A P2X purinoceptor expressed by a subset of sensory neurons (original) (raw)
- Letter
- Published: 05 October 1995
- Armen N. Akopian1,
- Lucia Sivilottit2,
- David Colquhoun2,
- Geoffrey Burnstock1 &
- …
- John N. Wood1
Nature volume 377, pages 428–431 (1995)Cite this article
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Abstract
ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation when released from damaged tissue1-10. Here we report the molecular cloning and characterization of a new member of the P2X receptor family3,11,12, P2X3, expressed by these cells. The channel transcript was present in a subset of rat dorsal-root-ganglion sensory neurons, some of which express nociceptor-associated markers; it was absent in other tissues that were tested, including sympathetic, enteric and central nervous system neurons. Moreover, when expressed in Xenopus oocytes, the channel showed an ATP-dependent cation flux. P2X3 is the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons. The remarkable selectivity of expression of the channel coupled with its sensory neuron-like pharmacology suggests that this channel may transduce ATP-evoked nociceptor activation.
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Authors and Affiliations
- Departments of Anatomy and Developmental Biology, University College, London, WC1E 6BT, UK
Chih-Cheng Chen, Armen N. Akopian, Geoffrey Burnstock & John N. Wood - Department of Pharmacology, University College, London, WC1E 6BT, UK
Lucia Sivilottit & David Colquhoun
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- Chih-Cheng Chen
You can also search for this author inPubMed Google Scholar - Armen N. Akopian
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You can also search for this author inPubMed Google Scholar - David Colquhoun
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Chen, CC., Akopian, A., Sivilottit, L. et al. A P2X purinoceptor expressed by a subset of sensory neurons.Nature 377, 428–431 (1995). https://doi.org/10.1038/377428a0
- Received: 02 June 1995
- Accepted: 20 July 1995
- Issue Date: 05 October 1995
- DOI: https://doi.org/10.1038/377428a0
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