Identification of Glycoproteins in Human Cerebrospinal Fluid with a Complementary Proteomic Approach (original) (raw)

ArticleAugust 30, 2006

Identification of Glycoproteins in Human Cerebrospinal Fluid with a Complementary Proteomic Approach

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Journal of Proteome Research

Cite this: J. Proteome Res. 2006, 5, 10

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Published August 30, 2006

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Copyright © 2006 American Chemical Society

Abstract

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Biomarkers are pressingly needed to assist with the clinical diagnosis of neurodegenerative diseases and/or the monitoring of disease progression. Glycoproteins are enriched in bodily fluids such as human cerebrospinal fluid (CSF), an ideal source for discovering biomarkers due to its proximity to the central nervous system (CNS), and consequently can serve as diagnostic and/or therapeutic markers for CNS diseases. We report here an in-depth identification of glycoproteins in human CSF using a complementary proteomic approach which integrated hydrazide chemistry and lectin affinity column for glycoprotein enrichment, followed by multidimensional chromatography separation and tandem mass spectrometric analysis. Using stringent criteria, a total of 216 glycoproteins, including many low-abundance proteins, was identified with high confidence. Approximately one-third of these proteins was already known to be relevant to the CNS structurally or functionally. This investigation, for the first time, not only categorized many glycoproteins in human CSF but also expanded the existing overall CSF protein database.

Keywords: mass spectrometry • proteomics • cerebrospinal fluid • glycoprotein • hydrazide chemistry • lectin affinity column

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Copyright © 2006 American Chemical Society

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The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.