Tryptophan tRNA of Escherichia coli (original) (raw)

Nature volume 228, page 57 (1970) Cite this article

Abstract

THE tryptophan tRNA of CAJ64, a UGA suppressing strain of _Escherichia coli_1, has an altered structure compared with that isolated from the wild type (CA244). A complete account of this work will be published elsewhere, but the sequence shown in Fig. 1 has two points of immediate interest. First, both the su+ and su− structures contain an adenosine at position 15 and a uridine at position 48. In most other tRNAs guanosine and cytosine, respectively, occupy homologous positions in the sequence. Another exception with adenosine and uridine in these positions has recently been found in a leucine tRNA of _E. coli_2. The three dimensional model proposed by Levitt3 has hydrogen bonds between the bases in these positions; these coordinate base changes are consistent with the structure and lend support to this feature of it.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 52 print issues and online access

$199.00 per year

only $3.83 per issue

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Sambrook, J. F., Fan, D. P., and Brenner, S., Nature, 214, 452 (1967).
    Article ADS CAS Google Scholar
  2. Dube, S. K., Marcker, K., and Yudelevich, A. (in the press).
  3. Levitt, M., Nature, 224, 759 (1969).
    Article ADS CAS Google Scholar
  4. Crick, F. H. C., J. Mol. Biol., 19, 548 (1966).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, England
    DAVID HIRSH

Rights and permissions

About this article

Cite this article

HIRSH, D. Tryptophan tRNA of Escherichia coli.Nature 228, 57 (1970). https://doi.org/10.1038/228057a0

Download citation