Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease (original) (raw)

References

  1. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. & Coffman, R. L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348–2357 (1986).
    CAS PubMed Google Scholar
  2. Mosmann, T. R. & Sad, S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17, 138–146 (1996).
    Article CAS Google Scholar
  3. Abbas, A. K., Murphy, K. M. & Sher, A. Functional diversity of helper T lymphocytes. Nature 383, 787–793 (1996).
    Article ADS CAS Google Scholar
  4. Sher, A. & Coffman, R. L. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10, 385–409 (1992).
    Article CAS Google Scholar
  5. Liblau, R. S., Singer, S. M. & McDevitt, H. O. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16, 34–38 (1995).
    Article CAS Google Scholar
  6. Syrbe, U., Siveke, J. & Hamann, A. Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression? Springer Semin. Immunopathol. 21, 263–285 (1999).
    Article CAS Google Scholar
  7. Kuchroo, V. K. et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80, 707–718 (1995).
    Article CAS Google Scholar
  8. Nicholson, L. B., Greer, J. M., Sobel, R. A., Lees, M. B. & Kuchroo, V. K. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3, 397–405 (1995).
    Article CAS Google Scholar
  9. Lack, G. et al. Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airways function in a murine model of allergen sensitization. J. Immunol. 152, 2546–2554 (1994).
    CAS PubMed Google Scholar
  10. Hofstra, C. L. et al. Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels. J. Immunol. 161, 5054–5060 (1998).
    CAS PubMed Google Scholar
  11. Loetscher, P. et al. CCR5 is characteristic of Th1 lymphocytes. Nature 391, 344–345 (1998).
    Article ADS CAS Google Scholar
  12. Bonecchi, R. et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 187, 129–134 (1998).
    Article CAS Google Scholar
  13. Sallusto, F., Lenig, D., Mackay, C. R. & Lanzavecchia, A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187, 875–883 (1998).
    Article CAS Google Scholar
  14. Venkataraman, C., Schaefer, G. & Schindler, U. Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes. J. Immunol. 165, 632–636 (2000).
    Article CAS Google Scholar
  15. Jourdan, P. et al. IL-4 induces functional cell-surface expression of CXCR4 on human T cells. J. Immunol. 160, 4153–4157 (1998).
    CAS PubMed Google Scholar
  16. Zingoni, A. et al. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J. Immunol. 161, 547–551 (1998).
    CAS PubMed Google Scholar
  17. McAdam, A. J. et al. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J. Immunol. 165, 5035–5040 (2000).
    Article CAS Google Scholar
  18. Lohning, M. et al. T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc. Natl Acad. Sci. USA 95, 6930–6935 (1998).
    Article ADS CAS Google Scholar
  19. Waldner, H., Whitters, M. J., Sobel, R. A., Collins, M. & Kuchroo, V. K. Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor. Proc. Natl Acad. Sci. USA 97, 3412–3417 (2000).
    Article ADS CAS Google Scholar
  20. Seed, B. & Aruffo, A. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc. Natl Acad. Sci. USA 84, 3365–3369 (1987).
    Article ADS CAS Google Scholar
  21. Gordon, E. J., Myers, K. J., Dougherty, J. P., Rosen, H. & Ron, Y. Both anti-CD11a (LFA-1) and anti-CD11b (MAC-1) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 62, 153–160 (1995).
    Article CAS Google Scholar
  22. Tran, E. H., Hoekstra, K., van Rooijen, N., Dijkstra, C. D. & Owens, T. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J. Immunol. 161, 3767–3775 (1998).
    CAS PubMed Google Scholar
  23. McIntire, J. J. et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nature Immunol. 2, 1019–1116 (2001).
    Article Google Scholar
  24. Kohler, G. & Milstein, C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495–497 (1975).
    Article ADS CAS Google Scholar

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