Analysis of the use of fortified medium in continuous culture of mammalian cells (original) (raw)

• Batt BC, Davis RH and Kompala DS (1990) Inclined sedimentation for selective retention of viable hybridomas in a continuous suspension bioreactor. Biotechnol Prog 6: 458-64.
  Article PubMed CAS Google Scholar
• Bibila TA, Ranucci CS, Konstantin G, Buckland BC and Aunins JG (1994) Monoclonal Antibody Process Development using Medium Concentrates. Biotechnol Prog 10: 87-96.
  PubMed CAS Google Scholar
• Birch JR, Lambert K, Thompson PW, Kenny AC and Wood LA (1987) Antibody Production with Airlift Fermentors. In: Lydersen BK (ed.) Large Scale Cell Culture Technology (1–20) Hanser, New York.
  Google Scholar
• Bree MA, Dhurjati P, Geoghegan RF, Jr. and Robnett B (1988) Kinetic Modelling of Hybridoma Cell Growth and Immunoglobulin Production in a Large-Scale Suspension Culture. Biotechnol Bioeng 32: 1067-1072.
  Article CAS PubMed Google Scholar
• Bushell ME, Bell SL, Scott MF, Spier RE, J.N. W and Sanders PG (1994) Enhancement of Monoclonal Antibody yield by Hybridoma fed-batch culture, resulting in extended maintenance of Viable Cell population. Biotechnol Bioeng 44: 1099-1106.
  Article PubMed CAS Google Scholar
• Comer MJ, Kearns MJ, Wahl J, Munster M, Lorenz T, Szperalski B, Koch S, Behrendt U and Brunner H (1990) Industrial Production of Monoclonal Antibodies and Therapeutic Proteins by Dialysis Fermentation. Cytotechnology 3: 295-299.
  Article PubMed CAS Google Scholar
• de la Broise D, Noiseux M, Lemieux R and Massie B (1991) Long Term Perfusion Culture of Hybridoma: a “Grow or Die” Cell Cycle System. Biotechnol Bioeng 38: 781-787.
  Article CAS PubMed Google Scholar
• Fleischacker R (1986) Practical matters in instrumentation for mammalian cell cultures. In: Thilly WJ (ed.) Mammalian Cell Technology) Butterworth, London.
  Google Scholar
• Fleischaker RJJ and Sinskey A (1981) Oxygen demand and supply in cell culture. Eur J Appl Microbiol Biotechnol 12: 193-197.
  Article Google Scholar
• Fleischaker RT (1982) An experimental study in the use of instrumentation to analyze metabolism and product formation in cell culture. Thesis, Massachusetts Institute of Technology, Cambridge, MA.
  Google Scholar
• Frame K (1988) A Kinetic Study of Hybridoma Growth and Monoclonal Antibody Production in a CSTR. Thesis, University of Minnesota, Minneapolis, MN.
  Google Scholar
• Frame KK and Hu W-S (1991) Kinetic study of hybridoma cell growth in continuous culture. I. A model for non-producing cells. Biotechnol Bioeng 37: 55-64.
  Article PubMed CAS Google Scholar
• Glacken MW (1991) Bioreactor Control and Optimization. In: Ho CS and Wang DIC (ed.) Animal Cell Bioreactors (373-404) Butterworth-Heinemann, Oxford.
  Google Scholar
• Glacken MW, Adema E and Sinskey AJ (1988) Mathematical descriptions of hybridoma culture kinetics: I. Initial metabolic rates. Biotechnol Bioeng 32: 491-506.
  Article CAS PubMed Google Scholar
• Glacken MW, Fleischaker RJ and Sinskey AJ (1986) Reduction of waste product excretion via nutrient control: Possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells. Biotechnol Bioeng 28: 1376-1389.
  Article CAS PubMed Google Scholar
• Hu WS and Oberg MG (1990) Monitoring and control of animal cell bioreactors: biochemical engineering considerations. [Review]. Bioprocess Technology 10: 451-81.
  PubMed CAS Google Scholar
• Hu WS and Piret JM (1992) Mammalian cell culture processes. [Review] [44 refs]. Curr Opin Biotechnol 3: 110-4.
  Article PubMed CAS Google Scholar
• Hu W-S and Peshwa MV (1991) Animal cell bioreactors. Recent advances and challenges to scale-up. Can J Chem Eng 69: 409-420.
  Article CAS Google Scholar
• Hu W-S, Zhou W and Europa LF (1998) Controlling mammalian cell metabolism in bioreactors. Korean J Microbiol Biotechnol 8: 8-13.
  Google Scholar
• Kitano K, Shintani Y, Ichimori Y, Tsukamoto K, Sasai S and Kida M (1986) Production of human monoclonal antibodies by heterohybridomas. Appl Microbiol Biotechnol 24: 282-286.
  Article CAS Google Scholar
• Konstantinov K, Chuppa S, Sajan E, Tsai Y, Yoon S and Golini F (1994) Real-time biomass-concentration monitoring in animal-cell cultures. Trends Biotechnol 12: 324-333.
  Article PubMed CAS Google Scholar
• Konstantinov KB (1996) Monitoring and Control Of the Physiological State Of Cell Cultures. Biotechnol Bioeng 52: 271-289.
  Article CAS PubMed Google Scholar
• Konstantinov KB, Nishio N, Seki T and Yoshida T (1991) Physiologically motivated strategies for control of the fed-batch cultivation of recombinant Escherichia coli for phenylalanine production. J Ferm Bioeng: 350-355.
• Konstantinov KB, Pambayun R, Matanguihan R, Yoshida T, Perusich CM and Hu W-S (1992) On-line monitoring of hybridoma cell growth using a laser turbidity sensor. Biotechnol Bioeng 40: 1337-1342.
  Article CAS PubMed Google Scholar
• Konstantinov KB, Tsai YS, Moles D and Matanguihan R (1996) Control Of Long-Term Perfusion Chinese Hamster Ovary Cell Glucose Auxostat. Biotechnol Prog 12: 100-109.
  Article PubMed CAS Google Scholar
• Kurokawa H, Park YS, Iijima S and Kobayashi T (1994) Growth Characteristics in Fed-Batch Culture of Hybridoma Cells with Control of Glucose and Glutamine Concentrations. Biotechnol Bioeng 44: 95-103.
  Article CAS PubMed Google Scholar
• Kurokawa H, Tatsuya O, Kamihira M, Park YS, Iijima S and Kobayashi T (1993) Kinetic study of Hybridoma Metabolism and Antibody production in Continuous Culture using Serumfree media. J Ferm Bioeng 76: 128-133.
  Article CAS Google Scholar
• Kyung Y-S, Peshwa MV, Gryte DM and W-S. H (1994) High cell density culture of mammalian cells with dynamic perfusion based on on-line oxygen uptake rate measurements. Cytotechnology 14: 183-190.
  Article PubMed CAS Google Scholar
• Laporte TL, Shevitz J, Kim YS and Wag SS (1995) Hybridoma Perfusion system using a sedimentation device. Biotechnol Techniques 9: 837-842.
  Article CAS Google Scholar
• Matanguihan RM, Pambayun R, Izuishi T, Konstantinov KB, Yoshida T, Gryte DM and Hu WS (1993) Development of instrumentation and control strategy in bioreactor culture of hybridoma cells. In: Kaminogawa S et al. (eds) Animal Cell Technology: Basic and Applied Aspects. (501-507.) Kluwer Academic Publishers, Dordrecht.
  Google Scholar
• Merten OW, Palfi GE, Staheli J and Steiner J (1987) Invasive infrared sensor for the determination of the cell number in a continuous fermentation of hybridomas. Dev Biol Standard 66: 357-360.
  CAS Google Scholar
• Miller WM, Wilke CR and Blanch HW (1988) A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH. Biotechnol Bioeng 32: 947-965.
  Article CAS PubMed Google Scholar
• Nicholson ML, Hampson BS, Pugh GG and Ho CS (1991) Continuous cell culture. In: Ho CS and Wang DIC (ed.) Animal Cell Bioreactors (269-303) Butterworth-Heinemann, Oxford.
  Google Scholar
• Oh SKW, Chua FKF and Choo ABH (1995) Intracellular responses of productive hybridomas subjected to high osmotic pressure. Biotechnol Bioeng 46: 525-535.
  Article CAS PubMed Google Scholar
• Oyaas K, Ellingsen TE, Dyrset N and Levine DW (1994) Hyperosmotic hybridoma cell cultures: increased monoclonal antibody production with addition of glycine betaine. Biotechnol Bioeng 44: 991-998.
  Article CAS PubMed Google Scholar
• Ozturk SS and Palsson BO (1991) Effect of Medium Osmolarity on Hybridoma Growth, Metabolism, and Antibody Production. Biotechnol Bioeng 37: 989-993.
  Article CAS PubMed Google Scholar
• Riley MR, M. R, J. ZX, A. AM and W. MD (1997) Simultaneous measurement of glucose and glutamine in insect cell culture media by near infrared spectroscopy. Biotechnol Bioeng 55: 11-15.
  Article CAS PubMed Google Scholar
• Seamans TC and Hu W-S (1990) Kinetics of Growth and Antibody Production by a Hybridoma Cell Line in a Perfusion Culture. J Ferm Bioeng 70: 241-245.
  Article CAS Google Scholar
• Takamatsu H, Hamamoto K, Ishimaru K, Yokoyama S and Tokashiki M (1996) Large-Scale Perfusion Culture Process For Suspended Mammalian That Uses a Centrifuge With Multiple Settling Zones. Appl Microbiol Biotechnol 45: 454-457.
  PubMed CAS Google Scholar
• Takazawa Y and Tokashiki M (1989) High Cell Density Perfusion Culture of Mouse-Human Hybridomas. Appl Microbiol Biotechnol 32: 280-284.
  Article Google Scholar
• Tokashiki M, Arai T, Hamamoto K and Ishimaru K (1990) High density culture of hybridoma cells using a perfusion culture vessel with an external centrifuge. Cytotechnology 3: 239-44.
  Article PubMed CAS Google Scholar
• Vits H and Hu W-S (1992) Fluctuations in Continuous Mammalian Cell Bioreactors with Retention. Biotechnol Prog 8: 397-403.
  Article PubMed CAS Google Scholar
• Wang G, Zhang W, Jacklin C, Eppstein L and Freedman D (1993) High Cell Density Perfusion Culture of Hybridoma Cells for Production of Monoclonal Antibodies in the Celligen Packed Bed Reactor. In: Wang G, Zhang W, Jacklin C, Eppstein L and Freedman D, (ed.) Animal Cell Technology: Basic and Applied Aspects. (463-469) Kluwer Academic Publishers, Dordrecht.
  Google Scholar
• Xie L and Wang DI (1997) Integrated Approaches to the Design of Media and Feeding Strategies for Fed-batch Cultures of Animal Cells. Trends Biotechnol 15: 109-13.
  Article PubMed CAS Google Scholar
• Xie L and Wang DIC (1994) Fed-batch cultivation of animal cells using different medium design concepts and feeding strategies. Biotechnol Bioeng 43: 1175-1189.
  Article CAS PubMed Google Scholar
• Xie LZ and Wang DIC (1996) High Cell Density and High Monoclonal Antibody Production through Medium Design and Rational Control In a Bioreactor. Biotechnol Bioeng 51: 725-729.
  Article CAS PubMed Google Scholar
• Zhang S, Handa-Corrigan A and Spier RE (1993) Kinetics of Cell Metabolism and Antibody Production in High Concentration Perfusion Cultures. In: Zhang S, A. H-C and Spier RE, (ed.) Animal Cell Technology: Basic and Applied Aspects. (309-324.) Kluwer Academic Publishers, Dordrecht.
  Google Scholar
• Zhong J-J, Konstantinov KB and Yoshida T (1994) Computer-aided on-line monitoring of physiological variables in suspended cell cultures of Perilla frutescens in a bioreactor. J Ferm Bioeng 77: 445-447.
  Article CAS Google Scholar
• Zhou W and Hu W-S (1994) On-line characterization of a hybridoma cell culture process. Biotechnol Bioeng 44: 170-177.
  Article CAS PubMed Google Scholar
• Zhou W and Hu W-S (1995) Effect of insulin on a serum-free hybridoma culture. Biotechnol Bioeng 47: 181-185.
  Article CAS PubMed Google Scholar
• Zhou WC, Rehm J and Hu WS (1995) High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding. Biotechnol Bioeng 46: 579-587.
  Article CAS PubMed Google Scholar
• Zhou W-C, Rehm J, Europa A and Hu W-S (1997) Alteration of mammalian cell metabolism by dynamic nutrient feeding. Cytotechnology 24: 99-108.
  Article CAS Google Scholar