A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans (original) (raw)
References
Hengartner, M. O., Ellis, R. E. & Horvitz, H. R. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature356, 494–499 (1992). ArticleCASPubMed Google Scholar
Hengartner, M. O. & Horvitz, H. R. C. elegans cell survival gene ced-9 encodes a functional homologue of the mammalian proto-oncogene bcl-2. Cell76, 665–676 (1994). ArticleCASPubMed Google Scholar
Hengartner, M. O. & Horvitz, H. R. Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2. Nature369, 318–320 (1994). ArticleCASPubMed Google Scholar
Vaux, D. L, Weissman, I. L., & Kim, S. K. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science258, 1955–1957 (1992). ArticleCASPubMed Google Scholar
Conradt, B. & Horvitz, H. R. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell93, 519 –529 (1998). ArticleCASPubMed Google Scholar
Ellis, H. M. & Horvitz, H. R. Genetic control of programmed cell death in the nematode C. elegans. Cell44, 817–829 ( 1986). ArticleCASPubMed Google Scholar
Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. & Horvitz, H. R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell75, 641–652 (1993). ArticleCASPubMed Google Scholar
Xue, D., Shaham S. & Horvitz, H. R. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev.10, 1073–1083 (1996). ArticleCASPubMed Google Scholar
Shaham, S. & Horvitz, H. R. An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Cell86, 201–208 ( 1996). ArticleCASPubMed Google Scholar
Zou, H., Henzel, W. J., Liu, X., Lutschg, A. & Wang, X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome _c_-dependent activation of caspase-3. Cell90, 405– 413 (1997). ArticleCASPubMed Google Scholar
Hedgecock, E. M., Sulston, J. E. & Thomson, J. N. Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans. Science220, 1277–1279 (1983). ArticleCASPubMed Google Scholar
Ellis, R. E., Jacobson, D. M. & Horvitz, H. R. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics129, 79–94 ( 1993). Google Scholar
Driscoll, M. & Chalfie, M. The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. Nature349, 588–593 (1991). ArticleCASPubMed Google Scholar
Hong, K. & Driscoll, M. A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans. Nature367, 470– 473 (1994). ArticleCASPubMed Google Scholar
Treinin, M. & Chalfie, M. A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans. Neuron14, 871–877 ( 1995). ArticleCASPubMed Google Scholar
Treinin, M., Gillo, B. Liebman, L. & Chalfie, M. Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon. Proc. Natl Acad. Sci. USA95, 15492–15495 (1998). ArticleCASPubMedPubMed Central Google Scholar
Chalfie, M. & Sulston, J. Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans. Dev. Biol.82, 358–370 ( 1981). ArticleCASPubMed Google Scholar
Hall, D. H., et al., Neuropathology of degenerative cell death in Caenorhabditis elegans. J. Neurosci.17, 1033– 1045 (1992). Article Google Scholar
Schulze-Osthoff, K. et al. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J. Biol. Chem.267, 5317–5323 (1992). CASPubMed Google Scholar
Dunn, W. A. Autophagy and related mechanisms of lysosome-mediated protein degradation . Trends Cell Biol.4, 139– 143 (1994). ArticleCASPubMed Google Scholar
Kane, D. J., Ord, T., Anton, R. & Bredesen, D. E. Expression of bcl-2 inhibits necrotic neural cell death. J. Neurosci. Res.40, 269–275 ( 1995). ArticleCASPubMed Google Scholar
Vaux, D. L., Whitney, D. & Weismann, I. L. Activation of physiological cell death mechanisms by a necrosis-causing agent. Microsc. Res. Tech.34 , 259–266 (1996). ArticleCASPubMed Google Scholar
Shimizu, S. et al. Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene12, 2045–2050 (1996). CASPubMed Google Scholar
Okuno, S. I. et al. Bcl-2 prevents caspase-independent cell death. J. Biol. Chem.273, 34272–34277 (1998). ArticleCASPubMed Google Scholar
Shaham, S. & Horvitz, H. R. Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities . Genes Dev.10, 578–591 (1996). ArticleCASPubMed Google Scholar
Shaham, S., Reddien, P.W., Davies, B., & Horvitz, H.R. Mutational analysis of the C. elegans cell death gene ced-3. Genetics153, 1655–1671 ( 1999). CASPubMedPubMed Central Google Scholar
Robertson, A. M. G. & Thomson, J. N. Morphology of programmed cell death in the ventral cord of Caenorhabditis elegans . J. Embryol. Exp. Morphol.67, 89– 100 (1982). Google Scholar
Moynault, A., Luciani, M. F. & Chimini, G. ABC1, the mammalian homologue of the engulfment gene ced-7, is required during phagocytosis of both necrotic and apoptotic cells. Biochem. Soc. Trans.26, 629– 635 (1998). ArticleCASPubMed Google Scholar
Chalfie, M. & Wolinsky, E. The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans . Nature345, 410–416 (1990). ArticleCASPubMed Google Scholar
Korswagen, H. C., Park, J-H., Ohshima, Y., & Plasterk, R. H. A. An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration. Genes Dev.11, 1493 –1503 (1997). ArticleCASPubMed Google Scholar
Berger, A. J., Hart, A. C. & Kaplan, J. M. G-α(s)-induced neurodegeneration in Caenorhabditis elegans. J. Neurosci.18, 2871–2888 (1998). ArticleCASPubMedPubMed Central Google Scholar
Wu, Y. C. & Horvitz H. R. The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. Cell93, 951– 960 (1998). ArticleCASPubMed Google Scholar
Reddien, P. W. & Horvitz, H. R. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nature Cell Biol2, 131– 136 (2000). ArticleCASPubMed Google Scholar
Wu, Y. C. & Horvitz, H. R. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180 . Nature392, 501–504 (1998). ArticleCASPubMed Google Scholar
Vercammen, D. et al., Dual signaling of the FAS receptor: initiation of both apoptotic and necrotic cell death pathways. J. Exp. Med.18, 919–930 (1998). Article Google Scholar
Kawahara, A., Ohsawa, Y., Matsumura, H., Uchiyama, Y. & Nagata, S. Caspase-independent cell killing by Fas-associated protein with death domain. J. Cell Biol.143, 1353–1360 (1998). ArticleCASPubMedPubMed Central Google Scholar
Chautan, M., Chazal, G., Cecconi, F., Gruss, P. & Goldstein, P. Interdigital cell death can occur through a necrotic and caspase-independent pathway. Curr. Biol.9, 967–970 (1999). ArticleCASPubMed Google Scholar
Brown, S. B., Clarke, M. C. H., Magowan, L., Sanderson, H. & Savill, J. Constitutive death of platelets leading to scavanger-mediated phagocytosis. J. Biol. Chem.275, 5987–5996 ( 2000). ArticleCASPubMed Google Scholar
Savill, J., Fadok, V., Henson, P. & Haslett, C. Phagocyte recognition of cells undergoing apoptosis. Immunol. Today14, 131–136 (1993). ArticleCASPubMed Google Scholar
Hart, S. P., Haslett, C. & Dransfield, I. Recognition of apoptotic cells by phagocytes. Experientia52, 950–956 (1996). ArticleCASPubMed Google Scholar
Fadok, V. A., Bratton, D. Frasch, S. C., Warner, M. L. & Henson, P. H., The role of phosphatidylserine in recognition of apoptotic cells by phagocytes. Cell Death. Diff.5, 551–562 ( 1998). ArticleCAS Google Scholar
Liu, Q. A. & Hengartner, M. O. Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans . Cell93, 961–972 (1998). ArticleCASPubMed Google Scholar
Sulston, J. E., Schierenberg, E., White, J. G. & Thomson, J. N. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol.100, 64– 119 (1983). ArticleCASPubMed Google Scholar
Sulston, J. E. & Horvitz, H. R. Post embryonic cell lineages of the nematode Caenorhabditis elegans. Dev. Biol.56, 110–156 ( 1977). ArticleCASPubMed Google Scholar
Kimble, J. & Hirsh, D. The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans . Dev. Biol.70, 396– 417 (1979). ArticleCASPubMed Google Scholar
Driscoll, M. Methods for the study of cell death in the nematode Caenorhabditis elegans . Methods Cell Biol.46, 323– 353 (1995). ArticleCASPubMed Google Scholar
Avery, L. & Horvitz, H. R. A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant. Cell51, 1071– 1078 (1987). ArticleCASPubMedPubMed Central Google Scholar
Yuan, J. & Horvitz, H. R. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development116, 309–320 ( 1992). CASPubMed Google Scholar
Garcia-Anoveros, J., Ma, C. & Chalfie, M. Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain. Curr. Biol.5, 441–448 (1995). ArticleCASPubMed Google Scholar