Identification of blood biomarkers for psychosis using convergent functional genomics (original) (raw)

• Niculescu A, Segal D, Kuczenski R, Barrett T, Hauger R, Kelsoe J . Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiol Genomics 2000; 4: 83–91.
  Article CAS PubMed Google Scholar
• Ogden CA, Rich ME, Schork NJ, Paulus MP, Geyer MA, Lohr JB et al. Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach. Mol Psychiatry 2004; 9: 1007–1029.
  Article CAS PubMed Google Scholar
• Rodd ZA, Bertsch BA, Strother WN, Le-Niculescu H, Balaraman Y, Hayden E et al. Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. Pharmacogenomics J 2007; 7: 222–256.
  Article CAS PubMed Google Scholar
• Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE et al. Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. Am J Med Genet B Neuropsychiatr Genet 2007; 144B: 129–158.
  Article CAS PubMed Google Scholar
• Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ et al. Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry 2009; 14: 156–174.
  Article CAS PubMed Google Scholar
• Middleton FA, Pato CN, Gentile KL, McGann L, Brown AM, Trauzzi M et al. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am J Med Genet B Neuropsychiatr Genet 2005; 136: 12–25.
  Article Google Scholar
• Morrison JL, Breitling R, Higham DJ, Gilbert DR . GeneRank: using search engine technology for the analysis of microarray experiments. BMC Bioinformatics 2005; 6: 233.
  Article PubMed PubMed Central CAS Google Scholar
• Le-Niculescu H, McFarland MJ, Mamidipalli S, Ogden CA, Kuczenski R, Kurian SM et al. Convergent functional genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers. Neurosci Biobehav Rev 2007; 31: 897–903.
  Article CAS PubMed PubMed Central Google Scholar
• Vawter MP, Crook JM, Hyde TM, Kleinman JE, Weinberger DR, Becker KG et al. Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study. Schizophr Res 2002; 58: 11–20.
  Article PubMed Google Scholar
• Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP et al. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci USA 2005; 102: 15653–15658.
  Article CAS PubMed PubMed Central Google Scholar
• Vawter MP, Tomita H, Meng F, Bolstad B, Li J, Evans S et al. Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders. Mol Psychiatry 2006; 11, 615, 663–679.
  Article CAS Google Scholar
• Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ et al. PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes. Am J Med Genet B Neuropsychiatr Genet 2006; 141: 653–662.
  Article Google Scholar
• Le-Niculescu H, Patel SD, Bhat M, Kuczenski R, Faraone SV, Tsuang MT et al. Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms. Am J Med Genet B Neuropsychiatr Genet 2009; 150B: 155–181.
  Article CAS PubMed Google Scholar
• Niculescu 3rd AB . Polypharmacy in oligopopulations: what psychiatric genetics can teach biological psychiatry. Psychiatr Genet 2006; 16: 241–244.
  Article PubMed Google Scholar
• Glatt SJ, Faraone SV, Lasky-Su JA, Kanazawa T, Hwu HG, Tsuang MT . Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan. Mol Psychiatry 2008; 14: 885–893.
  Article PubMed PubMed Central CAS Google Scholar
• Georgieva L, Dimitrova A, Ivanov D, Nikolov I, Williams NM, Grozeva D et al. Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia. Biol Psychiatry 2008; 64: 419–427.
  Article CAS PubMed Google Scholar
• Goes FS, Willour VL, Zandi PP, Belmonte PL, Mackinnon DF, Mondimore FM et al. Family-based association study of Neuregulin 1 with psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2009; 150B: 693–702.
  Article CAS PubMed Google Scholar
• Serretti A, Lattuada E, Lorenzi C, Lilli R, Smeraldi E . Dopamine receptor D2 Ser/Cys 311 variant is associated with delusion and disorganization symptomatology in major psychoses. Mol Psychiatry 2000; 5: 270–274.
  Article CAS PubMed Google Scholar
• Spalletta G, Bernardini S, Bellincampi L, Federici G, Trequattrini A, Caltagirone C . Delusion symptoms are associated with ApoE epsilon4 allelic variant at the early stage of Alzheimer's disease with late onset. Eur J Neurol 2006; 13: 176–182.
  Article CAS PubMed Google Scholar
• Dean B, Digney A, Sundram S, Thomas E, Scarr E . Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder. Psychiatry Res 2008; 158: 75–78.
  Article CAS PubMed Google Scholar
• Maloney B, Ge YW, Petersen RC, Hardy J, Rogers JT, Perez-Tur J et al. Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: differential effects in neuronal cells and on DNA-protein interactions. Am J Med Genet B Neuropsychiatr Genet, (2011) 16, –;, 5 June 2009; e-pub ahead of print.
• Papadopoulos T, Korte M, Eulenburg V, Kubota H, Retiounskaia M, Harvey RJ et al. Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. Embo J 2007; 26: 3888–3899.
  Article CAS PubMed PubMed Central Google Scholar
• Marco EJ, Abidi FE, Bristow J, Dean WB, Cotter P, Jeremy RJ et al. ARHGEF9 disruption in a female patient is associated with X linked mental retardation and sensory hyperarousal. J Med Genet 2008; 45: 100–105.
  Article CAS PubMed Google Scholar
• Anthony TE, Heintz N . The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects. J Comp Neurol 2007; 500: 368–383.
  Article CAS PubMed Google Scholar
• Mahadik SP, Mukherjee S, Wakade CG, Laev H, Reddy RR, Schnur DB . Decreased adhesiveness and altered cellular distribution of fibronectin in fibroblasts from schizophrenic patients. Psychiatry Res 1994; 53: 87–97.
  Article CAS PubMed Google Scholar
• Miyamae Y, Nakamura Y, Kashiwagi Y, Tanaka T, Kudo T, Takeda M . Altered adhesion efficiency and fibronectin content in fibroblasts from schizophrenic patients. Psychiatry Clin Neurosci 1998; 52: 345–352.
  Article CAS PubMed Google Scholar
• Bassett DS, Bullmore E, Verchinski BA, Mattay VS, Weinberger DR, Meyer-Lindenberg A . Hierarchical organization of human cortical networks in health and schizophrenia. J Neurosci 2008; 28: 9239–9248.
  Article CAS PubMed PubMed Central Google Scholar
• Sun D, Stuart GW, Jenkinson M, Wood SJ, McGorry PD, Velakoulis D et al. Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Mol Psychiatry 2008; 14: 976–986.
  Article PubMed PubMed Central Google Scholar
• Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ et al. Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry 2008; 14: 156–174.
  Article CAS PubMed Google Scholar
• Shirts BH, Wood J, Yolken RH, Nimgaonkar VL . Comprehensive evaluation of positional candidates in the IL-18 pathway reveals suggestive associations with schizophrenia and herpes virus seropositivity. Am J Med Genet B Neuropsychiatr Genet 2008; 147: 343–350.
  Article PubMed CAS Google Scholar
• Brown AS, Hooton J, Schaefer CA, Zhang H, Petkova E, Babulas V et al. Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am J Psychiatry 2004; 161: 889–895.
  Article PubMed Google Scholar
• Zhang XY, Zhou DF, Zhang PY, Wu GY, Cao LY, Shen YC . Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Schizophrenia Res 2002; 57: 247–258.
  Article Google Scholar
• Garcia-Bueno B, Caso JR, Leza JC . Stress as a neuroinflammatory condition in brain: damaging and protective mechanisms. Neurosci Biobehav Rev 2008; 32: 1136–1151.
  Article CAS PubMed Google Scholar
• Lau CG, Zukin RS . NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev 2007; 8: 413–426.
  Article CAS Google Scholar
• Kanakry CG, Li Z, Nakai Y, Sei Y, Weinberger DR . Neuregulin-1 regulates cell adhesion via an ErbB2/phosphoinositide-3 kinase/Akt-dependent pathway: potential implications for schizophrenia and cancer. PLoS ONE 2007; 2: e1369.
  Article PubMed PubMed Central CAS Google Scholar
• Schonfeldt-Lecuona C, Freudenmann RW, Tumani H, Kassubek J, Connemann BJ . Acute psychosis with a mediastinal carcinoma metastasis. Med Sci Monit 2005; 11: CS6–CS8.
  PubMed Google Scholar
• Wei Z, Qi J, Dai Y, Bowen WD, Mousseau DD . Haloperidol disrupts Akt signalling to reveal a phosphorylation-dependent regulation of pro-apoptotic Bcl-XS function. Cell Signalling 2009; 21: 161–168.
  Article CAS PubMed Google Scholar
• Riedel M, Strassnig M, Schwarz MJ, Muller N . COX-2 inhibitors as adjunctive therapy in schizophrenia: rationale for use and evidence to date. CNS Drugs 2005; 19: 805–819.
  Article CAS PubMed Google Scholar
• Laan W, Smeets H, de Wit NJ, Kahn RS, Grobbee DE, Burger H . Glucocorticosteroids associated with a decreased risk of psychosis. J Clin Psychopharmacol 2009; 29: 288–290.
  Article CAS PubMed Google Scholar
• Peet M . Omega-3 polyunsaturated fatty acids in the treatment of schizophrenia. Israel J Psychiatry Relat Sci 2008; 45: 19–25.
  Google Scholar
• Huang JT, Wang L, Prabakaran S, Wengenroth M, Lockstone HE, Koethe D et al. Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues. Mol Psychiatry 2008; 13: 1118–1128.
  Article CAS PubMed Google Scholar
• Sawa A, Cascella NG . Peripheral olfactory system for clinical and basic psychiatry: a promising entry point to the mystery of brain mechanism and biomarker identification in schizophrenia. Am J Psychiatry 2009; 166: 137–139.
  Article PubMed Google Scholar
• Kato T, Iwayama Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y et al. Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia. Mol Psychiatry 2005; 10: 1045–1055.
  Article CAS PubMed Google Scholar
• Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE et al. Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. Am J Med Genet B Neuropsychiatr Genet 2007; 144: 129–158.
  Article CAS Google Scholar
• Paunio T, Tuulio-Henriksson A, Hiekkalinna T, Perola M, Varilo T, Partonen T et al. Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q. Hum Mol Genet 2004; 13: 1693–1702.
  Article CAS PubMed Google Scholar
• Kim S, Choi KH, Baykiz AF, Gershenfeld HK . Suicide candidate genes associated with bipolar disorder and schizophrenia: an exploratory gene expression profiling analysis of post-mortem prefrontal cortex. BMC Genomics 2007; 8: 413.
  Article PubMed PubMed Central Google Scholar
• Glatt SJ, Everall IP, Kremen WS, Corbeil J, Sasik R, Khanlou N et al. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proc Natl Acad Sci USA 2005; 102: 15533–15538.
  Article CAS PubMed PubMed Central Google Scholar
• Vawter MP, Ferran E, Galke B, Cooper K, Bunney WE, Byerley W . Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree. Schizophr Res 2004; 67: 41–52.
  Article PubMed Google Scholar
• Bowden NA, Weidenhofer J, Scott RJ, Schall U, Todd J, Michie PT et al. Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia. Schizophrenia Res 2006; 82: 175–183.
  Article Google Scholar
• Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS . Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 2000; 288: 678–682.
  Article CAS PubMed PubMed Central Google Scholar
• Dean B, Pavey G, Scarr E, Goeringer K, Copolov DL . Measurement of dopamine D2-like receptors in postmortem CNS and pituitary: differential regional changes in schizophrenia. Life Sci 2004; 74: 3115–3131.
  Article CAS PubMed Google Scholar
• Seeman P, Guan HC, Nobrega J, Jiwa D, Markstein R, Balk JH et al. Dopamine D2-like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3 H]benzquinoline. Synapse 1997; 25: 137–146.
  Article CAS PubMed Google Scholar
• Torrey EF, Barci BM, Webster MJ, Bartko JJ, Meador-Woodruff JH, Knable MB . Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains. Biol Psychiatry 2005; 57: 252–260.
  Article CAS PubMed Google Scholar
• Zvara A, Szekeres G, Janka Z, Kelemen JZ, Cimmer C, Santha M et al. Over-expression of dopamine D2 receptor and inwardly rectifying potassium channel genes in drug-naive schizophrenic peripheral blood lymphocytes as potential diagnostic markers. Dis Markers 2005; 21: 61–69.
  Article CAS PubMed PubMed Central Google Scholar
• Sun J, Kuo PH, Riley BP, Kendler KS, Zhao Z . Candidate genes for schizophrenia: a survey of association studies and gene ranking. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 1173–1181.
  Article PubMed Google Scholar
• Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 2008; 40: 827–834.
  Article CAS PubMed Google Scholar
• Yamada K, Gerber DJ, Iwayama Y, Ohnishi T, Ohba H, Toyota T et al. Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc Natl Acad Sci USA 2007; 104: 2815–2820.
  Article CAS PubMed PubMed Central Google Scholar
• Straub RE, MacLean CJ, O'Neill FA, Walsh D, Kendler KS . Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol Psychiatry 1997; 2: 148–155.
  Article CAS PubMed Google Scholar
• Devlin B, Bacanu SA, Roeder K, Reimherr F, Wender P, Galke B et al. Genome-wide multipoint linkage analyses of multiplex schizophrenia pedigrees from the oceanic nation of Palau. Mol Psychiatry 2002; 7: 689–694.
  Article CAS PubMed Google Scholar
• Smalla KH, Mikhaylova M, Sahin J, Bernstein HG, Bogerts B, Schmitt A et al. A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia. Mol Psychiatry 2008; 13: 878–896.
  Article CAS PubMed Google Scholar
• Faraone SV, Lasky-Su J, Glatt SJ, Van Eerdewegh P, Tsuang MT . Early onset bipolar disorder: possible linkage to chromosome 9q34. Bipolar Disord 2006; 8: 144–151.
  Article CAS PubMed Google Scholar
• Kampman O, Anttila S, Illi A, Mattila KM, Rontu R, Leinonen E et al. Apolipoprotein E polymorphism is associated with age of onset in schizophrenia. J Hum Genet 2004; 49: 355–359.
  Article CAS PubMed Google Scholar
• Hahn CG, Wang HY, Cho DS, Talbot K, Gur RE, Berrettini WH et al. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med 2006; 12: 824–828.
  Article CAS PubMed Google Scholar
• Petryshen TL, Middleton FA, Kirby A, Aldinger KA, Purcell S, Tahl AR et al. Support for involvement of neuregulin 1 in schizophrenia pathophysiology. Mol Psychiatry 2005; 10: 366–374, 328.
  Article CAS PubMed Google Scholar
• Chagnon YC, Roy MA, Bureau A, Merette C, Maziade M . Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes. Schizophrenia Res 2008; 100: 281–290.
  Article CAS Google Scholar
• Zhang HX, Zhao JP, Lv LX, Li WQ, Xu L, Ouyang X et al. Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia. Neurosci Lett 2008; 438: 1–5.
  Article CAS PubMed Google Scholar
• Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G et al. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 1998; 20: 70–73.
  Article CAS PubMed Google Scholar
• Chiu YF, McGrath JA, Thornquist MH, Wolyniec PS, Nestadt G, Swartz KL et al. Genetic heterogeneity in schizophrenia II: conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q. Mol Psychiatry 2002; 7: 658–664.
  Article CAS PubMed Google Scholar
• Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS et al. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 2001; 68: 661–673.
  Article CAS PubMed PubMed Central Google Scholar
• Pulver AE, Mulle J, Nestadt G, Swartz KL, Blouin JL, Dombroski B et al. Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes. Mol Psychiatry 2000; 5: 650–653.
  Article CAS PubMed Google Scholar
• Suarez BK, Duan J, Sanders AR, Hinrichs AL, Jin CH, Hou C et al. Genomewide linkage scan of 409 European-Ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Am J Hum Genet 2006; 78: 315–333.
  Article CAS PubMed PubMed Central Google Scholar
• Kaufmann CA, Suarez B, Malaspina D, Pepple J, Svrakic D, Markel PD et al. NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. Am J Med Genet 1998; 81: 282–289.
  Article CAS PubMed Google Scholar
• Arion D, Unger T, Lewis DA, Levitt P, Mirnics K . Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry 2007; 62: 711–721.
  Article CAS PubMed PubMed Central Google Scholar
• DeLisi LE, Shaw SH, Crow TJ, Shields G, Smith AB, Larach VW et al. A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder. Am J Psychiatry 2002; 159: 803–812.
  Article PubMed Google Scholar
• Straub RE, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C et al. Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes. Mol Psychiatry 2002; 7: 542–559.
  Article CAS PubMed Google Scholar
• Clark D, Dedova I, Cordwell S, Matsumoto I . A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia. Mol Psychiatry 2006; 11: 459–470, 423.
  Article CAS PubMed Google Scholar
• Takahashi S, Faraone SV, Lasky-Su J, Tsuang MT . Genome-wide scan of homogeneous subtypes of NIMH genetics initiative schizophrenia families. Psychiatry Res 2005; 133: 111–122.
  Article CAS PubMed Google Scholar
• Cardno AG, Holmans PA, Rees MI, Jones LA, McCarthy GM, Hamshere ML et al. A genomewide linkage study of age at onset in schizophrenia. Am J Med Genet 2001; 105: 439–445.
  Article CAS PubMed Google Scholar
• Vawter MP, Barrett T, Cheadle C, Sokolov BP, Wood 3rd WH, Donovan DM et al. Application of cDNA microarrays to examine gene expression differences in schizophrenia. Brain Res Bull 2001; 55: 641–650.
  Article CAS PubMed Google Scholar
• Mudge J, Miller NA, Khrebtukova I, Lindquist IE, May GD, Huntley JJ et al. Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum. PLoS ONE 2008; 3: e3625.
  Article PubMed PubMed Central CAS Google Scholar
• Aston C, Jiang L, Sokolov BP . Microarray analysis of postmortem temporal cortex from patients with schizophrenia. J Neurosci Res 2004; 77: 858–866.
  Article CAS PubMed Google Scholar
• McInnes LA, Lauriat TL . RNA metabolism and dysmyelination in schizophrenia. Neurosci Biobehav Rev 2006; 30: 551–561.
  Article CAS PubMed Google Scholar
• Fallin MD, Lasseter VK, Wolyniec PS, McGrath JA, Nestadt G, Valle D et al. Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22. Am J Hum Genet 2003; 73: 601–611.
  Article CAS PubMed PubMed Central Google Scholar
• Sullivan PF, Lin D, Tzeng JY, van den Oord E, Perkins D, Stroup TS et al. Genomewide association for schizophrenia in the CATIE study: results of stage 1. Mol Psychiatry 2008; 13: 570–584.
  Article CAS PubMed PubMed Central Google Scholar
• Benes FM, Lim B, Matzilevich D, Subburaju S, Walsh JP . Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars. Proc Natl Acad Sci USA 2008; 105: 20935–20940.
  Article CAS PubMed PubMed Central Google Scholar
• Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science (New York, NY) 2008; 320: 539–543.
  Article CAS Google Scholar