Stone, D. M. et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature384, 129–134 (1996) ArticleADSCASPubMed Google Scholar
Fuse, N. et al. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc. Natl Acad. Sci. USA96, 10992–10999 (1999) ArticleADSCASPubMedPubMed Central Google Scholar
Ingham, P. W., Taylor, A. M. & Nakano, Y. Role of Drosophila patched gene in positional signaling. Nature353, 184–187 (1991) ArticleADSCASPubMed Google Scholar
Goodrich, L. V., Milenkovic, L., Higgins, K. M. & Scott, M. P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science277, 1109–1113 (1997) ArticleCASPubMed Google Scholar
Ingham, P. W. & McMahon, A. P. Hedgehog signalling in animal development: paradigms and principles. Genes Dev.15, 3059–3087 (2001) ArticleCASPubMed Google Scholar
Ingham, P. W. et al. Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. Curr. Biol.10, 1315–1318 (2000) ArticleCASPubMed Google Scholar
Denef, N., Neubuser, D., Perez, L. & Cohen, S. M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell102, 521–531 (2000) ArticleCASPubMed Google Scholar
Williams, K. P. et al. Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity. J. Cell. Sci.112, 4405–4414 (1999) CASPubMed Google Scholar
Briscoe, J., Chen, Y., Jessell, T. M. & Struhl, G. A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. Mol. Cell7, 1279–1291 (2001) ArticleCASPubMed Google Scholar
Capdevila, J., Pariente, F., Sampedro, J., Alonso, J. L. & Guerrero, I. Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos. Development120, 987–998 (1994) CASPubMed Google Scholar
Dann, C. E. et al. Insights into Wnt binding and signalling from the structures of two frizzled cysteine-rich domains. Nature412, 86–90 (2001) ArticleADSCASPubMed Google Scholar
Alcedo, J., Zou, Y. & Noll, M. Posttranscriptional regulation of Smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Mol. Cell6, 457–465 (2000) ArticleCASPubMed Google Scholar
Tseng, T. T. et al. The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J. Mol. Microbiol. Biotechnol.1, 107–125 (1999) CASPubMed Google Scholar
Davies, J. P., Chen, F. W. & Ioannou, Y. A. Transmembrane molecular pump activity of niemann-pick C1 protein. Science290, 2295–2298 (2000) ArticleADSCASPubMed Google Scholar
Burke, R. et al. Dispatched, a novel sterol sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells. Cell99, 803–815 (1999) ArticleCASPubMed Google Scholar
Goldberg, M., Pribyl, T., Juhnke, S. & Nies, D. S. Energetics and topology of CzcA, a cation/proton antiporter of the resistance-nodulation-cell division protein family. J. Biol. Chem.274, 26065–26070 (1999) ArticleCASPubMed Google Scholar
Guan, L. & Nakae, T. Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa. J. Bacteriol.183, 1734–1739 (2001) ArticleCASPubMedPubMed Central Google Scholar
Chidambaram, A. et al. Mutations in the human homologue of the Drosophila Patched gene in caucasian and African-American nevoid basal cell carcinoma syndrome patients. Cancer Res.56, 4599–4601 (1996) CASPubMed Google Scholar
Wicking, C. et al. Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to premature termination of the Patched protein, and no genotype–phenotype correlations are evident. Am. J. Hum. Genet.60, 21–26 (1997) CASPubMedPubMed Central Google Scholar
Aszterbaum, M. et al. Identification of mutations in the human Patched gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J. Invest. Dermatol.110, 885–888 (1998) ArticleCASPubMed Google Scholar
Taipale, J. et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature406, 1005–1009 (2000) ArticleADSCASPubMed Google Scholar
Zeng, X. et al. A freely diffusible form of Sonic hedgehog mediates long range signalling. Nature411, 716–720 (2001) ArticleADSCASPubMed Google Scholar
Sasaki, H., Hui, C.-c., Nakafuku, M. & Kondoh, H. A binding site for Gli proteins is essential for HNF3β floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development124, 1313–1322 (1997) CASPubMed Google Scholar
Strutt, H. et al. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Curr. Biol.11, 608–613 (2001) ArticleCASPubMed Google Scholar
Martin, V., Carrillo, G., Torroja, C. & Guerrero, I. The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking. Curr. Biol.11, 601–607 (2001) ArticleCASPubMed Google Scholar
Ko, D. C., Gordon, M. D., Jin, J. Y. & Scott, M. P. Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. Mol. Biol. Cell12, 601–614 (2001) ArticleCASPubMedPubMed Central Google Scholar