Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers (original) (raw)

References

  1. Louis, D.N. & Gusella, J.F. A tiger behind many doors: multiple genetic pathways to malignant glioma. Trends. Genet. 11, 412–415 (1995).
    Article CAS Google Scholar
  2. Fults, D., Redone, C.A., Thomas, G.A. & White, R. Allelotype of human malignant astrocytoma. Cancer Res. 50, 5784–5789 (1990).
    PubMed CAS Google Scholar
  3. Rahseed, B.K., Fuller, G.N., Friedman, A.M., Signer, D.D. & Signer, S.H. Loss of heterozygosity for 10q loci in human gliomas. Genes Chromosome Cancer 5, 75–82 (1992).
    Article Google Scholar
  4. Herbst, R.A., Weiss, J., Ehnis, A., Cavenee, W.K. & Arden, K.C. Loss of heterozygosity for 10q22-qter in malignant melanoma progression. Cancer Res. 54, 3111–3114 (1994).
    PubMed CAS Google Scholar
  5. Rempel, S.A., Schwechheimer, K., Davis, R.L., Cavenee, W.K. & Rosenblum, M.L. Loss of heterozygosity for loci on chromosome 10 is associated with morphologically malignant meningioma progression. Cancer Res. 53, 2386–2392 (1993).
    PubMed CAS Google Scholar
  6. Morita, R. et al. Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma. Cancer Res. 51, 5817–5820 (1991).
    PubMed CAS Google Scholar
  7. Eagle, L.R. et al. Mutation of the MX11 gene in prostate cancer. Nature Genet. 9, 249–255 (1995).
    Article CAS Google Scholar
  8. Peterson, I. et al. Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q, and 17p. Brit. J. Cancer 75, 79–86 (1997).
    Article Google Scholar
  9. Peiffer, S.L. et al. Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers. Cancer Res. 55, 1922–1926 (1995).
    PubMed CAS Google Scholar
  10. Gray, I.C. et al. Loss of chromosomal region 10q23-25 in prostate cancer. Cancer Res. 55, 4800–4803 (1995).
    PubMed CAS Google Scholar
  11. Trybus, T.M., Burgress, A.C., Wojno, K.J., Glover, T.W. & Macoska, J.A. Distinct areas of allelic loss on chromosomal regions 10p and 10q in human prostate cancer. Cancer Res. 56, 2263–2267 (1996).
    PubMed CAS Google Scholar
  12. Ransom, D.T. et al. Correlation of cytogenetic analysis and loss of heterozygosity studies in diffuse astrocytomas and mixed oligo-astrocytomas. Genes Chromosome. Cancer 5, 357–374 (1992).
    Article CAS Google Scholar
  13. Pershouse, M.A. et al. Analysis of the functional role of chromosome 10 loss in human glioblastomas. Cancer Res. 53, 5043–5050 (1993).
    PubMed CAS Google Scholar
  14. Steck, P.A., Hadi, A., Cheong, H.C., Yung, W.K.A. & Pershouse, M.A. Evidence for two tumour suppressive loci on chromosome 10 involved in glioblastomas. Genes Chromosome. Cancer 12, 255–261 (1995).
    Article CAS Google Scholar
  15. Church, D.M. et al. Isolation of genes from complex sources of mammalian genomic DNA using exon amplification. Nature Genet. 6, 98–105 (1994).
    Article CAS Google Scholar
  16. Tavtigian, S.V. et al. The complete BCRA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genet. 12, 333–337 (1996).
    Article CAS Google Scholar
  17. Kozak, M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15, 8125–8148 (1987).
    Article CAS Google Scholar
  18. Denu, J., Stuckey, J.A., Saper, D. & Dixon, J.E. Form and function in protein dephosphorylation. Cell 87, 361–364 (1996).
    Article CAS Google Scholar
  19. Denu, J.M. & Dixon, J.E. A catalytic mechanism for the dual-specific phosphatase. Proc. Natl. Acad. Sci. USA 92, 5910–5914 (1995).
    Article CAS Google Scholar
  20. Spruck, C.H. et al. p16 gene in uncultured tumours. Nature 370, 183–184 (1994).
    Article Google Scholar
  21. Herman, J.G. et al. Inactivation of the 2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res. 55, 4520–4530 (1995).
    Google Scholar
  22. Chou, P.Y. & Fassman-Fasman, G.D. Conformational parameters for amino acids in helical, beta-sheet, and random coil regions calculated from protein. Biochemistry 13, 211–222 (1974).
    Article CAS Google Scholar
  23. von Diemling, A. et al. Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme. J. Neurosurg. 77, 295–301 (1992).
    Article Google Scholar
  24. Tokiyoshi, K., Yoshimine, T., Maruno, M., Muhammad, A.K.M.G. & Hayakawa, T. Accumulation of allelic losses on chromosome 10 in human gliomas at recurrence. J. Clin. Pathol:Mol. Pathol. 49, 218–222 (1996).
    Google Scholar
  25. Nihei, N. et al. Localization of a metastasis suppressor gene(s) for rat prostatic cancer to the long arm of human chromosome 10. Genes Chromosome. Cancer 14, 112–119 (1995).
    Article CAS Google Scholar
  26. Albarosa, A., DiDonato, S. & Finocchiaro, G. Redefinition of the coding sequence of the MXI-1 gene and identification of a polymorphic repeat in the 3′ non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. Hum. Genet. 95, 709–711 (1995).
    Article CAS Google Scholar
  27. Nelen, M.R. et al. Localization of the gene for Cowdens disease to 10q22-23. Nature Genet. 13, 114–116 (1996).
    Article CAS Google Scholar
  28. Eng, C. et al. Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy? J. Med. Genet. 31, 458–461 (1994).
    Article CAS Google Scholar
  29. Teng, D.H.-F. et al. Low incidence of BRAC2 mutation in breast carcinoma and other cancers. Nature Genet. 13, 241–248 (1996).
    Article CAS Google Scholar
  30. Barford, D., Flint, A.J. & Tonks, N.K. Crystal structure of human protein tyrosine phosphatase 1b. Science 263, 1397–1404 (1994).
    Article CAS Google Scholar

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