Emerging targets for anti-inflammatory therapy (original) (raw)

Nature Cell Biology volume 1, pages E39–E40 (1999)Cite this article

Abstract

Cytokines mediate acute and chronic inflammatory processes in disease. A new target for anti-inflammatory therapy has now been revealed, in the form of a kinase that promotes translation of specific cytokine messenger RNA species into proteins.

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Figure 1: Regulation of cytokine genes by the p38 MAP-kinase pathway

References

  1. Han, J., Brown, T. & Beutler, B. J. Exp. Med. 171, 971– 972 (1990).
    Article Google Scholar
  2. Kontoyiannis, D., Pasparakis, M., Pizarro, T. T., Cominelli, F. & Kollias, G. Immunity 10, 387–398 (1999).
    Article CAS Google Scholar
  3. Han, J., Lee, J. D., Bibbs, L. & Ulevitch, R. J. Science 265, 808–811 (1994).
    Article CAS Google Scholar
  4. Lee, J. C. et al. Nature 372, 739–746 (1994).
    Article CAS Google Scholar
  5. Kotlyarov, A. et al. Nature Cell Biol. 1, 94– 97 (1999).
    Article CAS Google Scholar
  6. Rouse, J. et al. Cell 78, 1027–1037 (1994).
    Article CAS Google Scholar
  7. Freshney, N. W. et al. Cell 78, 1039–1049 (1994).
    Article CAS Google Scholar
  8. Gueydan, C. et al. J. Biol. Chem. 274, 2322– 2326 (1999).
    Article CAS Google Scholar
  9. Peng, S. S., Chen, C. Y., Xu, N. & Shyu, A. B. EMBO J. 17, 3461–3470 (1998).
    Article CAS Google Scholar
  10. Fan, X. C. & Steitz, J.A. EMBO J. 17, 3448–3460 (1998).
    Article CAS Google Scholar
  11. Carballo, E., Lai, W. S. & Blackshear, P. J. Science 281, 1001– 1005 (1998).
    Article CAS Google Scholar
  12. Deak, M., Clifton, A. D., Lucocq, L. M. EMBO J. 17, 4426– 4441 (1998).
    Article CAS Google Scholar

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Authors and Affiliations

  1. Department of Immunology, The Scripps Research Institute, La Jolla, 92037, California, USA
    J. Han & R. J. Ulevitch

Authors

  1. J. Han
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  2. R. J. Ulevitch
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Correspondence toR. J. Ulevitch.

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Han, J., Ulevitch, R. Emerging targets for anti-inflammatory therapy.Nat Cell Biol 1, E39–E40 (1999). https://doi.org/10.1038/10032

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