Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci (original) (raw)
- Brief Communication
- Published: April 2001
- Baljinder Ubhi1,
- Robert Lawrence1,
- Gonçalo R. Abecasis1,
- Andrew J. Walley1,
- Helen E. Cox2,
- Rosemary Coleman2,
- Nicholas I. Leaves1,
- Richard C. Trembath3,
- Miriam F. Moffatt1 &
- …
- John I. Harper2
Nature Genetics volume 27, pages 372–373 (2001)Cite this article
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Abstract
We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.
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Acknowledgements
We thank J.A. Faux for IgE estimations and L.R. Cardon for helpful comments on the linkage analyses. This study was funded by the Wellcome Trust.
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Authors and Affiliations
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
William O.C.M. Cookson, Baljinder Ubhi, Robert Lawrence, Gonçalo R. Abecasis, Andrew J. Walley, Nicholas I. Leaves & Miriam F. Moffatt - Great Ormond Street Hospital and the Institute for Child Health, London, UK
Helen E. Cox, Rosemary Coleman & John I. Harper - Department of Genetics, University of Leicester, Leicester, UK
Richard C. Trembath
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- William O.C.M. Cookson
You can also search for this author inPubMed Google Scholar - Baljinder Ubhi
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Correspondence toWilliam O.C.M. Cookson.
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Cookson, W., Ubhi, B., Lawrence, R. et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.Nat Genet 27, 372–373 (2001). https://doi.org/10.1038/86867
- Received: 26 January 2001
- Accepted: 05 March 2001
- Issue Date: April 2001
- DOI: https://doi.org/10.1038/86867
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