n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells (original) (raw)

Nature volume 268, pages 462–464 (1977)Cite this article

Abstract

LEDER and Leder1 have reported that low concentrations of _n_-butyrate cause Friend erythroleukaemia cells to begin globin synthesis. Apparently _n_-butyrate can reverse that part of viral transformation which prevents the expression of differentiation in these cells. Prasad and Sinha2 have summarised the effects of _n_-butyrate on neuroblastoma, HeLa, and other cell types. They and others3–10 have seen reversible inhibition of proliferation, decrease of DNA content, morphological modifications, and increases in the production of specific enzymes, such as adenylate cyclase, alkaline phosphatase, and a sialyltransferase. The present paper describes rapid, dramatic, and reversible increases in histone acetylation in the presence of _n_-butyrate.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Leder, A. & Leder, P. Cell 5, 319–322 (1975).
    Article CAS Google Scholar
  2. Prasad, K. N. & Sinha, P. K. In Vitro 12, 125–132 (1976).
    Article CAS Google Scholar
  3. Ginsburg, E., Salomon, D., Sreevalsan, T. & Freese, E. Proc. natn. Acad. Sci. U.S.A. 70, 2457–2461 (1973).
    Article ADS CAS Google Scholar
  4. Wright, J. A. Expl Cell Res. 78, 456–460 (1973).
    Article ADS CAS Google Scholar
  5. Griffin, M. J., Price, G. H., Bazzell, K. L., Cox, R. P. & Ghosh, N. K. Archs Biochem. Biophys. 164, 619–623 (1974).
    Article CAS Google Scholar
  6. Simmons, J. L., Fishman, P. H., Freese, E. & Brady, R. O. J. Cell Biol. 66, 414–424 (1975).
    Article CAS Google Scholar
  7. Ghosh, N. K., Deutsch, S. I., Griffin, M. J. & Cox, R. P. J. cell. Physiol. 86, 663–672 (1975).
    Article CAS Google Scholar
  8. Fishman, P. H., Bradley, R. M. & Henneberry, R. C. Archs Biochem. Biophys. 172, 618–626 (1976).
    Article CAS Google Scholar
  9. Altenburg, B. C., Via, D. P. & Steiner, S. M. Expl Cell Res. 102, 223–231 (1976).
    Article CAS Google Scholar
  10. Henneberry, R. C. & Fishman, P. H. Expl Cell Res. 103, 55–62 (1976).
    Article CAS Google Scholar
  11. Moss, B. A., Joyce, W. G. & Ingram, V. M. J. biol. Chem. 248, 1025–1031 (1973).
    CAS PubMed Google Scholar
  12. Alfageme, C. R., Zweidler, A., Mahowald, A. & Cohen, L. H. J. biol. Chem. 249, 3729–3736 (1974).
    CAS PubMed Google Scholar
  13. Ruiz-Carillo, A., Wangh, L. J. & Allfrey, V. G. Science 190, 117–128 (1975).
    Article ADS Google Scholar
  14. Gershey, E. L., Vidali, G. & Allfrey, V. G. J. biol. Chem. 243, 5018–5022 (1968).
    CAS PubMed Google Scholar
  15. Wong, T. K. & Marushige, K. Biochemistry 15, 2041–2046 (1976).
    Article CAS Google Scholar
  16. Thomas, G. & Hempel, K. Expl Cell Res. 100, 309–312 (1976).
    Article CAS Google Scholar
  17. Darzynkiewicz, Z., Traganos, F., Sharpless, T., Friend, C. & Melamed, M. R. Expl Cell Res. 99, 301–309 (1976).
    Article CAS Google Scholar
  18. Nudel, U. et al. Proc. natn. Acad. Sci. U.S.A. 74, 1100–1104 (1977).
    Article ADS CAS Google Scholar
  19. Moore, M. R. & Chalkley, R. Fedn Proc. 36, 785 (1977).
    Google Scholar
  20. Gusella, J., Geller, R., Clarke, B., Weeks, V. & Housman, D. Cell 9, 221–229 (1976).
    Article CAS Google Scholar
  21. Stanners, C. P., Eliceiri, G. L. & Green, H. Nature new Biol. 230, 52–54 (1971).
    Article ADS CAS Google Scholar
  22. Panyim, S., Bilek, D. & Chalkley, R. J. biol. Chem. 246, 4206–4215 (1971).
    CAS PubMed Google Scholar

Download references

Author information

Authors and Affiliations

  1. Biology Department, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, 02139
    M. G. RIGGS, R. G. WHITTAKER, J. R. NEUMANN & V. M. INGRAM

Authors

  1. M. G. RIGGS
    You can also search for this author inPubMed Google Scholar
  2. R. G. WHITTAKER
    You can also search for this author inPubMed Google Scholar
  3. J. R. NEUMANN
    You can also search for this author inPubMed Google Scholar
  4. V. M. INGRAM
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

RIGGS, M., WHITTAKER, R., NEUMANN, J. et al. _n_-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells.Nature 268, 462–464 (1977). https://doi.org/10.1038/268462a0

Download citation