Tumour-necrosis factor from the rabbit. II. Production by monocytes (original) (raw)

Abstract

Mononuclear cells from normal rabbit blood were cytotoxic to a number of cell lines in vitro. The cytotoxic cells were contained in the monocyte-enriched fraction adherent to plastic. Supernatants of the monocyte-enriched fraction had the same cytotoxic specificity as the parent cells. The cytotoxic factor precipitated in 50% saturated ammonium sulphate solution and on gel filtration was heterogeneous with a mol.-wt. range of 30--50,000 u. On the basis of specificity and molecular characteristics, this cytotoxic factor closely resembles rabbit tumour-necrosis factor (TNF) suggesting that TNF or a closely related factor is a normal product of mononuclear phagocytes.

Access through your institution

Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Subscribe to this journal

Receive 24 print issues and online access

$259.00 per year

only $10.79 per issue

Learn more

Buy this article

• Purchase on SpringerLink
• Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

• Log in
• Learn about institutional subscriptions
• Read our FAQs
• Contact customer support

Similar content being viewed by others

Umbilical cord blood transplants facilitated by the French cord blood banks network. On behalf of the Agency of Biomedicine, Eurocord and the French society of bone marrow transplant and cell therapy (SFGM-TC)

Article 14 May 2021

In depth transcriptomic profiling defines a landscape of dysfunctional immune responses in patients with VEXAS syndrome

Article Open access 20 May 2025

Single-cell profiling of peripheral blood mononuclear cells from patients treated with oncolytic adenovirus TILT-123 reveals baseline immune status as a predictor of therapy outcomes

Article Open access 10 April 2025

Authors

1. N Matthews
   View author publications
   Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matthews, N. Tumour-necrosis factor from the rabbit. II. Production by monocytes.Br J Cancer 38, 310–315 (1978). https://doi.org/10.1038/bjc.1978.203

Download citation

• Issue date: 01 August 1978
• DOI: https://doi.org/10.1038/bjc.1978.203

This article is cited by

• Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα

  • Roozbeh Aschar-Sobbi
  • Farzad Izaddoustdar
  • Peter H. Backx
    Nature Communications (2015)

• Biology of TNFα and IL-10, and their imbalance in heart failure

  • Kuljeet Kaur
  • Sanjiv Dhingra
  • Pawan K. Singal
    Heart Failure Reviews (2009)

• Selective inhibition of TNF-α-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib

  • Y Ueno
  • H Sakurai
  • I Saiki
    British Journal of Cancer (2005)

• Structure of tumor necrosis factor and its receptor

  • Bharat B. Aggarwal
    Biotherapy (1991)

• Absence of tumor necrosis factor-? in suction blister fluids and stratum corneum from patients with psoriasis

  • H. Takematsu
  • H. Ohta
  • H. Tagami
    Archives of Dermatological Research (1989)