Conjugated Polymer Nanogel Binding Anticancer Drug through Hydrogen Bonds for Sustainable Drug Delivery (original) (raw)

ArticleNovember 14, 2019

Conjugated Polymer Nanogel Binding Anticancer Drug through Hydrogen Bonds for Sustainable Drug Delivery

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ACS Applied Bio Materials

Cite this: ACS Appl. Bio Mater. 2019, 2, 12

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Published November 14, 2019

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Copyright © 2019 American Chemical Society

Abstract

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Hydrogen-bonded drug conjugation is highly expected as the next-generation smart therapeutic agent that remains stable in biological medium. A carrier design strategy of hydrogen-bonded drug conjugates as pendants in conjugated polymer nanogel is developed. The H-bond acceptor uracil-functionalized poly(_p_-phenylenevinylene) and 2, 6-diamino pyridine (H-bond donor)-functionalized doxorubicin (Dox-Py) are synthesized. Further, chemically cross-linked PPV-nanogel with hydrogen-bonded drug complex (PPV-NG/Dox-Py) is fabricated. The presence of triple-point hydrogen bonding in polymer complex as well as in nanogel network is confirmed by 1H NMR and FT-IR. The hydrophobic microenvironment offered by conjugated polymers backbone stabilizes the hydrogen bonding in the nanogel network. PPV-nanogel/Dox-Py hydrogen-bonded conjugation facilitates higher drug-loading efficiency (82%) and cancer-cell-killing efficiency than encapsulated drug, indicating the superiority of the present design. Sustainable release of Dox-Py is achieved for several days in response to the redox intracellular and acidic environment inside the cancer cells. The proposed hydrogen bond conjugation strategy could provide a broad platform for developing high-value nanotherapeutics.

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Copyright © 2019 American Chemical Society

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ACS Applied Bio Materials

Cite this: ACS Appl. Bio Mater. 2019, 2, 12

Click to copy citationCitation copied!

Published November 14, 2019

Copyright © 2019 American Chemical Society

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