Current advances in humanized mouse models (original) (raw)

• Shultz LD, Ishikawa F, Greiner DL . Humanized mice in translational biomedical research. Nat Rev Immunol 2007; 7: 118–130.
  Article CAS PubMed Google Scholar
• Ito M, Kobayashi K, Nakahata T . NOD/Shi-scid IL2rγ null (NOG) mice more appropriate for humanized mouse models. Curr Top Microbiol Immunol 2008; 324: 53–76.
  CAS PubMed Google Scholar
• Legrand N, Weijer K, Spits H . Experimental models to study development and function of the human immune system in vivo. J Immunol 2006; 176: 2053–2058.
  CAS PubMed Google Scholar
• Zhang B, Duan Z, Zhao Y . Mouse models with human immunity and their application in biomedical research. J Cell Mol Med 2009; 13: 1043–1058.
  CAS PubMed Google Scholar
• Issacson J, Cattanach B . Report. Mouse News Lett 1962; 27: 31.
  Google Scholar
• Bosma GC, Custer RP, Bosma MJ . A severe combined immunodeficiency mutation in the mouse. Nature 1983; 301: 527–530.
  CAS PubMed Google Scholar
• Shultz LD, Schweitzer PA, Christianson SW, Gott B, Schweitzer IB, Tennent B et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 1995; 154: 180–191.
  CAS PubMed Google Scholar
• Koyanagi Y, Tanaka Y, Tanaka R, Misawa N, Kawano Y, Tanaka T et al. High levels of viremia in _hu_-PBL-NOD-scid mice with HIV-1 infection. Leukemia 1 1997; Suppl 3, 109–112.
• Christianson SW, Greiner DL, Hesselton RA, Leif JH, Wagar EJ, Schweitzer IB et al. Enhanced human CD4+ T cell engraftment in β2-microglobulin-deficient NOD-scid mice. J Immunol 1997; 158: 3578–3586.
  CAS PubMed Google Scholar
• Shultz LD, Banuelos S, Lyons B, Samuels R, Burzenski L, Gott B et al. NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. Transplantation 2003; 76: 1036–1042.
  PubMed Google Scholar
• Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K et al. NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells. Blood 2002; 100: 3175–3182.
  CAS PubMed Google Scholar
• Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2Rγ null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005; 174: 6477–6489.
  CAS PubMed Google Scholar
• Goldman JP, Blundell MP, Lopes L, Kinnon C, Di Santo JP, Thrasher AJ . Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain. Br J Haematol 1998; 103: 335–342.
  CAS PubMed Google Scholar
• Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 2004; 304: 104–107.
  CAS PubMed Google Scholar
• Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W et al. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1null) interleukin (IL)-2 receptor common gamma chain (IL2rγnull) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol 2008; 154: 270–284.
  CAS PubMed PubMed Central Google Scholar
• Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J et al. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγ null mutation. Clin Immunol 2010; 135: 84–98.
  CAS PubMed PubMed Central Google Scholar
• Yahata T, Ando K, Nakamura Y, Ueyama Y, Shimamura K, Tamaoki N et al. Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor γnull mice. J Immunol 2002; 169: 204–209.
  CAS PubMed Google Scholar
• Hiramatsu H, Nishikomori R, Heike T, Ito M, Kobayashi K, Katamura K et al. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γcnull mice model. Blood 2003; 102: 873–880.
  CAS PubMed Google Scholar
• Ishikawa F, Shimazu H, Shultz LD, Fukata M, Nakamura R, Lyons B et al. Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion. FASEB J 2006; 20: 950–952.
  CAS PubMed Google Scholar
• Willinger T, Rongvaux A, Strowig T, Manz MG, Flavell RA . Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement. Trends Immunol 2011; 32: 321–327.
  CAS PubMed Google Scholar
• Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice. Blood 2005; 106: 1565–1573.
  CAS PubMed PubMed Central Google Scholar
• Lepus CM, Gibson TF, Gerber SA, Kawikova I, Szczepanik M, Hossain J et al. Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice. Hum Immunol 2009; 70: 790–802.
  CAS PubMed PubMed Central Google Scholar
• Matsumura T, Kametani Y, Ando K, Hirano Y, Katano I, Ito R et al. Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/γcnull (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells. Exp Hematol 2003; 31: 789–797.
  PubMed Google Scholar
• Hayakawa J, Hsieh MM, Uchida N, Phang O, Tisdale JF . Busulfan produces efficient human cell engraftment in NOD/LtSz-Scid IL2Rγ null mice. Stem Cells 2009; 27: 175–182.
  CAS PubMed PubMed Central Google Scholar
• Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I et al. The analysis of the functions of human B and T cells in humanized NOD/shi-scid/γcnull (NOG) mice (hu-HSC NOG mice). Int Immunol 2009; 21: 843–858.
  CAS PubMed Google Scholar
• McCune J, Kaneshima H, Krowka J, Namikawa R, Outzen H, Peault B et al. The _SCID_-hu mouse: a small animal model for HIV infection and pathogenesis. Annu Rev Immunol 1991; 9: 399–429.
  CAS PubMed Google Scholar
• McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL . The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 1988; 241: 1632–1639.
  CAS PubMed Google Scholar
• Kirberg J, Berns A, von Boehmer H . Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J Exp Med 1997; 186: 1269–1275.
  CAS PubMed PubMed Central Google Scholar
• Custer RP, Bosma GC, Bosma MJ . Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am J Pathol 1985; 120: 464–477.
  CAS PubMed PubMed Central Google Scholar
• Bosma MJ . B and T cell leakiness in the scid mouse mutant. Immunodefic Rev 1992; 3: 261–276.
  CAS PubMed Google Scholar
• Kato C, Fujii E, Chen YJ, Endaya BB, Matsubara K, Suzuki M et al. Spontaneous thymic lymphomas in the non-obese diabetic/Shi-scid, IL-2Rγ null mouse. Lab Anim 2009; 43: 402–404.
  CAS PubMed Google Scholar
• Katano I, Ito R, Eto T, Aiso S, Ito M . Immunodeficient NOD-scid IL-2Rγ null mice do not display T and B cell leakiness. Exp Anim 2011; 60: 181–186.
  CAS PubMed Google Scholar
• Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Ohbo K et al. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol 1996; 14: 179–205.
  CAS PubMed Google Scholar
• Okada S, Harada H, Ito T, Saito T, Suzu S . Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells. Int J Hematol 2008; 88: 476–482.
  PubMed Google Scholar
• Sato Y, Takata H, Kobayashi N, Nagata S, Nakagata N, Ueno T et al. Failure of effector function of human CD8+ T cells in NOD/SCID/JAK3/ immunodeficient mice transplanted with human CD34+ hematopoietic stem cells. PLoS One 2010; 5: e13109.
  PubMed PubMed Central Google Scholar
• Miyakawa Y, Fukuchi Y, Ito M, Kobayashi K, Kuramochi T, Ikeda Y et al. Establishment of human granulocyte–macrophage colony stimulating factor produing transgenic SCID mice. Br J Haematol 1996; 95: 437–442.
  CAS PubMed Google Scholar
• Fukuchi Y, Miyakawa Y, Kobayashi K, Kuramochi T, Shimamura K, Tamaoki N et al. Cytokine dependent growth of human TF-1 leukemic cell line in human GM-CSF and IL-3 producing transgenic SCID mice. Leuk Res 1998; 22: 837–843.
  CAS PubMed Google Scholar
• Takenaka K, Prasolava TK, Wang JC, Mortin-Toth SM, Khalouei S, Gan OI et al. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol 2007; 8: 1313–1323.
  CAS PubMed Google Scholar
• Takizawa H, Manz MG . Macrophage tolerance: CD47-SIRP-α-mediated signals matter. Nat Immunol 2007; 8: 1287–1289.
  CAS PubMed Google Scholar
• Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ et al. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc Natl Acad Sci USA 2011; 108: 2378–2383.
  CAS PubMed PubMed Central Google Scholar
• Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ et al. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc Natl Acad Sci USA 2011; 108: 2390–2395.
  CAS PubMed PubMed Central Google Scholar
• Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M et al. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγnull humanized mice. Proc Natl Acad Sci USA 2010; 107: 13022–13027.
  CAS PubMed PubMed Central Google Scholar
• Danner R, Chaudhari SN, Rosenberger J, Surls J, Richie TL, Brumeanu TD et al. Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells. PLoS One 2011; 6: e19826.
  CAS PubMed PubMed Central Google Scholar
• Hiramatsu H, Nishikomori R, Heike T, Ito M, Kobayashi K, Katamura K et al. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γcnull mice model. Blood 2003; 102: 873–880.
  CAS PubMed Google Scholar
• Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H et al. T cell-mediated control of Epstein–Barr virus infection in humanized mice. J Infect Dis 2009; 200: 1611–1615.
  CAS PubMed Google Scholar
• Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M et al. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγnull humanized mice. Proc Natl Acad Sci USA 2010; 107: 13022–13027.
  CAS PubMed PubMed Central Google Scholar
• Strowig T, Gurer C, Ploss A, Liu YF, Arrey F, Sashihara J et al. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med 2009; 206: 1423–1434.
  PubMed PubMed Central Google Scholar
• Suwanai H, Wilcox MA, Mathis D, Benoist C . A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. Proc Natl Acad Sci USA 01; 107: 9305–9310.
  CAS Google Scholar
• Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A et al. IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med 2009; 206: 25–34.
  CAS PubMed PubMed Central Google Scholar
• Chen Q, Khoury M, Chen J . Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci USA 2009; 106: 21783–21788.
  CAS PubMed PubMed Central Google Scholar
• Shiokawa M, Takahashi T, Murakami A, Kita S, Ito M, Sugamura K et al. In vivo assay of human NK-dependent ADCC using NOD/SCID/γcnull (NOG) mice. Biochem Biophys Res Commun 2010; 399: 733–737.
  CAS PubMed Google Scholar
• Billerbeck E, Barry WT, Mu K, Dorner M, Rice CM, Ploss A . Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocytenmacrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rγnull humanized mice. Blood 2011; 117: 3076–3086.
  CAS PubMed PubMed Central Google Scholar
• Williams CM, Galli SJ . The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 2000; 105: 847–859.
  CAS PubMed Google Scholar
• Galli SJ, Wershil BK . The two faces of the mast cell. Nature 1996; 381: 21–22.
  CAS PubMed Google Scholar
• Kambe N, Hiramatsu H, Shimonaka M, Fujino H, Nishikomori R, Heike T et al. Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body. Blood 2004; 103: 860–867.
  CAS PubMed Google Scholar
• Machida K, Suemizu H, Kawai K, Ishikawa T, Sawada R, Ohnishi Y et al. Higher susceptibility of NOG mice to xenotransplanted tumors. J Toxicol Sci 2009; 34: 123–127.
  PubMed Google Scholar
• Suemizu H, Monnai M, Ohnishi Y, Ito M, Tamaoki N, Nakamura M . Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/γcnull (NOG) mice. Int J Oncol 2007; 31: 741–751.
  CAS PubMed Google Scholar
• Miyakawa Y, Ohnishi Y, Tomisawa M, Monnai M, Kohmura K, Ueyama Y et al. Establishment of a new model of human multiple myeloma using NOD/SCID/γcnull (NOG) mice. Biochem Biophys Res Commun 2004; 313: 258–262.
  CAS PubMed Google Scholar
• Ninomiya M, Kiyoi H, Ito M, Hirose Y, Naoe T . Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line. Leukemia 2004; 18: 442–448.
  CAS PubMed Google Scholar
• Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T et al. Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. Transplantation 2009; 87: 1654–1658.
  CAS PubMed Google Scholar
• Zhang L, Meissner E, Chen J, Su L . Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci 2010; 53: 195–203.
  CAS PubMed PubMed Central Google Scholar
• Namikawa R, Kaneshima H, Lieberman M, Weissman IL, McCune JM . Infection of the SCID-hu mouse by HIV-1. Science 1988; 242: 1684–1686.
  CAS PubMed Google Scholar
• Mosier DE, Gulizia RJ, Baird SM, Wilson DB . Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1988; 335: 256–259.
  CAS PubMed Google Scholar
• Koyanagi Y, Tanaka Y, Ito M, Yamamoto N . Humanized mice for human retrovirus infection. Curr Top Microbiol Immunol 2008; 324: 133–148.
  CAS PubMed Google Scholar
• Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y . Dynamics of memory and naive CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rγnull mice infected with CCR5-tropic HIV-1. Vaccine 8 2010; Suppl 2, B32–37.
  CAS PubMed Google Scholar
• Watanabe S, Ohta S, Yajima M, Terashima K, Ito M, Mugishima H et al. Humanized NOD/SCID/IL2Rγnull mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis. J Virol 2007; 81: 13259–13264.
  CAS PubMed PubMed Central Google Scholar
• Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y et al. Hematopoietic stem cell-engrafted NOD/SCID/IL2Rγnull mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood 2007; 109: 212–218.
  CAS PubMed Google Scholar
• Denton PW, Estes JD, Sun Z, Othieno FA, Wei BL, Wege AK et al. Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med 2008; 5: e16.
  PubMed PubMed Central Google Scholar
• Olesen R, Wahl A, Denton PW, Garcia JV . Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection. J Reprod Immunol 2011; 88: 195–203.
  CAS PubMed PubMed Central Google Scholar
• Choudhary S, Archin N, Cheema M, Dahl N, Garcia JV, Margolis D . Latent HIV-1 infection of resting CD4+ T cells in the humanized Rag2−/−γc−/− mouse. J Virol 2012; 86: 114–120.
  CAS PubMed PubMed Central Google Scholar
• Rickinson AB, Kieff E . Epstein–Barr virus. In: Knipe DM, Howley PM (eds.) Fields virology. Philadelphia: Lippincott Williams & Wilkins, 2011: 2575–2628.
• Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H et al. A new humanized mouse model of Epstein–Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses. J Infect Dis 2008; 198: 673–682.
  CAS PubMed Google Scholar
• Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M et al. A novel animal model of Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice. Blood 2011; 117: 5663–5673.
  CAS PubMed Google Scholar
• Imadome K, Yajima M, Arai A, Nakazawa A, Kawano F, Ichikawa S et al. Novel mouse xenograft models reveal a critical role of CD4+ T cells in the proliferation of EBV-infected T and NK cells. PLoS Pathog 2011; 7: e1002326.
  CAS PubMed PubMed Central Google Scholar
• Song J, Willinger T, Rongvaux A, Eynon EE, Stevens S, Manz MG et al. A mouse model for the human pathogen Salmonella typhi. Cell Host Microbe 2010; 8: 369–376.
  CAS PubMed PubMed Central Google Scholar
• Libby SJ, Brehm MA, Greiner DL, Shultz LD, McClelland M, Smith KD et al. Humanized nonobese diabetic-scid IL2rγ null mice are susceptible to lethal Salmonella typhi infection. Proc Natl Acad Sci USA 2010; 107: 15589–15594.
  CAS PubMed PubMed Central Google Scholar
• Firoz Mian M, Pek EA, Chenoweth MJ, Ashkar AA . Humanized mice are susceptible to Salmonella typhi infection. Cell Mol Immunol 2011; 8: 83–87.
  CAS PubMed Google Scholar
• Sauerwein RW, Roestenberg M, Moorthy VS . Experimental human challenge infections can accelerate clinical malaria vaccine development. Nat Rev Immunol 2011; 11: 57–64.
  CAS PubMed Google Scholar
• Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E et al. Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice. Nat Biotechnol 2007; 25: 903–910.
  CAS PubMed PubMed Central Google Scholar
• Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M et al. The reconstituted ‘humanized liver’ in TK-NOG mice is mature and functional. Biochem Biophys Res Commun 2011; 405: 405–410.
  CAS PubMed PubMed Central Google Scholar
• Mercer DF, Schiller DE, Elliott JF, Douglas DN, Hao C, Rinfret A et al. Hepatitis C virus replication in mice with chimeric human livers. Nat Med 2001; 7: 927–933.
  CAS PubMed Google Scholar
• Suemizu H, Hasegawa M, Kawai K, Taniguchi K, Monnai M, Wakui M et al. Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice. Biochem Biophys Res Commun 2008; 377: 248–252.
  CAS PubMed Google Scholar
• Mikolajczak SA, Sacci JB Jr, de la Vega P, Camargo N, VanBuskirk K, Krzych U et al. Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites. Cell Microbiol 2011; 13: 1250–1260.
  CAS PubMed PubMed Central Google Scholar
• Jimenez-Diaz MB, Mulet T, Viera S, Gomez V, Garuti H, Ibanez J et al. Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rγ null mice engrafted with human erythrocytes. Antimicrob Agents Chemother 2009; 53: 4533–4536.
  CAS PubMed PubMed Central Google Scholar
• Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, Chisari FV et al. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest 2010; 120: 924–930.
  CAS PubMed PubMed Central Google Scholar
• Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M et al. Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice. Am J Pathol 2009; 175: 1483–1492.
  CAS PubMed PubMed Central Google Scholar
• Washburn ML, Bility MT, Zhang L, Kovalev GI, Buntzman A, Frelinger JA et al. A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. Gastroenterology 2011; 140: 1334–1344.
  CAS PubMed Google Scholar
• Martino G, Anastasi J, Feng J, Mc Shan C, DeGroot L, Quintans J et al. The fate of human peripheral blood lymphocytes after transplantation into SCID mice. Eur J Immunol 1993; 23: 1023–1028.
  CAS PubMed Google Scholar
• van Rijn RS, Simonetti ER, Hagenbeek A, Hogenes MC, de Weger RA, Canninga-van Dijk MR et al. A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2−/− γc−/− double-mutant mice. Blood 2003; 102: 2522–2531.
  CAS PubMed Google Scholar
• King MA, Covassin L, Brehm MA, Racki W, Pearson T, Leif J et al. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 2009; 157: 104–118.
  CAS PubMed PubMed Central Google Scholar