Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines (original) (raw)

References

  1. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, TyckoB, Hibshoosh H, Wigler MH, Parsons R: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943–1947, 1997
    Article PubMed Google Scholar
  2. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV: Identification of a candidate tumour suppressor gene,MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356–362, 1997
    Article PubMed Google Scholar
  3. Olschwang S, Serova-Sinilnikova OM, Lenoir GM, Thomas G: PTEN germ-line mutations in juvenile polyposis coli. Nat Genet 18: 12–14, 1998
    Article PubMed Google Scholar
  4. Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C, Parsons R: Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16: 64–67, 1997
    Article PubMed Google Scholar
  5. Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R, Gorlin RJ, Eng C: Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet 16: 333–334, 1997
    Article PubMed Google Scholar
  6. Chiariello E, Roz L, Albarosa R, Magnani I, Finocchiaro G: PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. Oncogene 16: 541–545, 1998
    Article PubMed Google Scholar
  7. Wang SI, Puc J, Li J, Bruce JN, Cairns P, Sidransky D, Parsons R: Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 57: 4183–4186, 1997
    PubMed Google Scholar
  8. Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J: Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 57: 3660–3663, 1997
    PubMed Google Scholar
  9. Risinger JI, Hayes AK, Berchuck A, Barrett JC: PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 57: 4736–4738, 1997
    PubMed Google Scholar
  10. Butler MP, Wang SI, Chaganti RS, Parsons R, Dalla-Favera R: Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas. Genes Chromosomes Cancer 24: 322–327, 1999
    Article PubMed Google Scholar
  11. Whang YE, Wu X, Suzuki H, Reiter RE, Tran C, Vessella RL, Said JW, Isaacs WB, Sawyers CL: Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci USA 95: 5246–5250, 1998
    PubMed Google Scholar
  12. Yokomizo A, Tindall DJ, Drabkin H, Gemmill R, Franklin W, Yang P, Sugio K, Smith DI, Liu W: PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. Oncogene 17: 475–479, 1998
    PubMed Google Scholar
  13. McMenamin ME, Soung P, Perera S, Kaplan I, Loda M, Sellers WR: Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 59: 4291–4296, 1999
    PubMed Google Scholar
  14. Yaginuma Y, Yamashita T, Ishiya T, Morizaki A, Katoh Y, Takahashi T, Hayashi H, Ishikawa M: Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers. Mol Carcinog 27: 110–116, 2000
    Article PubMed Google Scholar
  15. Kang YH, Lee HS, Kim WH: Promoter methylation and silencing of PTEN in gastric carcinoma. Lab Invest 82: 285–291, 2002
    PubMed Google Scholar
  16. Tang ZY: Hepatocellular carcinoma–cause, treatment and metastasis. World J Gastroenterol 7: 445–454, 2001
    PubMed Google Scholar
  17. Wild CP, Hall AJ: Primary prevention of hepatocellular carcinoma in developing countries. Mutat Res 462: 381–393, 2000
    Article PubMed Google Scholar
  18. Biden K, Young J, Buttenshaw R, Searle J, Cooksley G, Xu DB, Leggett B: Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population. Hepatology 25: 593–597, 1997
    Article PubMed Google Scholar
  19. Qin G, Su J, Ning Y, Duan X, Luo D, Lotlikar PD: p53 protein expression in patients with hepatocellular carcinoma from the high incidence area of Guangxi, Southern China. Cancer Lett 121: 203–210, 1997
    Article PubMed Google Scholar
  20. Fujiwara Y, Hoon DS, Yamada T, Umeshita K, Gotoh M, Sakon M, Nishisho I, Monden M: PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas. Jpn J Cancer Res 91: 287–292, 2000
    PubMed Google Scholar
  21. Piao Z, Park C, Park JH, Kim H: Allelotype analysis of hepatocellular carcinoma. Int J Cancer 75: 29–33, 1998
    Article PubMed Google Scholar
  22. Yao YJ, Ping XL, Zhang H, Chen FF, Lee PK, Ahsan H, Chen CJ, Lee PH, PeacockeM, Santella RM, Tsou HC: PTEN/MMAC1 mutations in hepatocellular carcinomas. Oncogene 18: 3181–3185, 1999
    Article PubMed Google Scholar
  23. Mathew CG, Smith BA, Thorpe K, Wong Z, Royle NJ, Jeffreys AJ, Ponder BA: Deletion of genes on chromosome 1 in endocrine neoplasia. Nature 328: 524–526, 1987
    Article PubMed Google Scholar
  24. Spinardi L, Mazars R, Theillet C: Protocols for an improved detection of point mutations by SSCP. Nucleic Acids Res 19: 4009, 1991
    PubMed Google Scholar
  25. De Nichilo MO, Yamada KM: Integrin alpha v beta 5-dependent serine phosphorylation of paxillin in cultured human macrophages adherent to vitronectin. J Biol Chem 271: 11016–11022, 1996
    Article PubMed Google Scholar
  26. Sacco R, Leuci D, Tortorella C, Fiore G, Marinosci F, Schiraldi O, Antonaci S: Transforming growth factor beta1 and soluble Fas serum levels in hepatocellular carcinoma. Cytokine 12: 811–814, 2000
    Article PubMed Google Scholar
  27. Tsai JF, Jeng JE, Chuang LY, Yang ML, HoMS, Chang WY, Hsieh MY, Lin ZY, Tsai JH: Clinical evaluation of urinary transforming growth factor-beta1 and serum alpha-fetoprotein as tumour markers of hepatocellular carcinoma. Br J Cancer 75: 1460–1466, 1997
    PubMed Google Scholar
  28. Giancotti FG, Ruoslahti E: Integrin signaling. Science 285: 1028–1032, 1999
    Article PubMed Google Scholar
  29. Schlaepfer DD, Hunter T: Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol 8: 151–157, 1998
    Article PubMed Google Scholar
  30. Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM: PTEN interactions with focal adhesion kinase and suppression of the 33 extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 274: 20693–20703, 1999
    Article PubMed Google Scholar
  31. Georgescu MM, Kirsch KH, Kaloudis P, Yang H, Pavletich NP, Hanafusa H: Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. Cancer Res 60: 7033–7038, 2000
    PubMed Google Scholar
  32. Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP: Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99: 323–334, 1999
    PubMed Google Scholar
  33. Yeh KT, Chang JG, Chen YJ, Chen ST, Yu SY, Shih MC, Perng LI, Wang JC, Tsai M, Chang CP: Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma. Cancer Invest 18: 123–129, 2000
    PubMed Google Scholar
  34. Cairns P, Okami K, Halachmi S, Halachmi N, Esteller M, Herman JG, Jen J, Isaacs WB, Bova GS, Sidransky D: Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 57: 4997–5000, 1997
    PubMed Google Scholar
  35. Ebert MP, Fei G, Schandl L, Mawrin C, Dietzmann K, Herrera P, Friess H, Gress TM, Malfertheiner P: Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1. Br J Cancer 86: 257–262, 2002
    Article PubMed Google Scholar
  36. Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK: The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci USA 95: 13513–13518, 1998
    Article PubMed Google Scholar
  37. Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL: The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci USA 95: 15587–15591, 1998
    Article PubMed Google Scholar
  38. Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM: Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280: 1614–1617, 1998
    Article PubMed Google Scholar
  39. Cary LA, Han DC, Polte TR, Hanks SK, Guan JL: Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol 140: 211–221, 1998
    Article PubMed Google Scholar

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