Mutations of mitotic checkpoint genes in human cancers (original) (raw)
Boveri, T. Zur Frage der Entstehung maligner Tumoren vol. 1 (Gustav Fischer, Jena, 1914). Google Scholar
Loeb, L. A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res.51, 3075–3079 (1991). CASPubMed Google Scholar
Hartwell, L. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell71, 543–546 (1992). ArticleCAS Google Scholar
Perucho, M. Cancer of the microsatellite mutator phenotype. Biol. Chem.377, 675–684 (1996). CASPubMed Google Scholar
Modrich, P. Strand-specific mismatch repair in mammalian cells. J. Biol. Chem.272, 24727–24730 (1997). ArticleCAS Google Scholar
Kolodner, R. D. Mismatch repair — mechanisms and relationship to cancer susceptibility. Trends Biochem. Sci.20, 397–401 (1995). ArticleCAS Google Scholar
Kinzler, K. W. & Vogelstein, B. Lessons from hereditary colon cancer. Cell87, 159–170 (1996). ArticleCAS Google Scholar
Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instability in colorectal cancers. Nature386, 623–627 (1997). ArticleADSCAS Google Scholar
Strand, M., Prolla, T. A., Liskay, R. M. & Petes, T. D. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature365, 274–276 (1993). ArticleADSCAS Google Scholar
Murray, A. W. The genetics of cell cycle checkpoints. Curr. Opin. Genet. Dev.5, 5–11 (1995). ArticleCAS Google Scholar
Nasmyth, K. At the heart of the budding yeast cell cycle. Trends Genet.12, 405–412 (1996). ArticleCAS Google Scholar
Paulovich, A. G., Toczyski, D. P. & Hartwell, L. H. When checkpoints fail. Cell88, 315–321 (1997). ArticleCAS Google Scholar
Nicklas, R. B. How cells get the right chromosomes. Science275, 632–637 (1997). ArticleCAS Google Scholar
Li, R. & Murray, A. W. Feedback control of mitosis in budding yeast. Cell66, 519–531 (1991). ArticleCAS Google Scholar
Roberts, B. T., Farr, K. A. & Hoyt, M. A. The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol. Cell Biol.14, 8282–8291 (1994). ArticleCAS Google Scholar
Hardwick, K. G., Weiss, E., Luca, F. C., Winey, M. & Murray, A. W. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science273, 953–956 (1996). ArticleADSCAS Google Scholar
Pangilinan, F. & Spencer, F. Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast. Mol. Biol. Cell7, 1195–1208 (1996). ArticleCAS Google Scholar
Taylor, S. S. & McKeon, F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell89, 727–735 (1997). ArticleCAS Google Scholar
Hanks, S. K. & Quinn, A. M. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol.200, 38–62 (1991). ArticleCAS Google Scholar
Li, Y. & Benezra, R. Identification of a human mitotic checkpoint gene: hsMAD2. Science274, 246–248 (1996). ArticleADSCAS Google Scholar
Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W. & Friend, S. H. Integrating genetic approaches into the discovery of anticancer drugs. Science278, 1064–1068 (1997). ArticleADSCAS Google Scholar
Waldman, T., Lengauer, C., Kinzler, K. W. & Vogelstein, B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature381, 713–716 (1996). ArticleADSCAS Google Scholar
Polyak, K., Waldman, T., He, T.-C., Kinzler, K. W. & Vogelstein, B. Genetic determinants of p53 induced apoptosis and growth arrest. Genes Dev.10, 1945–1952 (1996). ArticleCAS Google Scholar
Liu, B.et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genet.9, 48–55 (1995). ArticleCAS Google Scholar
Lengauer, C.et al. Large-scale isolation of human 1p36-specific P1 clones and their use for fluorescence in situ hybridization. Genet. Anal. Tech. Appl.11, 140–147 (1994). ArticleCAS Google Scholar
Parsons, R.et al. Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res.55, 5548–5550 (1995). CASPubMed Google Scholar
Riggins, G. J., Kinzler, K. W., Vogelstein, B. & Thiagalingam, S. Frequency of Smad gene mutations in human cancers. Cancer Res.57, 2578–2580 (1997). CASPubMed Google Scholar
Jen, J.et al. Allelic loss of chromosome 18q and prognosis in colorectal cancer. N. Engl. J. Med.331, 213–221 (1994). ArticleCAS Google Scholar
Pangilinan, F.et al. Mammalian BUB1 protein kinases: map positions and in vivo expression. Genomics46, 379–388 (1997). ArticleCAS Google Scholar