Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci (original) (raw)

Nature Genetics volume 27, pages 372–373 (2001)Cite this article

Abstract

We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.

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References

  1. Larsen, F.S., Holm, N.V. & Henningsen, K. J. Am. Acad. Dermatol. 15, 487–494 (1986).
    Article CAS Google Scholar
  2. Schultz Larsen, F. J. Am. Acad. Dermatol. 28, 719–723 (1993).
    Article CAS Google Scholar
  3. Juhlin, L., Johansson, G., Bennich, H., Hogman, C. & Thyresson, N. Arch. Dermatol. 100, 12–16 (1969).
    Article CAS Google Scholar
  4. Bos, J. Immunology of Atopic Dermatitis 178–185 (Blackwell Science, Oxford, 2000).
    Google Scholar
  5. Lee, Y.A. et al. Nature Genet. 26, 470–473 (2000).
    Article CAS Google Scholar
  6. Becker, K. et al. Proc. Natl. Acad. Sci. USA 95, 9979–9984 (1998).
    Article CAS Google Scholar
  7. Cookson, W. Nature 402, B5–11 (1999).
    Article CAS Google Scholar
  8. Capon, F. et al. J. Invest. Dermatol. 112, 32–35 (1999).
    Article CAS Google Scholar
  9. Tomfohrde, J. et al. Science 264, 1141–1145 (1994).
    Article CAS Google Scholar
  10. Trembath, R. et al. Hum. Mol. Genet. 6, 813–820 (1997).
    Article CAS Google Scholar
  11. Enlund, F. et al. Eur. J. Hum. Genet. 7, 783–790 (1999).
    Article CAS Google Scholar
  12. Matthews, D. et al. Nature Genet. 14, 231–233 (1996).
    Article CAS Google Scholar
  13. Nair, R. et al. Hum. Mol. Genet. 6, 1349–1356 (1997).
    Article CAS Google Scholar
  14. Enlund, F. et al. Hum. Hered. 49, 2–8 (1999).
    Article CAS Google Scholar
  15. Hardas, B. et al. J. Invest. Dermatol. 106, 753–758 (1996).
    Article CAS Google Scholar

Download references

Acknowledgements

We thank J.A. Faux for IgE estimations and L.R. Cardon for helpful comments on the linkage analyses. This study was funded by the Wellcome Trust.

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Authors and Affiliations

  1. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    William O.C.M. Cookson, Baljinder Ubhi, Robert Lawrence, Gonçalo R. Abecasis, Andrew J. Walley, Nicholas I. Leaves & Miriam F. Moffatt
  2. Great Ormond Street Hospital and the Institute for Child Health, London, UK
    Helen E. Cox, Rosemary Coleman & John I. Harper
  3. Department of Genetics, University of Leicester, Leicester, UK
    Richard C. Trembath

Authors

  1. William O.C.M. Cookson
  2. Baljinder Ubhi
  3. Robert Lawrence
  4. Gonçalo R. Abecasis
  5. Andrew J. Walley
  6. Helen E. Cox
  7. Rosemary Coleman
  8. Nicholas I. Leaves
  9. Richard C. Trembath
  10. Miriam F. Moffatt
  11. John I. Harper

Corresponding author

Correspondence toWilliam O.C.M. Cookson.

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Cookson, W., Ubhi, B., Lawrence, R. et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.Nat Genet 27, 372–373 (2001). https://doi.org/10.1038/86867

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