Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone (original) (raw)

References

  1. Ihle, J. N. et al. Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem. Sci. 19, 222–227 (1994).
    Article CAS Google Scholar
  2. Argetsinger, L. S. et al. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74, 237–244 (1993).
    Article CAS Google Scholar
  3. Frank, S. J. et al. Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor. J. Biol. Chem. 270, 14765–14785 (1995).
    Google Scholar
  4. Winston, L. A. & Hunter, T. JAK2, Ras, Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. J. Biol. Chem. 270, 30837–30840 (1995).
    Article CAS Google Scholar
  5. Han, Y. et al. Participation of JAK and STAT proteins in growth hormone-inducing signaling. J. Biol. Chem. 271, 5947–5952 (1996).
    Article CAS Google Scholar
  6. Ihle, J. N. STATs and MAPKs: obligate or opportunistic partners in signaling. BioEssays 18, 95–98 (1996).
    Article CAS Google Scholar
  7. Burgering, B. M. T. & Bos, J. L. Regulation of Ras-mediated signalling: more than one way to skin a cat. Trends Biochem. Sci. 20, 18–22 (1995).
    Article CAS Google Scholar
  8. van Biesen, T. et al. Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway. Nature 376, 781–784 (1995).
    Article ADS CAS Google Scholar
  9. VanderKuur, J., Allevato, G., Billestrup, N., Norstedt, G. & Carter-Su, C. Growth hormone-promoted tyrosyl phosphorylation of Shc proteins and Shc association with Grb2. J. Biol. Chem. 270, 7587–7593 (1995).
    Article CAS Google Scholar
  10. Ridderstrale, M., Degerman, E. & Tornqvist, H. Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes. J. Biol. Chem. 270, 3471–3474 (1995).
    Article CAS Google Scholar
  11. Argetsinger, L. S. et al. Growth hormone, interferon-γ, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270, 14685–14692 (1995).
    Article CAS Google Scholar
  12. Argetsinger, L. S., Norstedt, G., Billestrup, N., White, M. F. & Carter-Su, C. Growth hormone, interferon-γ, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling. J. Biol. Chem. 271, 29415–29421 (1996).
    Article CAS Google Scholar
  13. Tamemoto, H. et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372, 182–186 (1994).
    Article ADS CAS Google Scholar
  14. Araki, E. et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372, 186–190 (1994).
    Article ADS CAS Google Scholar
  15. Yamauchi, T. et al. Insulin signalling and insulin actions in the muscle and liver of insulin resistant IRS-1 deficient mice. Mol. Cell. Biol. 16, 3074–3084 (1996).
    Article CAS Google Scholar
  16. Miyake, S. et al. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc. Natl Acad. Sci. USA 93, 1320–1324 (1996).
    Article ADS CAS Google Scholar
  17. Sekine, N., Ullrich, S., Regazzi, R., Pralong, W. F. & Wollheim, C. B. Postreceptor signaling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1. Endocrinology 137, 1841–1850 (1996).
    Article CAS Google Scholar
  18. Batzer, A. G., Rotin, D., Urena, J. M., Skolnik, E. Y. & Schlessinger, J. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol. Cell. Biol. 14, 5192–5201 (1994).
    Article CAS Google Scholar
  19. Okutani, T. et al. Grb2/Ash binds directly to tyrosine 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. J. Biol. Chem. 269, 31310–31314 (1994).
    CAS Google Scholar
  20. Chen, C., Clarkson, R. W. E., Xie, Y., Hume, D. A. & Waters, J. M. Growth hormone and colony-stimulating factor-1 share multiple response elements in the c-fos promoter. Endocrinology 136, 4505–4516 (1995).
    Article CAS Google Scholar
  21. Wen, Z., Zhong, Z. & Darnell, J. E. J Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82, 241–250 (1995).
    Article CAS Google Scholar
  22. Gille, H., Sharrocks, A. D. & Shaw, P. E. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358, 414–417 (1992).
    Article ADS CAS Google Scholar
  23. Watanabe, S., Itoh, T. & Arai, K. JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells. J. Biol. Chem. 271, 12681–12686 (1996).
    Article CAS Google Scholar
  24. Luttrell, L. M., Rocca, G. J. D., Biesen, T. V., Luttrel, D. K. & Lefkowitz, R. J. Gβγ subunits mediate src-dependent phosphorylation of the epidermal growth factor receptor. J. Biol. Chem. 272, 4637–4644 (1997).
    Article CAS Google Scholar
  25. Sachsenmaier, C. et al. Involvement of growth factor receptors in the mammalian UVC response. Cell 78, 963–972 (1994).
    Article CAS Google Scholar
  26. Daub, H., Weiss, F. U., Wallasch, C. & Ullrich, A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 369, 557–560 (1996).
    Article ADS Google Scholar
  27. Honegger, A. M. et al. Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell 51, 199–209 (1987).
    Article CAS Google Scholar
  28. Okabayashi, Y. et al. Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells. J. Biol. Chem. 269, 18674–18678 (1994).
    CAS Google Scholar
  29. Meunier-Durmort, C., Ferry, N., Hainque, B., Delattre, J. & Forest, C. Efficient transfer of regulated genes in adipocytes and hepatoma cells by the combination of liposomes and replication-deficient adenovirus. Eur. J. Biochem. 237, 660–667 (1996).
    Article CAS Google Scholar
  30. Tanaka, T. et al. Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain. J. Biol. Chem. 269, 24020–24026 (1994).
    CAS Google Scholar

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