Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy (original) (raw)

• Gaynon PS, Carrel AL . Glucocorticosteroid therapy in childhood acute lymphoblastic leukemia. Adv Exp Med Biol 1999; 457: 593–605.
  Article CAS Google Scholar
• Greenstein S, Ghias K, Krett NL, Rosen ST . Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies. Clin Cancer Res 2002; 8: 1681–1694.
  CAS PubMed Google Scholar
• Kaspers GJ, Pieters R, Van Zantwijk CH, Van Wering ER, Van Der Does-Van Den Berg A, Veerman AJ . Prednisolone resistance in childhood acute lymphoblastic leukemia: vitro-vivo correlations and cross-resistance to other drugs. Blood 1998; 92: 259–266.
  CAS PubMed Google Scholar
• Schrappe M, Reiter A, Zimmermann M, Harbott J, Ludwig WD, Henze G et al. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Munster. Leukemia 2000; 14: 2205–2222.
  Article CAS Google Scholar
• Distelhorst CW . Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ 2002; 9: 6–19.
  Article CAS Google Scholar
• Gozuacik D, Kimchi A . Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23: 2891–2906.
  Article CAS Google Scholar
• Jaattela M . Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene 2004; 23: 2746–2756.
  Article Google Scholar
• Gozuacik D, Kimchi A . Autophagy and cell death. Curr Top Dev Biol 2007; 78: 217–245.
  Article CAS Google Scholar
• Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999; 59: 59–65.
  Article CAS Google Scholar
• Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P . Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000; 275: 992–998.
  Article CAS Google Scholar
• Botti J, Djavaheri-Mergny M, Pilatte Y, Codogno P . Autophagy signaling and the cogwheels of cancer. Autophagy 2006; 2: 67–73.
  Article CAS Google Scholar
• Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP . Identification of a tumour suppressor network opposing nuclear Akt function. Nature 2006; 441: 523–527.
  Article CAS Google Scholar
• Bernardi R, Pandolfi PP . Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene 2003; 22: 9048–9057.
  Article CAS Google Scholar
• Wang ZG, Delva L, Gaboli M, Rivi R, Giorgio M, Cordon-Cardo C et al. Role of PML in cell growth and the retinoic acid pathway. Science 1998; 279: 1547–1551.
  Article CAS Google Scholar
• Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R et al. PML is essential for multiple apoptotic pathways. Nat Genet 1998; 20: 266–272.
  Article CAS Google Scholar
• Quignon F, De Bels F, Koken M, Feunteun J, Ameisen JC, de The H . PML induces a novel caspase-independent death process. Nat Genet 1998; 20: 259–265.
  Article CAS Google Scholar
• Laane E, Panaretakis T, Pokrovskaja K, Buentke E, Corcoran M, Soderhall S et al. Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members. Haematologica 2007; 92: 1460–1469.
  Article CAS Google Scholar
• Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19: 5720–5728.
  Article CAS Google Scholar
• Mizushima N, Yoshimori T . How to interpret LC3 immunoblotting. Autophagy 2007; 3: 542–545.
  Article CAS Google Scholar
• Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4: 151–175.
  Article CAS Google Scholar
• Fass E, Shvets E, Degani I, Hirschberg K, Elazar Z . Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J Biol Chem 2006; 281: 36303–36316.
  Article CAS Google Scholar
• Iwai-Kanai E, Yuan H, Huang C, Sayen MR, Perry-Garza CN, Kim L et al. A method to measure cardiac autophagic flux in vivo. Autophagy 2008; 4: 322–329.
  Article CAS Google Scholar
• Bellosillo B, Villamor N, Lopez-Guillermo A, Marce S, Bosch F, Campo E et al. Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia. Blood 2002; 100: 1810–1816.
  Article CAS Google Scholar
• Blommaart EF, Krause U, Schellens JP, Vreeling-Sindelarova H, Meijer AJ . The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 1997; 243: 240–246.
  Article CAS Google Scholar
• Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402: 672–676.
  Article CAS Google Scholar
• Maiuri MC, Zalckvar E, Kimchi A, Kroemer G . Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007; 8: 741–752.
  Article CAS Google Scholar
• Klionsky DJ, Emr SD . Autophagy as a regulated pathway of cellular degradation. Science 2000; 290: 1717–1721.
  Article CAS Google Scholar
• Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996; 15: 6541–6551.
  Article CAS Google Scholar
• Soderberg O, Gullberg M, Jarvius M, Ridderstrale K, Leuchowius KJ, Jarvius J et al. Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods 2006; 3: 995–1000.
  Article Google Scholar
• Kondo Y, Kanzawa T, Sawaya R, Kondo S . The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5: 726–734.
  Article CAS Google Scholar
• Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol 2006; 8: 1124–1132.
  Article CAS Google Scholar
• Rusten TE, Lindmo K, Juhasz G, Sass M, Seglen PO, Brech A et al. Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell 2004; 7: 179–192.
  Article CAS Google Scholar
• Swerdlow S, McColl K, Rong Y, Lam M, Gupta A, Distelhorst CW . Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes. Autophagy 2008; 4: 1–9.
  Article Google Scholar
• Saeki K, Yuo A, Okuma E, Yazaki Y, Susin SA, Kroemer G et al. Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells. Cell Death Differ 2000; 7: 1263–1269.
  Article CAS Google Scholar
• Chrysis D, Zaman F, Chagin AS, Takigawa M, Savendahl L . Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3′-kinase signaling pathway. Endocrinology 2005; 146: 1391–1397.
  Article CAS Google Scholar
• Gustafsson G, Schmiegelow K, Forestier E, Clausen N, Glomstein A, Jonmundsson G et al. Improving outcome through two decades in childhood ALL in the Nordic countries: the impact of high-dose methotrexate in the reduction of CNS irradiation. Nordic Society of Pediatric Haematology and Oncology (NOPHO). Leukemia 2000; 14: 2267–2275.
  Article CAS Google Scholar
• Schmiegelow K, Gustafsson G . Acute Lymphoblastic leukemia In: PA V (ed). Cancer in Chidlren. Clinical Management. Fifth Edition. Oxford University Press: Oxford, 2005.
  Google Scholar
• Jaffe ES, Harris NL, Stein H, Vardiman JW (eds.). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. IARC Press: Lyon, 2001.
  Google Scholar
• Panaretakis T, Pokrovskaja K, Shoshan MC, Grander D . Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin. J Biol Chem 2002; 277: 44317–44326.
  Article CAS Google Scholar
• Thyrell L, Erickson S, Zhivotovsky B, Pokrovskaja K, Sangfelt O, Castro J et al. Mechanisms of Interferon-alpha induced apoptosis in malignant cells. Oncogene 2002; 21: 1251–1262.
  Article CAS Google Scholar
• Hansson A, Hance N, Dufour E, Rantanen A, Hultenby K, Clayton DA et al. A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. Proc Natl Acad Sci USA 2004; 101: 3136–3141.
  Article CAS Google Scholar