Glucose Metabolism and Insulin Receptor Binding and mRNA Levels in Tissues of Dahl Hypertensive Rats* (original) (raw)

Journal Article

,

1

Hypertension Unit, Department of Internal Medicine, University of Udine School of Medicine

,

Udine

,

Italy

2

Division of Endocrinology, University of California San Francisco, San Francisco General Hospital

,

San Francisco, California

USA

.

Address correspondence and reprint requests to Leonardo A. Sechi, MD,

Hypertension Unit, Department of Internal Medicine, University of Udine School of Medicine, Ospedale Civile, Padiglione Medicine

,

33100 Udine

,

Italy

E-mail: sechi@uniud.it

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,

2

Division of Endocrinology, University of California San Francisco, San Francisco General Hospital

,

San Francisco, California

USA

.

Search for other works by this author on:

,

1

Hypertension Unit, Department of Internal Medicine, University of Udine School of Medicine

,

Udine

,

Italy

Search for other works by this author on:

,

1

Hypertension Unit, Department of Internal Medicine, University of Udine School of Medicine

,

Udine

,

Italy

Search for other works by this author on:

,

1

Hypertension Unit, Department of Internal Medicine, University of Udine School of Medicine

,

Udine

,

Italy

Search for other works by this author on:

,

2

Division of Endocrinology, University of California San Francisco, San Francisco General Hospital

,

San Francisco, California

USA

.

Search for other works by this author on:

1

Hypertension Unit, Department of Internal Medicine, University of Udine School of Medicine

,

Udine

,

Italy

Search for other works by this author on:

Published:

01 November 1997

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Leonardo A Sechi, Chandi A Griffin, Laura Zingaro, Cristiana Catena, Stefano De Carli, Morris Schambelan, Ettore Bartoli, Glucose Metabolism and Insulin Receptor Binding and mRNA Levels in Tissues of Dahl Hypertensive Rats, American Journal of Hypertension, Volume 10, Issue 11, November 1997, Pages 1223–1230, https://doi.org/10.1016/S0895-7061(97)00220-3
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Abstract

Increased insulinemic response to an oral glucose load has been demonstrated in Dahl salt-sensitive hypertensive rats. To determine whether this abnormality is mediated at the level of the insulin receptor, we compared insulin receptor binding and mRNA levels in tissues of Dahl salt-sensitive rats (DS) and in their normotensive controls, Dahl salt-resistant rats (DR). To evaluate possible influences of dietary sodium intake, rats were fed either low (0.07% NaCl) or high salt (7.5% NaCl) chow until the DS became hypertensive, and then were killed by decapitation. Fasting plasma glucose and plasma insulin levels did not differ between DR and DS rats and were not affected by salt intake. In response to an oral glucose load, plasma glucose had a similar increase in DR and DS rats, but the increase in plasma insulin was significantly greater in DS rats. Scatchard analysis of binding was obtained from in situ autoradiographic studies performed in frozen skeletal muscle and kidney sections, and insulin receptor mRNA levels were measured by slot-blot hybridization. Number and affinity of insulin receptors were comparable in skeletal muscle and kidney of DR and DS rats and, in both groups, binding parameters were not affected by dietary sodium chloride. Hepatic and renal insulin receptor mRNA levels were also comparable in DR and DS rats fed either low or high salt chow. Thus, increased plasma insulin response to oral glucose load is associated with normal insulin receptor binding and gene expression in peripheral tissues in rats with Dahl hypertension. A postreceptor defect is likely responsible for the decreased sensitivity to insulin in this model of genetic hypertension. Am J Hypertens 1997;10:1223–1230 © 1997 American Journal of Hypertension, Ltd.

© American Journal of Hypertension, Ltd. 1997

Topic:

• hypertension
• glucose metabolism
• glucose
• plasma
• insulin receptor
• rna, messenger
• insulin
• kidney
• rats
• plasma glucose
• affinity

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