Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci (original) (raw)

Nature Genetics volume 27, pages 372–373 (2001)Cite this article

Abstract

We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.

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Acknowledgements

We thank J.A. Faux for IgE estimations and L.R. Cardon for helpful comments on the linkage analyses. This study was funded by the Wellcome Trust.

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Authors and Affiliations

  1. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    William O.C.M. Cookson, Baljinder Ubhi, Robert Lawrence, Gonçalo R. Abecasis, Andrew J. Walley, Nicholas I. Leaves & Miriam F. Moffatt
  2. Great Ormond Street Hospital and the Institute for Child Health, London, UK
    Helen E. Cox, Rosemary Coleman & John I. Harper
  3. Department of Genetics, University of Leicester, Leicester, UK
    Richard C. Trembath

Authors

  1. William O.C.M. Cookson
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  2. Baljinder Ubhi
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  3. Robert Lawrence
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  4. Gonçalo R. Abecasis
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  5. Andrew J. Walley
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  6. Helen E. Cox
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  7. Rosemary Coleman
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  8. Nicholas I. Leaves
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  9. Richard C. Trembath
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  10. Miriam F. Moffatt
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  11. John I. Harper
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Corresponding author

Correspondence toWilliam O.C.M. Cookson.

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Cookson, W., Ubhi, B., Lawrence, R. et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.Nat Genet 27, 372–373 (2001). https://doi.org/10.1038/86867

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