OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway (original) (raw)

• Pamer, E. & Cresswell, P. Mechanisms of MHC class-I restricted antigen processing. Annu. Rev. Immunol. 16, 323–358 (1998).
  Article CAS Google Scholar
• Watts, C. Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 15, 821–850 (1997).
  Article CAS Google Scholar
• Heath, W. R. & Carbonne, F. R. Cytotoxic T lymphocyte activation by cross-priming. Curr. Opin. Immunol. 11, 314–318 (1999).
  Article CAS Google Scholar
• Yewdell, J. W., Norbury, C. C. & Bennink J. R. Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccines. Adv. Immunol. 73, 1–77 (1999).
  Article CAS Google Scholar
• Albert, M. L., Sauter, B. & Bhardway, N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392, 86–89 (1998).
  Article CAS Google Scholar
• Rodriguez, A., Regnault, A., Kleijmeer, M., Ricciardi-Castagnoli, P. & Amigorena, S. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells. Nature Cell Biol. 1, 362–368 (1999).
  Article CAS Google Scholar
• Schild, H., Arnold-Schild, D., Lammert, E. & Rammensee, H. G. Stress proteins and immunity mediated by cytotoxic T lymphocytes. Curr. Opin. Immunol. 11, 109–113 (1999).
  Article CAS Google Scholar
• Singh-Jasuja, H. et al. Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis. J. Exp. Med. 191, 1965–1974 (2000).
  Article CAS Google Scholar
• Binder, R. J., Han, D. K. & Srivastava, P. K. CD91: a receptor for heat shock protein gp96. Nature Immunol. 1, 151–155 (2000).
  Article CAS Google Scholar
• Kovacsovics-Bankowski, M. et al. Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc. Natl Acad. Sci. USA 90, 4942–4946 (1993).
  Article CAS Google Scholar
• Norbury, C. C., Hewlett, J. J., Prescott, A. R., Shastri, N. & Watts, C. Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity 3, 783–791 (1995).
  Article CAS Google Scholar
• Kovacsovics-Bankowski, M. & Rock, K. L. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267, 243–246 (1995).
  Article CAS Google Scholar
• Ke, Y. & Kapp, J. A. Exogenous antigens gain access to the major histocompatibility complex class I processing patway in B cells by receptor-mediated uptake. J. Exp. Med. 184, 1179–1184 (1996).
  Article CAS Google Scholar
• Banchereau, J. & Steinman, R. M. Dendritic cells and the control of immunity. Nature 392, 245–252 (1998).
  Article CAS Google Scholar
• Watts, C. Dendritic cells spill the beans. Nature Cell Biol. 1, 152–154 (1999).
  Article Google Scholar
• Timmerman, J. M. & Levy, R. Dendritic cell vaccines for cancer immunotherapy. Annu. Rev. Med. 50, 507–529 (1999).
  Article CAS Google Scholar
• Medzhitov, R. & Janeway, C. A. Innate immunity: impact on the adaptative immune response. Curr. Opin. Immunol. 9, 4–9 (1997).
  Article CAS Google Scholar
• Rescigno, M. et al. Coordinated events during bacteria-induced DC maturation. Immunol. Today 20, 200–203 (1999).
  Article CAS Google Scholar
• Lebecque S. Antigen receptors and dendritic cells. Vaccine 25, 1603–1605 (2000).
  Article Google Scholar
• Muzio, M. et al. Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol. 164, 5998–6004 (2000).
  Article CAS Google Scholar
• Albert, M. L. et al. Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigen to cytotoxic T lymphocytes. J. Exp. Med. 188, 1359–1368 (1998).
  Article CAS Google Scholar
• Bowie, A. & O'Neill, L. A. J. The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J. Leuk. Biol. 67, 508–514 (2000).
  Article CAS Google Scholar
• Muzion, M. & Montovani, A. Toll-like receptors. Microbes Infect. 2, 251–255 (2000).
  Article Google Scholar
• Su, H. R., Morrison, P., Warkins, N. G. & Cadwell, H. D. Identification and characterization of T helper cell epitopes of the major outer membrane protein of Chlamydia trachomatis. J. Exp. Med. 172, 203–206 (1990).
  Article CAS Google Scholar
• Wiertz, E. J. et al. Identification of T cell epitopes occurring in a meningococcal class I outermembrane protein using overlapping peptides assembled with simultaneous multiple peptride synthesis. J. Exp. Med. 176, 79–88 (1992).
  Article CAS Google Scholar
• Poolman, J. T. in Novel Strategies in Design and Production of Vaccines . (eds Cohen, S. & Shafferman, A.) 73–77 (Plenum Press, New York, 1996).
  Book Google Scholar
• Nguyen, T. et al. Chromosomal sequencing using a PCR-based biotin-capture method allowed isolation of the complete gene for the outer membrane protein A of Klebsiella pneumoniae. Gene 27, 93–101 (1998).
  Article Google Scholar
• Haeuw, J. F. et al. The recombinant Klebsiella pneumoniae outer membrane protein OmpA has carrier properties for conjugated antigenic peptides. Eur. J. Biochem. 255, 446–454 (1998).
  Article CAS Google Scholar
• Rauly, I. et al. Carrier properties of a protein derived from the outer membrane protein A of Klebsiella Pneumoniae. Infect. Immun. 67, 5547–5551 (1999).
  CAS PubMed PubMed Central Google Scholar
• Sjolander, A. et al. The serum albumin-binding region of streptococcal protein G: a bacterial fusion partner with carrier-related properties. J. Immunol. Methods 14, 115–123 (1997).
  Article Google Scholar
• Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in TLR4 gene. Science 282, 2085–2088 (1998).
  Article CAS Google Scholar
• Hirshfeld, M. et al. Cutting edge: Inflammatory signaling by Borrelia burgdorfery lipoproteins is mediated by Toll-like receptor 2. J. Immunol. 163, 2382–2386 (1999).
  Google Scholar
• Lanzavecchia, A. Mechanisms of antigen uptake for presentation. Curr. Opin. Immunol. 8, 348–354 (1996).
  Article CAS Google Scholar
• Sanderson, S. & Shastri, N. LacZ inductible, antigen/MHC-specific T cell hybrids. Int. Immunol. 6, 369–376 (1994).
  Article CAS Google Scholar
• Morre, M. W., Carbone, F. R. & Bevan, M. J. Introduction of soluble protein into the class I pathway of antigen, processing and presentation. Cell 54, 777–785 (1988).
  Article Google Scholar
• Coulie, P. G. et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 180, 35–42 (1994).
  Article CAS Google Scholar
• Kawakami, Y. et al. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. Natl Acad. Sci. USA 91, 3515–3519 (1994).
  Article CAS Google Scholar
• Bloom, M. B. et al. Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J. Exp. Med. 185, 453–459 (1997).
  Article CAS Google Scholar
• Valmori, D. et al. Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues. J. Immunol. 160, 1750–1758 (1998).
  CAS PubMed Google Scholar
• Men, Y. et al. Assessment of immunogenicity of human Melan-A peptide analogues in HLA-A*0201/Kb transgenic mice. J. Immunol. 162, 3566–3573 (1999).
  CAS PubMed Google Scholar
• Vitiello, A., Marchesini, D., Furze, J., Sherman, L. A. & Chesnut, R.W. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex. J. Exp. Med. 173, 1007–1015 (1991).
  Article CAS Google Scholar
• Rock, K. L. & Clark, K. Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class I presentation pathway. J. Immunol. 156, 3721–3726 (1996).
  CAS PubMed Google Scholar
• Sigal, L. J., Reiser, H. & Rock, K. L. The role of B7–1 and B7-2 costimulation for the generation of CTL responses in vivo. J. Immunol. 161, 2740–2745 (1998).
  CAS PubMed Google Scholar
• Ridge, J. P., Di Rosa, F. & Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-Killer cell. Nature 393, 474–483 (1998).
  Article CAS Google Scholar
• Storkus, W. J. Reversal of natural killing susceptibility in target cells expressing transfected calls I HLA genes. Proc. Natl Acad. Sci. USA 86, 2361–2364 (1989).
  Article CAS Google Scholar
• Zhou, F., Rouse, B. T. & Huang, L. Prolonged survival of thymoma-bearing mice after vaccination with a soluble protein antigen entrapped in liposomes: a model study. Cancer Res. 52, 6287–6291 (1992).
  CAS PubMed Google Scholar
• Sousa, C. R. & Germain, R. N. Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue. J. Immunol. 162, 6552–6561 (1999).
  Google Scholar
• Soulas, C. et al. Outer membrane protein A (OmpA) binds to and activates human macrophages. J. Immunol. 165, 2335–2340 (2000).
  Article CAS Google Scholar
• Underhill D. M. et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens Nature 401, 811–815 (1999).
  Article CAS Google Scholar
• Freundenberg, M. A. & Galanos, C. Tumor necrosis factor a mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine-treated mice. Infect. Immun. 59, 2110–2115 (1991).
  Google Scholar
• Seon-Kyeong, K. et al. Induction of HLA class I-restricted CD8+ CTLs specific for the major outer membrane protein of Chlamydia trachomatis in human genital tract infections. J. Immunol. 162, 6855–6866 (1999).
  Google Scholar
• Gromme, M. et al. Recycling MHC class I molecules and endosomal peptide loading. Proc. Natl Acad. Sci. USA 96, 10326–10331 (1999).
  Article CAS Google Scholar
• Wiedlocha, A. Novel protein toxin-based strategy for development of cytotoxic T lymphocyte vaccines. Arch. Immunol. Ther. Exp. 46, 341–346 (1998).
  CAS Google Scholar