008;15(3):268–79. ArticleCASPubMedPubMed Central Google Scholar
Borghini A, Giardini G, Tonacci A, et al. Chronic and acute effects of endurance training on telomere length. Mutagenesis. 2015;30(5):711–6. ArticleCASPubMed Google Scholar
Loprinzi PD, Loenneke JP, Blackburn EH. Movement-based behaviors and leukocyte telomere length among US adults. Med Sci Sports Exerc. 2015;47(11):2347–52. ArticleCASPubMed Google Scholar
Weischer M, Bojesen SE, Nordestgaard BG. Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4576 general population individuals with repeat measurements 10 years apart. PLoS Genet. 2014;10(3):e1004191. ArticlePubMedPubMed CentralCAS Google Scholar
Yang JH, Han H, Jang SY, et al. A comparison of the Ghent and revised Ghent nosologies for the diagnosis of Marfan syndrome in an adult Korean population. Am J Med Genet A. 2012;158A(5):989–95. ArticlePubMed Google Scholar
Kingma EM, de Jonge P, van der Harst P, et al. The association between intelligence and telomere length: a longitudinal population based study. PLoS One. 2012;7(11):e49356. ArticleCASPubMedPubMed Central Google Scholar
Mirabello L, Huang WY, Wong JY, et al. The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. Aging Cell. 2009;8(4):405–13. ArticleCASPubMedPubMed Central Google Scholar
Woo J, Tang N, Leung J. No association between physical activity and telomere length in an elderly Chinese population 65 years and older. Arch Intern Med. 2008;168(19):2163–4. ArticlePubMed Google Scholar
Loprinzi PD. Cardiorespiratory capacity and leukocyte telomere length among adults in the United States. Am J Epidemiol. 2015;182(3):198–201. ArticlePubMed Google Scholar
Maynard S, Keijzers G, Hansen AM, et al. Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance. Acta Physiol (Oxf). 2015;213(1):156–70. ArticleCASPubMed Google Scholar
Simpson RJ, Cosgrove C, Chee MM, et al. Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. Exerc Immunol Rev. 2010;16:40–55. PubMed Google Scholar
Bruunsgaard H, Jensen MS, Schjerling P, et al. Exercise induces recruitment of lymphocytes with an activated phenotype and short telomeres in young and elderly humans. Life Sci. 1999;65(24):2623–33. ArticleCASPubMed Google Scholar
Hovatta I, de Mello VD, Kananen L, et al. Leukocyte telomere length in the Finnish Diabetes Prevention Study. PLoS One. 2012;7(4):e34948. ArticleCASPubMedPubMed Central Google Scholar
Botha M, Grace L, Bugarith K, et al. The impact of voluntary exercise on relative telomere length in a rat model of developmental stress. BMC Res Notes. 2012;5:697. ArticlePubMedPubMed Central Google Scholar