Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia (original) (raw)
O’Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 2008; 40: 1053–1055. ArticlePubMed Google Scholar
Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D et al. Common variants conferring risk of schizophrenia. Nature 2009; 460: 744–747. CASPubMedPubMed Central Google Scholar
Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe’er I et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 2009; 460: 753–757. CASPubMedPubMed Central Google Scholar
Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA et al. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011; 43: 969–976. ArticleCAS Google Scholar
Sullivan PF, Lin D, Tzeng JY, van den Oord E, Perkins D, Stroup TS et al. Genomewide association for schizophrenia in the CATIE study: results of stage 1 [published erratum appears in MolPsychiatry 2009; 14:1144]. Mol Psychiatry 2008; 13: 570–584. ArticleCASPubMedPubMed Central Google Scholar
Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E et al. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Mol Psychiatry 2009; 14: 252–260. CASPubMed Google Scholar
Purcell SM, Wray NR, Stone JL, Visscher PM, O’Donovan MC, Sullivan PF et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460: 748–752. CASPubMed Google Scholar
Potash JB . Carving chaos: genetics and the classification of mood and psychotic syndromes. Harv Rev Psychiatry 2006; 14: 47–63. ArticlePubMed Google Scholar
Jablensky A . Subtyping schizophrenia: implications for genetic research. Mol Psychiatry 2006; 11: 815–836. ArticleCASPubMed Google Scholar
Woodbury MA, Clive J, Garson Jr A . Mathematical typology: a grade of membership technique for obtaining disease definition. Comput Biomed Res 1978; 11: 277–298. ArticleCASPubMed Google Scholar
Loughland C, Draganic D, McCabe K, Richards J, Nasir A, Allen J et al. Australian Schizophrenia Research Bank: a database of comprehensive clinical, endophenotypic, and genetic data for aetiological studies of schizophrenia. Aust N Z Psychiatry 2011; 44: 1029–1035. Google Scholar
Hallmayer JF, Kalaydjieva L, Badcock J, Dragovic M, Howell S, Michie PT et al. Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit. Am J Hum Genet 2005; 77: 468–476. ArticleCASPubMedPubMed Central Google Scholar
Morar B, Dragovic M, Waters FAV, Chandler D, Kalaydjieva L, Jablensky A . Neuregulin 3 (NRG3) as a susceptibility gene in a schizophrenia subtype with florid delusions and relatively spared cognition. Mol Psychiatry 2010; 16: 860–866. ArticlePubMed Google Scholar
Kendler KS, Zachar P, Craver C . Whate kinds of things are psychiatric disorders? Psychol Med 2011; 41: 1143–1150. ArticleCASPubMed Google Scholar
Potkin SG, Macciardi F, Guffanti G, Fallon JH, Wang Q, Turner JA et al. Identifying gene regulatory networks in schizophrenia. Neuroimage 2010; 53: 839–847. ArticleCASPubMed Google Scholar
McGuffin P, Farmer A . A polydiagnostic application of operational criteria in studies of psychotic illness: development and validation of the OPCRIT system. Arch Gen Psychiatry 1991; 48: 764–770. ArticleCASPubMed Google Scholar
Castle DJ, Jablensky A, McGrath JJ, Carr V, Morgan V, Waterreus A et al. The diagnostic interview for psychoses (DIP): development, reliability and applications. Psychol Med 2006; 36: 69–80. ArticleCASPubMed Google Scholar
Buchanan RW, Heinrichs DW . The Neurological Evaluation Scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res 1989; 27: 335–350. ArticleCASPubMed Google Scholar
American Psychological Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington, DC, USA, 1994.
Wechsler D . Wechsler Test of Adult Reading (WTAR). The Psychological Corporation: New York, 2001. Google Scholar
Wechsler D . Wechsler Abbreviated Scale of Intelligence (WASI). The Psychological Corporation: New York, 1999. Google Scholar
Randolph C . Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The Psychological Corporation: San Antonio, TX, 1998. Google Scholar
Wechsler D . Wechsler Adult Intelligence Scales, 3rd edn. The Psychological Corporation: New York, 1997. Google Scholar
Spreen O, Strauss E . A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. Oxford University Press: New York, 1998. Google Scholar
Jablensky A, Woodbury MA . Dementia praecox and manic-depressive insanity in 1908: a Grade of Membership analysis of the Kraepelinian dichotomy. Eur Arch Psychiatry Clin Neurosci 1995; 245: 202–209. ArticleCASPubMed Google Scholar
Perkins DO, Jeffries CD, Jarskog LF, Thomson JM, Woods K, Newman MA et al. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Genome Biol 2007; 8: R27. ArticlePubMedPubMed Central Google Scholar
Beveridge NJ, Tooney PA, Carroll AP, Gardiner E, Bowden N, Scott RJ et al. Dysregulation of miRNA 181b in the temporal cortex in schizophrenia. Hum Mol Genet 2008; 17: 1156–1168. ArticleCASPubMed Google Scholar
Beveridge NJ, Gardiner E, Carroll AP, Tooney PA, Cairns MJ . Schizophrenia is associated with an increase in cortical microRNA biogenesis. Molecular Psychiatry 2010; 15: 1176–1189. ArticleCASPubMed Google Scholar
Santarelli DM, Beveridge NJ, Tooney PA, Cairns MJ . Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia. Biol Psychiatry 2011; 69: 180–187. ArticleCASPubMed Google Scholar
Gardiner E, Beveridge NJ, Wu JQ, Carr V, Scott RJ, Tooney PA et al. Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells. Mol Psychiatry advance online publication, 5 July 2011; e-pub ahead of print (doi: 10.1038/mp.2011.78). ArticlePubMedPubMed Central Google Scholar
Schratt G . Fine-tuning neural gene expression with microRNAs. Curr Opin Neurobiol 2009; 19: 213–219. ArticleCASPubMed Google Scholar
Smrt RD, Szulwach KE, Pfeiffer RL, Li X, Guo W, Pathania M et al. MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1. Stem Cells 2010; 28: 1060–1070. ArticleCASPubMedPubMed Central Google Scholar
Willemsen MH, Valles A, Kirkels LAMH, Mastebroek M, Olde Loohuis N, Kos A et al. Chromosome 1p21.3 microdeletions comprising DPYD and MIR137 are associated with intellectual disability. J Med Genet 2011; 48: 810–818. ArticleCASPubMed Google Scholar
Green MJ, Matheson SL, Shepherd A, Weickert CS, Carr VJ . Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Mol Psychiatry 2011; 16: 960–972. ArticleCASPubMed Google Scholar
Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M et al. A brain-specific microRNA regulates dendritic spine development [published erratum appears in Nature 2006; 441:902]. Nature 2006; 439: 283–289. ArticleCASPubMed Google Scholar
Beveridge NJ, Tooney PA, Carroll AP, Tran N, Cairns MJ . Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation. Cell Signal 2009; 21: 1837–1845. ArticleCASPubMed Google Scholar
Bilder RM, Volavka J, Czobor P, Malhotra AK, Kennedy JL, Ni X et al. Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 2002; 52: 701–707. ArticleCASPubMed Google Scholar
Wang Y, Fang Y, Shen Y, Xu Q . Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia. Psychiatry Res 2010; 179: 147–150. ArticleCASPubMed Google Scholar