Decreased thalamic D2/D3 receptor binding in drug-naive patients with schizophrenia: a PET study with [11C]FLB 457 (original) (raw)

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Department of Clinical Neuroscience, Psychiatry Section, Karolinska Psychiatric Centre, Karolinska Hospital, S-171 76 Stockholm, Sweden

Address for correspondence: Dr M. Talvik, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Psychiatric Centre, Karolinska Hospital, S-171 76 Stockholm, Sweden. Tel.: +45 8 517 723 85_Fax_:

+46 517 717 53

E-mail: mirjam.talvik@nvso.sll.se

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Department of Clinical Neuroscience, Psychiatry Section, Karolinska Psychiatric Centre, Karolinska Hospital, S-171 76 Stockholm, Sweden

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Department of Clinical Neuroscience, Psychiatry Section, Karolinska Psychiatric Centre, Karolinska Hospital, S-171 76 Stockholm, Sweden

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Department of Clinical Neuroscience, Psychiatry Section, Karolinska Psychiatric Centre, Karolinska Hospital, S-171 76 Stockholm, Sweden

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Department of Clinical Neuroscience, Psychiatry Section, Karolinska Psychiatric Centre, Karolinska Hospital, S-171 76 Stockholm, Sweden

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Received:

11 December 2002

Revision received:

15 June 2003

Published:

01 December 2003

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Mirjam Talvik, Anna-Lena Nordström, Hans Olsson, Christer Halldin, Lars Farde, Decreased thalamic D2/D3 receptor binding in drug-naive patients with schizophrenia: a PET study with [11C]FLB 457, International Journal of Neuropsychopharmacology, Volume 6, Issue 4, December 2003, Pages 361–370, https://doi.org/10.1017/S1461145703003699
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Abstract

The thalamus is a neuroanatomic structure that has reciprocal connections with several brain regions suggested to be involved in the pathophysiology of schizophrenia. Recent studies have reported structural as well as functional abnormalities of the thalamus in schizophrenia. The aim of the present exploratory study was to examine D2/D3 dopamine receptors in the thalamus as well as the anterior cingulate and the frontal and temporal cortices by using the high-affinity radioligand [11C]FLB 457 and positron emission tomography (3D PET) and to explore the data in relation to disease, age and psychopathology. Nine drug-naive patients with schizophrenia and eight control subjects were examined. Regional binding potential (BP) values were calculated using the simplified reference tissue model. The D2/D3 receptor binding was significantly lower in the right medial thalamus in the schizophrenia patients compared to control subjects. In addition, we found a significant negative age effect on the D2/D3 BP in the frontal and temporal cortex for both groups. There was no significant age effect on the D2/D3 BP in the thalamus or in the anterior cingulate. The result provides additional support to the view that the age effect on D2/D3 receptors differ between brain regions. The preliminary finding of low thalamic D2/D3 BP in patients strengthens the hypothesis that the thalamus is a key region in the pathophysiology of schizophrenia.

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© 2003 Collegium Internationale Neuropsychopharmacologicum

Topic:

• positron-emission tomography
• diencephalon
• psychopathology
• dopamine receptors
• schizophrenia
• thalamus
• brain
• temporal lobe
• anterior cingulate gyrus
• affinity

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