Different forms of cell death induced by putative BCL2 inhibitors (original) (raw)

• Hanahan D, Weinberg RA . The hallmarks of cancer. Cell 2000; 100: 57–70.
  Article CAS Google Scholar
• Arends MJ, Wyllie AH . Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 1991; 32: 223–254.
  Article CAS Google Scholar
• Jaattela M . Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene 2004; 23: 2746–2756.
  Article Google Scholar
• Green DR, Kroemer G . The pathophysiology of mitochondrial cell death. Science 2004; 305: 626–629.
  Article CAS Google Scholar
• Cohen GM . Caspases: the executioners of apoptosis. Biochem J 1997; 326: 1–16.
  Article CAS Google Scholar
• Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001; 292: 727–730.
  Article CAS Google Scholar
• Adams JM, Cory S . The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007; 26: 1324–1337.
  Article CAS Google Scholar
• Amundson SA, Myers TG, Scudiero D, Kitada S, Reed JC, Fornace Jr AJ . An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 2000; 60: 6101–6110.
  CAS PubMed Google Scholar
• Vogler M, Dinsdale D, Dyer MJ, Cohen GM . Bcl-2 inhibitors: small molecules with a big impact on cancer therapy. Cell Death Differ 2009; 16: 360–367.
  Article CAS Google Scholar
• Zeitlin BD, Zeitlin IJ, Nor JE . Expanding circle of inhibition: small-molecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents. J Clin Oncol 2008; 26: 4180–4188.
  Article CAS Google Scholar
• Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435: 677–681.
  Article CAS Google Scholar
• Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A et al. Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem 2007; 50: 641–662.
  Article CAS Google Scholar
• Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A . Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 2007; 117: 112–121.
  Article CAS Google Scholar
• Tahir SK, Yang X, Anderson MG, Morgan-Lappe SE, Sarthy AV, Chen J et al. Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737. Cancer Res 2007; 67: 1176–1183.
  Article CAS Google Scholar
• van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 2006; 10: 389–399.
  Article CAS Google Scholar
• Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci USA 2007; 104: 19512–19517.
  Article CAS Google Scholar
• Kitada S, Leone M, Sareth S, Zhai D, Reed JC, Pellecchia M . Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem 2003; 46: 4259–4264.
  Article CAS Google Scholar
• Becattini B, Kitada S, Leone M, Monosov E, Chandler S, Zhai D et al. Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). Chem Biol 2004; 11: 389–395.
  Article CAS Google Scholar
• Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H et al. Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem 2003; 278: 20453–20456.
  Article CAS Google Scholar
• Milanesi E, Costantini P, Gambalunga A, Colonna R, Petronilli V, Cabrelle A et al. The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative. J Biol Chem 2006; 281: 10066–10072.
  Article CAS Google Scholar
• Kitada S, Kress CL, Krajewska M, Jia L, Pellecchia M, Reed JC . Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood 2008; 111: 3211–3219.
  Article CAS Google Scholar
• Herbert JM, Augereau JM, Gleye J, Maffrand JP . Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 1990; 172: 993–999.
  Article CAS Google Scholar
• Wilson WH, Tulipe A, Levine AM, Dunleavy K, Krivoshik AP, Hagey AE et al. A phase 1/2a study evaluating the safety, pharmacokinetics and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies. Blood 2007; 110 Abstract 1371.
• Mohammad R, Giri A, Goustin AS . Small-molecule inhibitors of Bcl-2 family proteins as therapeutic agents in cancer. Recent Patents Anticancer Drug Discov 2008; 3: 20–30.
  Article CAS Google Scholar
• O'Brien SM, Claxton DF, Crump M, Faderl S, Kipps T, Keating MJ et al. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood 2009; 113: 299–305.
  Article CAS Google Scholar
• Samraj AK, Keil E, Ueffing N, Schulze-Osthoff K, Schmitz I . Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis. J Biol Chem 2006; 281: 29652–29659.
  Article CAS Google Scholar
• Samraj AK, Sohn D, Schulze-Osthoff K, Schmitz I . Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell 2007; 18: 84–93.
  Article CAS Google Scholar
• Inoue S, Riley J, Gant TW, Dyer MJ, Cohen GM . Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa. Leukemia 2007; 21: 1773–1782.
  Article CAS Google Scholar
• Brown DG, Sun XM, Cohen GM . Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J Biol Chem 1993; 268: 3037–3039.
  CAS PubMed Google Scholar
• Vogler M, Dinsdale D, Sun XM, Young KW, Butterworth M, Nicotera P et al. A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells. Cell Death Differ 2008; 15: 820–830.
  Article CAS Google Scholar
• Willis SN, Adams JM . Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 2005; 17: 617–625.
  Article CAS Google Scholar
• Konopleva M, Watt J, Contractor R, Tsao T, Harris D, Estrov Z et al. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax). Cancer Res 2008; 68: 3413–3420.
  Article CAS Google Scholar
• Wan KF, Chan SL, Sukumaran SK, Lee MC, Yu VC . Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism. J Biol Chem 2008; 283: 8423–8433.
  Article CAS Google Scholar
• Tsujimoto Y . Bcl-2 family of proteins: life-or-death switch in mitochondria. Biosci Rep 2002; 22: 47–58.
  Article CAS Google Scholar
• White C, Li C, Yang J, Petrenko NB, Madesh M, Thompson CB et al. The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nat Cell Biol 2005; 7: 1021–1028.
  Article CAS Google Scholar
• Balakrishnan K, Wierda WG, Keating MJ, Gandhi V . Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2008; 112: 1971–1980.
  Article CAS Google Scholar
• Zhang M, Liu H, Tian Z, Griffith BN, Ji M, Li QQ . Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways. Life Sci 2007; 80: 767–774.
  Article CAS Google Scholar
• Oliver L, Mahe B, Gree R, Vallette FM, Juin P . HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells. Leuk Res 2007; 31: 859–863.
  Article CAS Google Scholar
• Chen J, Freeman A, Liu J, Dai Q, Lee RM . The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195. Mol Cancer Ther 2002; 1: 961–967.
  PubMed Google Scholar
• Campas C, Cosialls AM, Barragan M, Iglesias-Serret D, Santidrian AF, Coll-Mulet L et al. Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Exp Hematol 2006; 34: 1663–1669.
  Article CAS Google Scholar
• John GB, Shang Y, Li L, Renken C, Mannella CA, Selker JM et al. The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell 2005; 16: 1543–1554.
  Article CAS Google Scholar
• Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P . Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 1997; 185: 1481–1486.
  Article CAS Google Scholar
• Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S et al. Programmed anuclear cell death delimits platelet life span. Cell 2007; 128: 1173–1186.
  Article CAS Google Scholar
• Ko CH, Shen SC, Yang LY, Lin CW, Chen YC . Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. Int J Cancer 2007; 121: 1670–1679.
  Article CAS Google Scholar
• Trudel S, Li ZH, Rauw J, Tiedemann RE, Wen XY, Stewart AK . Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood 2007; 109: 5430–5438.
  Article CAS Google Scholar
• Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR, Cohen GM . Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem 1999; 274: 5053–5060.
  Article CAS Google Scholar