The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability (original) (raw)

• Wang W . Emergence of a DNA-damage response network consisting of Fanconi anemia and BRCA proteins. Nat Rev Genet 2007; 8:doi:10.1038/nrg2159.
  Article CAS Google Scholar
• Kim H, D'Andrea AD . Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev 2012; 26:1393–1408.
  Article CAS Google Scholar
• Kottemann MC, Smogorzewska A . Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature 2013; 493:356–363.
  Article CAS Google Scholar
• Bogliolo M, Schuster B, Stoepker C, et al. Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. Am J Hum Genet 2013; 92:800–806.
  Article CAS Google Scholar
• Kashiyama K, Nakazawa Y, Pilz DT, et al. Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia. Am J Hum Genet 2013; 92:807–819.
  Article CAS Google Scholar
• Meetei AR, Medhurst AL, Ling C, et al. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet 2005; 37:958–963.
  Article CAS Google Scholar
• Mosedale G, Niedzwiedz W, Alpi A, et al. The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat Struct Mol Biol 2005; 12:763–771.
  Article CAS Google Scholar
• Gari K, Decaillet C, Delannoy M, Wu L, Constantinou A . Remodeling of DNA replication structures by the branch point translocase FANCM. Proc Natl Acad Sci USA 2008; 105:16107–16112.
  Article CAS Google Scholar
• Gari K, Decaillet C, Stasiak AZ, Stasiak A, Constantinou A . The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol Cell 2008; 29:141–148.
  Article CAS Google Scholar
• Xue Y, Li Y, Guo R, Ling C, Wang W . FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair. Hum Mol Genet 2008; 17:1641–1652.
  Article CAS Google Scholar
• Sun W, Nandi S, Osman F, et al. The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair. Mol Cell 2008; 32:118–128.
  Article CAS Google Scholar
• Blackford AN, Schwab RA, Nieminuszczy J, Deans AJ, West SC, Niedzwiedz W . The DNA translocase activity of FANCM protects stalled replication forks. Hum Mol Genet 2012; 21:2005–2016.
  Article CAS Google Scholar
• Luke-Glaser S, Luke B, Grossi S, Constantinou A . FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling. EMBO J 2010; 29:795–805.
  Article CAS Google Scholar
• Yan Z, Delannoy M, Ling C, et al. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell 2010; 37:865–878.
  Article CAS Google Scholar
• Daee DL, Ferrari E, Longerich S, et al. Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1. J Biol Chem 2012; 287:26563–26575.
  Article CAS Google Scholar
• Wang Y, Leung JW, Jiang Y, et al. FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Mol Cell 2013; 49:997–1009.
  Article CAS Google Scholar
• Singh TR, Bakker ST, Agarwal S, et al. Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. Blood 2009; 114:174–180.
  Article CAS Google Scholar
• Rosado IV, Niedzwiedz W, Alpi AF, Patel KJ . The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair. Nucleic Acids Res 2009; 37:4360–4370.
  Article CAS Google Scholar
• Singh TR, Saro D, Ali AM, et al. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol Cell 2010; 37:879–886.
  Article CAS Google Scholar
• Nishino T, Takeuchi K, Gascoigne KE, et al. CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. Cell 2012; 148:487–501.
  Article CAS Google Scholar
• Yang H, Zhang T, Tao Y, et al. Saccharomyces cerevisiae MHF complex structurally resembles the histones (H3-H4)(2) heterotetramer and functions as a heterotetramer. Structure 2012; 20:364–370.
  Article Google Scholar
• Tao Y, Jin C, Li X, et al. The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nat Commun 2012; 3:782.
  Article Google Scholar
• Hori T, Amano M, Suzuki A, et al. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Cell 2008; 135:1039–1052.
  Article CAS Google Scholar
• ACOG Committee Opinion No. 469: Carrier screening for fragile X syndrome. Obstet Gynecol; 116:1008–1010.
• Amano M, Suzuki A, Hori T, et al. The CENP-S complex is essential for the stable assembly of outer kinetochore structure. J Cell Biol 2009; 186:173–182.
  Article CAS Google Scholar
• Richards FM, Kundrot CE . Identification of structural motifs from protein coordinate data: secondary structure and first-level supersecondary structure. Proteins 1988; 3:71–84.
  Article CAS Google Scholar
• Bhattacharjee S, Osman F, Feeney L, Lorenz A, Bryer C, Whitby MC . MHF1-2/CENP-S-X performs distinct roles in centromere metabolism and genetic recombination. Open Biol 2013; 3:130102.
  Article Google Scholar
• Albright SR, Tjian R . TAFs revisited: more data reveal new twists and confirm old ideas. Gene 2000; 242:1–13.
  Article CAS Google Scholar
• Liu N, Balliano A, Hayes JJ . Mechanism(s) of SWI/SNF-induced nucleosome mobilization. Chembiochem 2011; 12:196–204.
  Article CAS Google Scholar
• Elmlund H, Baraznenok V, Linder T, et al. Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID. Structure 2009; 17:1442–1452.
  Article CAS Google Scholar
• Zhao Q, Saro D, Sachpatzidis A, et al. The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun 2014; 5:2987.
  Article Google Scholar
• Ciccia A, Ling C, Coulthard R, et al. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell 2007; 25:331–343.
  Article CAS Google Scholar
• Kabsch W . Automatic indexing of rotation diffraction patterns. J Appl Cryst 1988; 21:67–72.
  Article CAS Google Scholar
• Kabsch W . Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constrants. J Appl Cryst 1993; 26:795–800.
  Article CAS Google Scholar
• Kabsch W . XDS. Acta Crystallogr D Biol Crystallogr 2010; 66(Pt2):125–132.
  Article Google Scholar
• Murshudov GN, Vagin AA, Dodson EJ . Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr 1997; 53:240–255.
  Article CAS Google Scholar
• Winn MD, Ballard CC, Cowtan KD, et al. Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr 2011; 67:235–242.
  Article CAS Google Scholar
• Emsley P, Cowtan K . Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 2004; 60:2126–2132.
  Article Google Scholar
• Chen VB, Arendall WB III, Headd JJ, et al. MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr 2010; 66:12–21.
  Article CAS Google Scholar
• Berman H, Henrick K, Nakamura H . Announcing the worldwide Protein Data Bank. Nat Struct Biol 2003; 10:980.
  Article CAS Google Scholar
• Berman HM, Westbrook J, Feng Z, et al. The Protein Data Bank. Nucleic Acids Res 2000; 28:235–242.
  Article CAS Google Scholar
• Hori T, Haraguchi T, Hiraoka Y, Kimura H, Fukagawa T . Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells. J Cell Sci 2003; 116:3347–3362.
  Article CAS Google Scholar
• Schrodinger L . The PyMOL Molecular Graphics System, Version 0.99.