Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats (original) (raw)

• Takayama, H. et al. Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nat. Med. 1, 53–58 (1995).
  Article CAS Google Scholar
• Choi-Lundberg, D. L. et al. Dopaminergic neurons protected from degeneration by GDNF gene therapy . Science 275, 838– 841 (1997).
  Article CAS Google Scholar
• Deacon, T. et al. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat. Med. 3, 350–353 (1997).
  Article CAS Google Scholar
• Olanow, C. W., Kordower, J. H. & Freeman, T. B. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci. 19, 102 –109 (1996).
  Article CAS Google Scholar
• Wenning, G. K. et al. Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease. Ann. Neurol. 42, 95–107 (1997).
  Article CAS Google Scholar
• Kordower, J. H. et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N. Engl. J. Med. 332, 1118 –1124 (1995).
  Article CAS Google Scholar
• Johe, K. K., Hazel, T. G., Mü ller, T., Dugich-Djordjevic, M. M. & McKay, R. D. G.Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Devel. 10, 3129–3140 (1996).
  Article CAS Google Scholar
• McKay, R. D. Stem cells in the central nervous system. Science 276, 66–71 (1997).
  Article CAS Google Scholar
• Shah, N. M., Marchionni, M. A., Isaacs, I., Stroobant, P. & Anderson, D. J. Glial growth factor restricts mammalian neural crest stem cells to a glial fate. Cell 77, 349–360 (1994).
  Article CAS Google Scholar
• Shah, N. M., Groves, A. K. & Anderson, D. J. Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85, 331–343 (1996).
  Article CAS Google Scholar
• Suhonen, J. O., Peterson, D. A ., Ray, J. & Gage, F. H. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature 383, 624–627 (1996).
  Article CAS Google Scholar
• Frederiksen, K. & McKay, R. D. Proliferation and differentiation of rat neuroepithelial precursor cells in vivo. J. Neurosci. 8, 1144–1151 ( 1988).
  Article CAS Google Scholar
• Lendahl, U., Zimmerman, L. B. & McKay, R. D. CNS stem cells express a new class of intermediate filament protein. Cell 60, 585– 595 (1990).
  Article CAS Google Scholar
• Guyenet, P. G. & Crane, J. K. Non-dopaminergic nigrostriatal pathway. Brain Res. 213, 291– 305 (1981).
  Article CAS Google Scholar
• Rosenthal, A. Auto transplants for Parkinson's disease? Neuron 20, 169–172 (1998).
  Article CAS Google Scholar
• Spenger, C. et al. Fetal ventral mesencephalon of human and rat origin maintained in vitro and transplanted to 6-hydroxydopamine-lesioned rats gives rise to grafts rich in dopaminergic neurons. Exp. Brain Res. 112 , 47–57 (1996).
  Article CAS Google Scholar
• Lindvall, O. et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 247, 574– 577 (1990).
  Article CAS Google Scholar
• Jiao, S., Gurevich, V. & Wolff, J. A. Long-term correction of rat model of Parkinson's disease by gene therapy. Nature 362, 450–453 (1993).
  Article CAS Google Scholar
• Fisher, L. J., Jinnah, H. A., Kale, L. C., Higgins, G. A. & Gage, F. H. Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-Dopa. Neuron 6, 371–380 ( 1991).
  Article CAS Google Scholar
• Sabaté, O. et al. Transplantation to the rat brain of human neural progenitors that were genetically modified using adenoviruses . Nat. Genet. 9, 256– 260 (1995).
• Beck, K. D. et al. Mesencephalic dopaminergic neurons protected by GDNF from axotomy- induced degeneration in the adult brain. Nature 373, 339–341 (1995).
  Article CAS Google Scholar
• Tomac, A. et al. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373, 335– 339 (1995).
  Article CAS Google Scholar
• Crossley, P. H., Martinez, S. & Martin, G. R. Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66– 68 (1996).
  Article CAS Google Scholar
• Danielian, P. S. & McMahon, A. P. Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383, 332–334 (1996).
  Article CAS Google Scholar
• Hynes, M., Poulsen, K., Tessier-Lavigne, M. & Rosenthal, A. Control of neuronal diversity by the floor plate: Contact-mediated induction of midbrain dopaminergic neurons. Cell 80, 95–101 (1995).
  Article CAS Google Scholar
• Hynes, M. et al. Induction of midbrain dopaminergic neurons by sonic hedgehog. Neuron 15, 35–44 ( 1995).
  Article CAS Google Scholar
• Polymeropoulos, M. H. et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045–2047 (1997).
  Article CAS Google Scholar
• Zetterströ m, R. H. et al. Dopamine neuron agenesis in Nurr1-deficient mice. Science 276, 248–250 (1997).
  Article Google Scholar
• Hynes, M. et al. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19, 15–26 (1997).
  Article CAS Google Scholar
• Wang, M. Z. et al. Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. Nat. Med. 1, 1184– 1188 (1995).
  Article CAS Google Scholar
• Brü stle, O., Maskos, U. & McKay, R. D. G. Host-guided migration allows targeted introduction of neurons into the embryonic brain. Neuron 15, 1275–1285 (1995).
  Article Google Scholar
• Campbell, K., Olsson, M. & Bjö rklund, A. Regional incorporation and site-specific differentiation of striatal precursors transplanted to the embryonic forebrain ventricle. Neuron 15, 1259–1273 (1995).
  Article CAS Google Scholar
• Fishell, G. Striatal precursors adopt cortical identities in response to local cues. Development 121, 803–812 ( 1995).
  CAS Google Scholar
• Vicario-Abejó n, C., Cunningham, M. G. & McKay, R. D. G. Cerebellar precursors transplanted to the neonatal dentate gyrus express features characteristic of hippocampal neurons. J. Neurosci. 15, 6351–6363 (1995).
  Article Google Scholar
• Svendsen, C. N., Clarke, D. J., Rosser, A. E. & Dunnett, S. B. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Exp. Neurol. 137, 376– 388 (1996).
  Article CAS Google Scholar
• Svendsen, C. N. et al. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Exp. Neurol. 148, 135–146 (1997).
  Article CAS Google Scholar
• Brundin, P. et al. Survival and function of dissociated dopamine neurons grafted at different developmental stages or after being cultured in vitro. Dev. Brain Res. 39, 233–243 (1988).
  Article CAS Google Scholar
• Martinez-Serrano, A., Fischer, W. & Björklund, A. Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain. Neuron 15, 473 –484 (1995).
  Article CAS Google Scholar
• Snyder, E. Y., Taylor, R. M. & Wolfe, J. H. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature 374, 367–370 (1995).
  Article CAS Google Scholar
• Mayer-Proschel, M., Kalyani, A. J., Mujtaba, T. & Rao, M. S. Isolation of lineage-restricted neuronal precursors from multipotent neuroepithelial stem cells. Neuron 19, 773– 785 (1997)30.
  Article CAS Google Scholar
• Williams, B. P. et al. A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron 18, 553–562 (1997).
  Article CAS Google Scholar
• Studer, L. in Current Protocols in Neuroscience (eds Crawley, J. et al. ) 3.3.1–3.3.12 (Wiley, New York, 1997 ).
• Studer, L. et al. Non-invasive dopamine determination by reversed phase HPLC in the medium of free-floating roller tube cultures of rat fetal ventral mesencephalon. A tool to assess dopaminergic tissue prior to grafting. Brain Res. Bull. 41, 143–150 ( 1996).
  Article CAS Google Scholar
• Brustie, O., Cunningham, M.G., Tabar, V. & Studer L. in Current Protocols in Neuroscience (eds Crawley, J. et al. ) 3.10.1–3.10.28 (Wiley, New York, 1997).
• Gundersen, H. J. G. et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96, 379–394 (1988).
  Article CAS Google Scholar