Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant (original) (raw)

References

1. Sanders-Bush, E. & Mayer, S. E. in Goodman & Gilman's Pharmacological Basis of Therapeutics 9th edn (eds Hardman, J. G. et al.) 249–263 (McGraw-Hill, New York, 1996).
   Google Scholar
2. Leibowitz, S. F. & Alexander, J. T. Hypothalamic serotonin in control of eating behaviour, meal size, and body weight. Biol. Psychiatry 44, 851–864 (1998).
   Article CAS PubMed Google Scholar
3. Loer, C. M., Davidson, B. D. & McKerrow, J. M. A phenylalanine hydroxylase gene from the nematode C. elegans is expressed in the hypodermis. J. Neurogenet. 13, 157–180 (1999).
   Article CAS PubMed Google Scholar
4. D'Sa, C. M., Arthur, R. E. Jr & Kuhn, D. M. Expression and deletion mutagenesis of tryptophan hydroxylase fusion proteins: delineation of the enzyme catalytic core. Neurochem. 67, 917–926 (1996).
   Article CAS Google Scholar
5. Rand, J. B. & Nonet, M. L. Synaptic Transmission in C. elegans II (eds Riddle, D. L. et al.) 611–643 (Cold Spring Harbor Laboratory Press, New York, 1997).
   Google Scholar
6. Jansen, G., Hazendonk, E., Thijssen, K. L. & Plasterk, R. H. Reverse genetics by chemical mutagenesis in C. elegans. Nature Genet. 17, 119–121 (1997).
   Article CAS PubMed Google Scholar
7. Horvitz, H. R., Chalfie, M., Trent, C., Sulston, J. E. & Evans, P. D. Serotonin and octopamine in the nematode C. elegans. Science 216, 1012–1014 (1982).
   Article ADS CAS PubMed Google Scholar
8. Avery, L. & Horvitz, H. R. Effects of starvation and neuroactive drugs on feeding in C. elegans. J. Exp. Zool. 253, 263–270 (1990).
   Article CAS PubMed Google Scholar
9. Sulston, J., Dew, M. & Brenner, S. Dopaminergic neurons in the nematode Caenorhabditis elegans. J. Comp. Neuro. 163, 215–226 (1975).
   Article CAS Google Scholar
10. Weinshenker, D, Garriga, G. & Thomas, J. H. Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans. J. Neurosci 15, 6975–6985 (1995).
    Article CAS PubMed PubMed Central Google Scholar
11. Waggoner, L. E., Zhou, G. T., Schafer, R. W. & Schafer, W. R. Control of alternative behavioural states by serotonin in Caenorhabditis elegans. Neuron 21, 203–214 (1998).
    Article CAS PubMed Google Scholar
12. Duerr, J. S. et al. The cat-1 gene of Caenorhabditis elegans encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviours. J. Neurosci. 19, 72–84 (1999).
    Article CAS PubMed PubMed Central Google Scholar
13. Riddle, D. L. Genetic and Environmental Regulation of Dauer Larva Development in C. elegans II. (eds Riddle, D. L. et al.) 739–768 (Cold Spring Harbor Laboratory Press, New York, 1997).
    Google Scholar
14. Kimura, K. D., Tissenbaum, H. A., Liu, Y. & Ruvkun, G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans. Science 277, 942–946 (1997).
    Article CAS PubMed Google Scholar
15. Ren, P. F. et al. Control of C. elegans larval development by neuronal expression of a TGF-β homolog. Science 274, 1389–1391 (1996).
    Article ADS CAS PubMed Google Scholar
16. Schackwitz, W. S., Inoue, T. & Thomas, J. H. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron 17, 719–728 (1996).
    Article CAS PubMed Google Scholar
17. Bargmann, C. Neurobiology of the C. elegans genome. Science 282, 2028–2033 (1998).
    Article ADS CAS PubMed Google Scholar
18. Zwaal, R. R., Mendel, J. E., Sternberg, P. W. & Plasterk, R. H. A. Two neuronal G proteins are involved in chemosensation of the C. elegans dauer-inducing pheromone. Genetics 145, 715–727 (1997).
    CAS PubMed PubMed Central Google Scholar
19. Ogg, S. et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994–999 (1997).
    Article ADS CAS PubMed Google Scholar
20. Patterson, G. I., Koweek, A., Wong, A., Liu, Y. & Ruvkun, G. The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the C. elegans dauer pathway. Genes Dev. 11, 2679–2690 (1997).
    Article CAS PubMed PubMed Central Google Scholar
21. Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R. A. C. elegans mutant that lives twice as long as wild type. Nature 366, 461–464 (1993).
    Article ADS CAS PubMed Google Scholar
22. Gems, D. et al. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behaviour, reproduction and longevity in Caenorhabditis elegans. Genetics 150, 129–155 (1998).
    CAS PubMed PubMed Central Google Scholar
23. Conradt, B. & Horvitz, H. R. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93, 519–529 (1998).
    Article CAS PubMed Google Scholar
24. Duret, L. Gues, N., Peitsch, M. & Bairoch, A. New insulin-like proteins with atypical disulfide bond pattern characterized in C. elegans by comparative sequence analysis and homology modeling. Genome Res. 8, 348–353 (1998).
    Article CAS PubMed Google Scholar
25. Peschke, E., Peschke, D., Hammer, T. & Csernus, V. Influence of melatonin and serotonin on glucose-stimulated insulin release from perifused rat pancreatic islets in vitro. J. Pineal Res. 23, 156–163 (1997).
    Article CAS PubMed Google Scholar
26. Breum, L., Bjerre, U., Bak, J. F., Jacobsen, S. & Astrup, A. Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance: influence on muscle glycogen synthase and insulin receptor kinase activity. Metabolism 44,1570–1576 (1995).
27. Avery, L. The genetics of feeding in Caenorhabditis elegans. Genetics 133, 897–917 (1993).
    CAS PubMed PubMed Central Google Scholar
28. Lakowski, B. & Hekimi, S. The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 95,13091–13096 (1998).
29. Nonogaki, K., Strack, A. M., Dallman, M. F. & Tecott, L. H. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nature Med. 4, 1152–1156 (1998).
    Article CAS PubMed Google Scholar
30. Barzilai, A., Kennedy, T. E., Sweatt, J. D. & Kandel, E. R. 5-HT modulates protein synthesis and the expression of specific proteins during long-term facilitation in Aplysia sensory neurons. Neuron 2, 1577–1586 (1989).
    Article CAS PubMed Google Scholar

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