Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines (original) (raw)
References
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, TyckoB, Hibshoosh H, Wigler MH, Parsons R: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943–1947, 1997 ArticlePubMed Google Scholar
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV: Identification of a candidate tumour suppressor gene,MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356–362, 1997 ArticlePubMed Google Scholar
Olschwang S, Serova-Sinilnikova OM, Lenoir GM, Thomas G: PTEN germ-line mutations in juvenile polyposis coli. Nat Genet 18: 12–14, 1998 ArticlePubMed Google Scholar
Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C, Parsons R: Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16: 64–67, 1997 ArticlePubMed Google Scholar
Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R, Gorlin RJ, Eng C: Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet 16: 333–334, 1997 ArticlePubMed Google Scholar
Chiariello E, Roz L, Albarosa R, Magnani I, Finocchiaro G: PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. Oncogene 16: 541–545, 1998 ArticlePubMed Google Scholar
Wang SI, Puc J, Li J, Bruce JN, Cairns P, Sidransky D, Parsons R: Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 57: 4183–4186, 1997 PubMed Google Scholar
Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J: Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 57: 3660–3663, 1997 PubMed Google Scholar
Risinger JI, Hayes AK, Berchuck A, Barrett JC: PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 57: 4736–4738, 1997 PubMed Google Scholar
Butler MP, Wang SI, Chaganti RS, Parsons R, Dalla-Favera R: Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas. Genes Chromosomes Cancer 24: 322–327, 1999 ArticlePubMed Google Scholar
Whang YE, Wu X, Suzuki H, Reiter RE, Tran C, Vessella RL, Said JW, Isaacs WB, Sawyers CL: Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci USA 95: 5246–5250, 1998 PubMed Google Scholar
Yokomizo A, Tindall DJ, Drabkin H, Gemmill R, Franklin W, Yang P, Sugio K, Smith DI, Liu W: PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. Oncogene 17: 475–479, 1998 PubMed Google Scholar
McMenamin ME, Soung P, Perera S, Kaplan I, Loda M, Sellers WR: Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 59: 4291–4296, 1999 PubMed Google Scholar
Yaginuma Y, Yamashita T, Ishiya T, Morizaki A, Katoh Y, Takahashi T, Hayashi H, Ishikawa M: Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers. Mol Carcinog 27: 110–116, 2000 ArticlePubMed Google Scholar
Kang YH, Lee HS, Kim WH: Promoter methylation and silencing of PTEN in gastric carcinoma. Lab Invest 82: 285–291, 2002 PubMed Google Scholar
Tang ZY: Hepatocellular carcinoma–cause, treatment and metastasis. World J Gastroenterol 7: 445–454, 2001 PubMed Google Scholar
Wild CP, Hall AJ: Primary prevention of hepatocellular carcinoma in developing countries. Mutat Res 462: 381–393, 2000 ArticlePubMed Google Scholar
Biden K, Young J, Buttenshaw R, Searle J, Cooksley G, Xu DB, Leggett B: Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population. Hepatology 25: 593–597, 1997 ArticlePubMed Google Scholar
Qin G, Su J, Ning Y, Duan X, Luo D, Lotlikar PD: p53 protein expression in patients with hepatocellular carcinoma from the high incidence area of Guangxi, Southern China. Cancer Lett 121: 203–210, 1997 ArticlePubMed Google Scholar
Fujiwara Y, Hoon DS, Yamada T, Umeshita K, Gotoh M, Sakon M, Nishisho I, Monden M: PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas. Jpn J Cancer Res 91: 287–292, 2000 PubMed Google Scholar
Piao Z, Park C, Park JH, Kim H: Allelotype analysis of hepatocellular carcinoma. Int J Cancer 75: 29–33, 1998 ArticlePubMed Google Scholar
Yao YJ, Ping XL, Zhang H, Chen FF, Lee PK, Ahsan H, Chen CJ, Lee PH, PeacockeM, Santella RM, Tsou HC: PTEN/MMAC1 mutations in hepatocellular carcinomas. Oncogene 18: 3181–3185, 1999 ArticlePubMed Google Scholar
Mathew CG, Smith BA, Thorpe K, Wong Z, Royle NJ, Jeffreys AJ, Ponder BA: Deletion of genes on chromosome 1 in endocrine neoplasia. Nature 328: 524–526, 1987 ArticlePubMed Google Scholar
Spinardi L, Mazars R, Theillet C: Protocols for an improved detection of point mutations by SSCP. Nucleic Acids Res 19: 4009, 1991 PubMed Google Scholar
De Nichilo MO, Yamada KM: Integrin alpha v beta 5-dependent serine phosphorylation of paxillin in cultured human macrophages adherent to vitronectin. J Biol Chem 271: 11016–11022, 1996 ArticlePubMed Google Scholar
Sacco R, Leuci D, Tortorella C, Fiore G, Marinosci F, Schiraldi O, Antonaci S: Transforming growth factor beta1 and soluble Fas serum levels in hepatocellular carcinoma. Cytokine 12: 811–814, 2000 ArticlePubMed Google Scholar
Tsai JF, Jeng JE, Chuang LY, Yang ML, HoMS, Chang WY, Hsieh MY, Lin ZY, Tsai JH: Clinical evaluation of urinary transforming growth factor-beta1 and serum alpha-fetoprotein as tumour markers of hepatocellular carcinoma. Br J Cancer 75: 1460–1466, 1997 PubMed Google Scholar
Schlaepfer DD, Hunter T: Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol 8: 151–157, 1998 ArticlePubMed Google Scholar
Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM: PTEN interactions with focal adhesion kinase and suppression of the 33 extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 274: 20693–20703, 1999 ArticlePubMed Google Scholar
Georgescu MM, Kirsch KH, Kaloudis P, Yang H, Pavletich NP, Hanafusa H: Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. Cancer Res 60: 7033–7038, 2000 PubMed Google Scholar
Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP: Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99: 323–334, 1999 PubMed Google Scholar
Yeh KT, Chang JG, Chen YJ, Chen ST, Yu SY, Shih MC, Perng LI, Wang JC, Tsai M, Chang CP: Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma. Cancer Invest 18: 123–129, 2000 PubMed Google Scholar
Cairns P, Okami K, Halachmi S, Halachmi N, Esteller M, Herman JG, Jen J, Isaacs WB, Bova GS, Sidransky D: Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 57: 4997–5000, 1997 PubMed Google Scholar
Ebert MP, Fei G, Schandl L, Mawrin C, Dietzmann K, Herrera P, Friess H, Gress TM, Malfertheiner P: Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1. Br J Cancer 86: 257–262, 2002 ArticlePubMed Google Scholar
Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK: The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci USA 95: 13513–13518, 1998 ArticlePubMed Google Scholar
Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL: The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci USA 95: 15587–15591, 1998 ArticlePubMed Google Scholar
Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM: Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280: 1614–1617, 1998 ArticlePubMed Google Scholar
Cary LA, Han DC, Polte TR, Hanks SK, Guan JL: Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol 140: 211–221, 1998 ArticlePubMed Google Scholar