A second-generation linkage map of the human genome (original) (raw)

• Article
• Published: 29 October 1992
• Gabor Gyapay1,3,
• Colette Dib1,
• Alain Vignal1,
• Jean Morissette1,4,
• Philippe Millasseau1,3,
• Guy Vaysseix1 &
• …
• Mark Lathrop3,5

Nature volume 359, pages 794–801 (1992)Cite this article

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Abstract

A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to ∼90% of the estimated length of the human genome.

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Authors and Affiliations

1. Genethon, 1 rue de I'lnternationale, 91000, Evry, France
   Jean Weissenbach, Gabor Gyapay, Colette Dib, Alain Vignal, Jean Morissette, Philippe Millasseau & Guy Vaysseix
2. Unité de Génétique Moléculaire Humaine, CNRS LIRA 1445, Institut Pasteur, 75724, Paris cédex, France
   Jean Weissenbach
3. Centre d'Etudes du Polymorphisme Humain (CEPH), Centre Hospitalier de I'Université Laval, Québec, Canada
   Gabor Gyapay, Philippe Millasseau & Mark Lathrop
4. Réseau de Médecine Génétique, Centre Hospitalier de I'Université Laval, Québec, Canada
   Jean Morissette
5. INSERM U 358, 27 Rue Juliette Dodu, 75010, Paris, France
   Mark Lathrop

Authors

1. Jean Weissenbach
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2. Gabor Gyapay
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3. Colette Dib
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4. Alain Vignal
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5. Jean Morissette
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6. Philippe Millasseau
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7. Guy Vaysseix
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8. Mark Lathrop
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Weissenbach, J., Gyapay, G., Dib, C. et al. A second-generation linkage map of the human genome.Nature 359, 794–801 (1992). https://doi.org/10.1038/359794a0

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• Received: 25 September 1992
• Accepted: 08 October 1992
• Issue Date: 29 October 1992
• DOI: https://doi.org/10.1038/359794a0

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