The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis (original) (raw)
Weinert, T. DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. Cell94, 555–558 (1998). ArticleCAS Google Scholar
Hartwell, L. H. & Kastan, M. B. Cell cycle control and cancer. Science266, 1821–1828 (1994). ArticleADSCAS Google Scholar
Elledge, S. J. Cell cycle checkpoints: preventing an identity crisis. Science274, 1664–1672 (1996). ArticleADSCAS Google Scholar
Painter, R. B. & Young, B. R. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl Acad. Sci. USA77, 7315–7317 (1980). ArticleADSCAS Google Scholar
Rotman, G. & Shiloh, Y. ATM: a mediator of multiple responses to genotoxic stress. Oncogene18, 6135–6144 (1999). ArticleCAS Google Scholar
Stewart, G. S. et al. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell99, 577–587 (1999). ArticleCAS Google Scholar
Galaktionov, K. & Beach, D. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell67, 1181–1194 (1991). ArticleCAS Google Scholar
Hoffmann, I., Draetta, G. & Karsenti, E. Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J.13, 4302–4310 (1994). ArticleCAS Google Scholar
Jinno, S. et al. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J.13, 1549–1556 (1994). ArticleCAS Google Scholar
Mailand, N. et al. Rapid destruction of Cdc25A in response to DNA damage. Science288, 1425–1429 (2000). ArticleADSCAS Google Scholar
Molinari, M. et al. Human Cdc25A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Reps1, 71–79 (2000). ArticleCAS Google Scholar
Matsuoka, S., Huang, M. & Elledge, S. J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science282, 1893–1897 (1998). ArticleADSCAS Google Scholar
Bell, D. W. et al. Heterozygous germ line hCHK2 mutations in Li–Fraumeni syndrome. Science286, 2528–2531 (1999). ArticleCAS Google Scholar
Gu, Y., Rosenblatt J. & Morgan, D. O. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J.11, 3995–4005 (1992). ArticleCAS Google Scholar
Boddy, M. N., Furnari, B., Mondesert, O. & Russell, P. Replication checkpoint enforced by kinases Cds1 and Chk1. Science280, 909–912 (1998). ArticleADSCAS Google Scholar
Furnari, B., Rhind, N. & Russell, P. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science277, 1495–1497 (1997). ArticleCAS Google Scholar
Peng, C. Y. et al. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science277, 1501–1505 (1997). ArticleCAS Google Scholar
Sanchez, Y. et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science277, 1497–1501 (1997). ArticleCAS Google Scholar
Zeng, Y. et al. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature395, 507–510 (1998). ArticleADSCAS Google Scholar
Chehab, N. H., Malikzay, A., Appel, M. & Halazonetis, T. D. Chk2/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53. Genes Dev.14, 278–288 (2000). CASPubMedPubMed Central Google Scholar
Sun, Z., Hsiao, J., Fay, D. S. & Stern, D. F. Rad 53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science281, 272–274 (1998). ArticleADSCAS Google Scholar
Durocher, D., Henckel, J., Fersht, A. R. & Jackson, S. P. The FHA domain is a modular phosphopeptide recognition motif. Mol. Cell4, 387–394 (1999). ArticleCAS Google Scholar
Hirao, A. et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science287, 1824–1827 (2000). ArticleADSCAS Google Scholar
Chan, T. A., Hermeking, H., Lengauer, C., Kinzler, K. W. & Vogelstein, B. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage. Nature401, 616–620 (1999). ArticleADSCAS Google Scholar
Giaccia, A. J. & Kastan, M. B. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev.12, 2973–2983 (1998). ArticleCAS Google Scholar
Lim, D. S. et al. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature404, 613–617 (2000). ArticleADSCAS Google Scholar
Xie, G. et al. Requirements for p53 and ATM gene product in the regulation of G1/S and S phase checkpoints. Oncogene16, 721–736 (1998). ArticleCAS Google Scholar
Galaktionov, K. et al. CDC25 phosphatases as potential human oncogenes. Science269, 1575–1577 (1995). ArticleADSCAS Google Scholar
Lee, J. S., Collins, K. M., Brown, A. L., Lee, C. H. & Chung, J. H. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature404, 201–204 (2000). ArticleADSCAS Google Scholar
Santoni-Rugiu, E., Falck, J., Mailand, N., Bartek, J & Lukas, J. Involvement of Myc activity in a G1/S-promoting mechanism parallel to the pRb/E2F pathway. Mol. Cell. Biol.20, 3497–3509 (2000). ArticleCAS Google Scholar