DNA methylation in Drosophila melanogaster (original) (raw)
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- Published: 30 November 2000
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Nature volume 408, pages 538–540 (2000)Cite this article
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Abstract
Certain cytosine residues of eukaryotic DNA are methylated in inactive regions of the genome. For a long time the fruitfly Drosophila was thought to be an exception1,2,3,4, but now the evidence points to the existence of a functional DNA-methylation system in Drosophila as well5,6,7,9. Here we show that DNA is methylated, but that Drosophila genomic methylation is restricted to the early stages of embryonic development.
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Figure 1: Methylation analysis of Drosophila genomic DNA from wild-type (Oregon R) flies.
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Authors and Affiliations
- Whitehead Institute for Biomedical Research, Cambridge, 02142, Massachusetts, USA
Frank Lyko & Rudolf Jaenisch - Department of Oncology, John Hughes Bennett Laboratory, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
Bernard H. Ramsahoye - Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA
Rudolf Jaenisch
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- Frank Lyko
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Correspondence toRudolf Jaenisch.
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Lyko, F., Ramsahoye, B. & Jaenisch, R. DNA methylation in Drosophila melanogaster .Nature 408, 538–540 (2000). https://doi.org/10.1038/35046205
- Issue Date: 30 November 2000
- DOI: https://doi.org/10.1038/35046205