Regulation of c-Myc protein stability by proteasome activator REGγ (original) (raw)

• Adams J . The proteasome: structure, function, and role in the cell. Cancer Treat Rev 2003; 29 (Suppl 1): 3–9.
  Article CAS Google Scholar
• Moreau P, Richardson PG, Cavo M, Orlowski RZ, San Miguel JF, Palumbo A et al. Proteasome inhibitors in multiple myeloma: 10 years later. Blood 2012; 120: 947–959.
  Article CAS Google Scholar
• Voges D, Zwickl P, Baumeister W . The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 1999; 68: 1015–1068.
  Article CAS Google Scholar
• Baumeister W, Walz J, Zuhl F, Seemuller E . The proteasome: paradigm of a self-compartmentalizing protease. Cell 1998; 92: 367–380.
  Article CAS Google Scholar
• Rechsteiner M, Realini C, Ustrell V . The proteasome activator 11 S REG (PA28) and class I antigen presentation. Biochem J 2000; 345 (Part 1): 1–15.
  Article CAS Google Scholar
• Mao I, Liu J, Li X, Luo H . REGgamma, a proteasome activator and beyond? Cell Mol Life Sci 2008; 65: 3971–3980.
  Article CAS Google Scholar
• Li X, Lonard DM, Jung SY, Malovannaya A, Feng Q, Qin J et al. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell 2006; 124: 381–392.
  Article CAS Google Scholar
• Chen X, Barton LF, Chi Y, Clurman BE, Roberts JM . Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome. Mol Cell 2007; 26: 843–852.
  Article CAS Google Scholar
• Ying H, Furuya F, Zhao L, Araki O, West BL, Hanover JA et al. Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression. J Clin Invest 2006; 116: 2972–2984.
  Article CAS Google Scholar
• Zhang Z, Zhang R . Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation. EMBO J 2008; 27: 852–864.
  Article CAS Google Scholar
• Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P et al. The REGgamma proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metab 2013; 18: 380–391.
  Article CAS Google Scholar
• Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y et al. PKA turnover by the REGgamma-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. J Mol Cell Cardiol 2014; 72C: 28–38.
  Article Google Scholar
• Masson P, Lundgren J, Young P . Drosophila proteasome regulator REGgamma: transcriptional activation by DNA replication-related factor DREF and evidence for a role in cell cycle progression. J Mol Biol 2003; 327: 1001–1012.
  Article CAS Google Scholar
• Adhikary S, Eilers M . Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 2005; 6: 635–645.
  Article CAS Google Scholar
• van Riggelen J, Yetil A, Felsher DW . MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer 2010; 10: 301–309.
  Article CAS Google Scholar
• Eilers M, Eisenman RN . Myc’s broad reach. Genes Dev 2008; 22: 2755–2766.
  Article CAS Google Scholar
• Dang CV . MYC on the path to cancer. Cell 2012; 149: 22–35.
  Article CAS Google Scholar
• Nesbit CE, Tersak JM, Prochownik EV . MYC oncogenes and human neoplastic disease. Oncogene 1999; 18: 3004–3016.
  Article CAS Google Scholar
• Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci USA 2004; 101: 9085–9090.
  Article CAS Google Scholar
• Thomas LR, Tansey WP . Proteolytic control of the oncoprotein transcription factor Myc. Adv Cancer Res 2011; 110: 77–106.
  Article CAS Google Scholar
• Salghetti SE, Kim SY, Tansey WP . Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J 1999; 18: 717–726.
  Article CAS Google Scholar
• Adhikary S, Marinoni F, Hock A, Hulleman E, Popov N, Beier R et al. The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell 2005; 123: 409–421.
  Article CAS Google Scholar
• Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H et al. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 2004; 23: 2116–2125.
  Article CAS Google Scholar
• von der Lehr N, Johansson S, Wu S, Bahram F, Castell A, Cetinkaya C et al. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell 2003; 11: 1189–1200.
  Article CAS Google Scholar
• Choi SH, Wright JB, Gerber SA, Cole MD . Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. Genes Dev 2010; 24: 1236–1241.
  Article CAS Google Scholar
• Popov N, Schulein C, Jaenicke LA, Eilers M . Ubiquitylation of the amino terminus of Myc by SCF(beta-TrCP) antagonizes SCF(Fbw7)-mediated turnover. Nat Cell Biol 2010; 12: 973–981.
  Article CAS Google Scholar
• Paul I, Ahmed SF, Bhowmik A, Deb S, Ghosh MK . The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity. Oncogene 2013; 32: 1284–1295.
  Article CAS Google Scholar
• Farrell AS, Sears RC . MYC degradation. Cold Spring Harbor Perspect Med 2014; 4 a014365, 1–15.
  Article Google Scholar
• Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ et al. Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet 2005; 37: 1281–1288.
  Article CAS Google Scholar
• Li X, Amazit L, Long W, Lonard DM, Monaco JJ, O'Malley BW . Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol Cell 2007; 26: 831–842.
  Article Google Scholar
• Zhang Z, Clawson A, Realini C, Jensen CC, Knowlton JR, Hill CP et al. Identification of an activation region in the proteasome activator REGalpha. Proc Natl Acad Sci USA 1998; 95: 2807–2811.
  Article CAS Google Scholar
• Li J, Gao X, Ortega J, Nazif T, Joss L, Bogyo M et al. Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta. EMBO J 2001; 20: 3359–3369.
  Article CAS Google Scholar
• Conacci-Sorrell M, Ngouenet C, Anderson S, Brabletz T, Eisenman RN . Stress-induced cleavage of Myc promotes cancer cell survival. Genes Dev 2014; 28: 689–707.
  Article CAS Google Scholar
• Conacci-Sorrell M, Ngouenet C, Eisenman RN . Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell 2010; 142: 480–493.
  Article CAS Google Scholar
• Liu J, Wang Y, Li L, Zhou L, Wei H, Zhou Q et al. Site-specific acetylation of the proteasome activator REGgamma directs its heptameric structure and functions. J Biol Chem 2013; 288: 16567–16578.
  Article CAS Google Scholar
• Dang CV . c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999; 19: 1–11.
  Article CAS Google Scholar
• Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY et al. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nat Cell Biol 2010; 12: 457–467.
  Article CAS Google Scholar
• Sears R, Ohtani K, Nevins JR . Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol Cell Biol 1997; 17: 5227–5235.
  Article CAS Google Scholar
• Dai MS, Arnold H, Sun XX, Sears R, Lu H . Inhibition of c-Myc activity by ribosomal protein L11. EMBO J 2007; 26: 3332–3345.
  Article CAS Google Scholar
• Gallant P . Myc function in Drosophila. Cold Spring Harbor Perspect Med 2013; 3: a014324.
  Article Google Scholar
• Montero L, Muller N, Gallant P . Induction of apoptosis by Drosophila Myc. Genesis 2008; 46: 104–111.
  Article CAS Google Scholar
• Brand AH, Perrimon N . Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993; 118: 401–415.
  CAS Google Scholar
• Uchimura Y, Barton LF, Rada C, Neuberger MS . REG-gamma associates with and modulates the abundance of nuclear activation-induced deaminase. J Exp Med 2011; 208: 2385–2391.
  Article CAS Google Scholar
• Kanai K, Aramata S, Katakami S, Yasuda K, Kataoka K . Proteasome activator PA28{gamma} stimulates degradation of GSK3-phosphorylated insulin transcription activator MAFA. J Mol Endocrinol 2011; 47: 119–127.
  Article CAS Google Scholar
• Okamura T, Taniguchi S, Ohkura T, Yoshida A, Shimizu H, Sakai M et al. Abnormally high expression of proteasome activator-gamma in thyroid neoplasm. J Clin Endocrinol Metab 2003; 88: 1374–1383.
  Article CAS Google Scholar
• He J, Cui L, Zeng Y, Wang G, Zhou P, Yang Y et al. REGgamma is associated with multiple oncogenic pathways in human cancers. BMC Cancer 2012; 12: 75.
  Article CAS Google Scholar
• Liu N, Li H, Li S, Shen M, Xiao N, Chen Y et al. The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem 2010; 285: 18858–18867.
  Article CAS Google Scholar