PDGF-C is a new protease-activated ligand for the PDGF α-receptor (original) (raw)

• Raines, E. W., Bowen-Pope, D. F. & Ross, R. in Handbook of Experimental Pharmacology: Peptide Growth Factors and their Receptors Vol. I (eds Sporn, M. B. & Roberts, A. B.) 173–262 (Springer, New York, 1990).
• Heldin, C. H., Östman, A. & Rönnstrand, L. Signal transduction via platelet-derived growth factor receptors. Biochim. Biophys. Acta 1378 , F79–F113 (1998).
  CAS PubMed Google Scholar
• Ataliotis, P. & Mercola, M. Distribution and functions of platelet-derived growth factors and their receptors during embryogenesis. Int. Rev. Cytol. 172, 95–127 (1997).
  Article CAS Google Scholar
• Betsholtz, C., Westermark, B., Ek, B. & Heldin, C.-H. Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation. Cell 39, 447–457 (1984).
  Article CAS Google Scholar
• Keating, M. T. & Williams, L. T. Autocrine stimulation of intracellular PDGF receptors in v-sis transformed cells. Science 239, 914–916 (1988).
  Article CAS Google Scholar
• Heldin, C. H. & Westermark, B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79, 1283–1316 (1999).
  Article CAS Google Scholar
• Lindahl, P. & Betsholtz, C. Not all myofibroblasts are alike: revisiting the role of PDGF-A and PDGF-B using PDGF-targeted mice. Curr. Opin. Nephrol. Hypertens. 7, 21– 26 (1998).
  Article CAS Google Scholar
• Lindahl, P. et al. Role of platelet-derived growth factors in angiogenesis and alveogenesis. Curr. Top. Pathol. 93, 27– 33 (1999).
  Article CAS Google Scholar
• Boström, H. et al. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 85, 863 –873 (1996).
  Article Google Scholar
• Karlsson, L., Bondjers, C. & Betsholtz, C. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126, 2611–2621 (1999).
  CAS PubMed Google Scholar
• Fruttiger, M. et al. Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. Development 126, 457–467 (1999).
  CAS PubMed Google Scholar
• Soriano, P. The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites. Development 124 , 2691–2700 (1997).
  CAS PubMed Google Scholar
• Levéen, P . et al. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev. 8, 1875–1887 (1994).
  Article Google Scholar
• Soriano, P. Abnormal kidney development and hematological disorders in PDGFβ-receptor mutant mice. Genes Dev. 8, 1888– 1896 (1994).
  Article CAS Google Scholar
• Lindahl, P. et al. Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development 125, 3313–3322 (1998).
  CAS PubMed Google Scholar
• Lindahl, P., Johansson, B. R., Levéen, P. & Betsholtz, C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277, 242–245 (1997).
  Article CAS Google Scholar
• Bork, P. Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats. FEBS Lett. 282, 9–12 (1991).
  Article CAS Google Scholar
• Östman, A. et al. Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: evidence for difference in receptor binding and functional activities. Growth Factors 1, 271–281 (1989).
  Article Google Scholar
• Subramaniam, A. et al. Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J. Biol. Chem. 266 , 24613–24620 (1991).
  CAS PubMed Google Scholar
• Simm, A., Nestler, M. & Hoppe, V. Mitogenic effect of PDGF-AA on cardiac fibroblasts. Basic Res. Cardiol. 93, Suppl 3, 40–43 (1998).
• Vainio, S. & Muller, U. Inductive tissue interactions, cell signaling, and the control of kidney organogenesis. Cell 90, 975–978 (1997).
  Article CAS Google Scholar
• Oefner, C., D’Arcy, A., Winkler, F.K., Eggimann, B. & Hosang, M. Crystal structure of human platelet-derived growth factor BB. EMBO J. 11, 3921–3926 (1992).
  Article CAS Google Scholar
• Östman, A., Thyberg, J., Westermark, B. & Heldin, C.-H. PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly. J. Cell Biol. 118, 509–519 (1992).
  Article Google Scholar
• Nakayama, K. Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. Biochem. J. 327, 625–635 (1997).
  Article CAS Google Scholar
• Bork, P. & Beckmann, G. The CUB domain. A widespread module in developmentally regulated proteins. J. Mol. Biol. 231, 539–545 (1993).
  Article CAS Google Scholar
• Moestrup, S. K. et al. The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. J. Biol. Chem. 273, 5235–5242 (1998).
  Article CAS Google Scholar
• Nakamura, F., Tanaka, M., Takahashi, T., Kalb, R. G. & Strittmatter, S. M. Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse. Neuron 21, 1093–1100 (1998).
  Article CAS Google Scholar
• Giger, R.J. et al. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Neuron 21, 1079–1092 (1998).
  Article CAS Google Scholar
• Kristiansen, M. et al. Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding . J. Biol. Chem. 274, 20540– 20544 (1999).
  Article CAS Google Scholar
• Thielens, N. M., Bersch, B., Hernandez, J. F. & Arlaud, G. J. Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex. Immunopharmacology 42, 3–13 (1999).
  Article CAS Google Scholar
• Andersson, M., Östman, A., Westermark, B. & Heldin, C.-H. Characterization of the retention motif in the C-terminal part of the long splice form of platelet-derived growth factor A-chain. J. Biol. Chem. 269, 926– 930 (1994).
  CAS PubMed Google Scholar
• Pekny, M. et al. Differences in binding to the solid substratum and extracellular matrix may explain isoform-specific paracrine effects of platelet-derived growth factor. Growth Factors 10, 77– 87 (1994).
  Article CAS Google Scholar
• Park, J. E., Keller, G. A. & Ferrara, N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4, 1317–1326 (1993).
  Article CAS Google Scholar
• Hauser, S. & Weich, H. A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. Growth Factors 9, 259– 268 (1993).
  Article CAS Google Scholar
• Olofsson, B. et al. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc. Natl Acad. Sci. USA 93, 2576–2581 (1996).
  Article CAS Google Scholar
• Eriksson, U. & Alitalo, K. Structure, expression and receptor-binding properties of novel vascular endothelial growth factors. Curr. Top. Microbiol. Immunol. 237, 41–57 (1999).
  CAS PubMed Google Scholar
• Green, S., Issemann, I. & Sheer, E. A versatile in vivo and in vitro eucaryotic expression vector for protein engineering. Nucleic Acid Res. 16, 369 (1988).
  Article CAS Google Scholar
• Heldin, C.-H. et al. Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J. 7 , 1387–1393 (1988).
  Article CAS Google Scholar
• Eriksson, A., Siegbahn, A., Westermark, B., Heldin, C.-H. & Claesson-Welsh, L. PDGFα- and β-receptors activate unique and common signal transduction pathways. EMBO J. 11, 543–550 (1992).
  Article CAS Google Scholar
• Mori, S., Claesson-Welsh, L. & Heldin, C. H. Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor beta-receptor which is important for ligand-mediated endocytosis. J. Biol. Chem. 266 , 21158–21164 (1991).
  CAS PubMed Google Scholar
• Evan, G. I., Lewis, G. K., Ramsay, G. & Bishop, J. M. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell Biol. 3610–3616 (1985).
• Chomczynski, P. & Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction . Anal. Biochem. 162, 156– 159 (1987).
  Article CAS Google Scholar
• Betsholtz, C. et al. cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 320, 695–699 (1986).
  Article CAS Google Scholar