p53 and p73: seeing double? (original) (raw)

Nature Genetics volume 26, pages 391–392 (2000)Cite this article

Whereas p73 is closely related to the tumour-suppressor protein p53, its contribution to tumour suppression and the spatial and temporal regulation of its isoforms is unclear. It has now been established that p73 is a transcriptional target of E2F1. Its ability to induce apoptosis in TP53 −/− cells indicates a tumour-control mechanism that runs parallel to but independent of that mediated by p53. The new results illustrate a complex cross-talk between p53, E2F1 and p73.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA
    María S Soengas & Scott W Lowe

Authors

  1. María S Soengas
  2. Scott W Lowe

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Soengas, M., Lowe, S. p53 and p73: seeing double?.Nat Genet 26, 391–392 (2000). https://doi.org/10.1038/82497

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