The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA (original) (raw)
References
Pathak, V. K. & Temin, H. M. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations. Proc. Natl Acad. Sci. USA87, 6019–6023 (1990) ArticleADSCASPubMedPubMed Central Google Scholar
Li, Y. et al. Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes. J. Virol.65, 3973–3985 (1991) CASPubMedPubMed Central Google Scholar
Vartanian, J. P., Meyerhans, A., Asjo, B. & Wain-Hobson, S. Selection, recombination, and G → A hypermutation of human immunodeficiency virus type 1 genomes. J. Virol.65, 1779–1788 (1991) CASPubMedPubMed Central Google Scholar
Vartanian, J. P., Meyerhans, A., Sala, M. & Wain-Hobson, S. G → A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription. Proc. Natl Acad. Sci. USA91, 3092–3096 (1994) ArticleADSCASPubMedPubMed Central Google Scholar
Fitzgibbon, J. E., Mazar, S. & Dubin, D. T. A new type of G → A hypermutation affecting human immunodeficiency virus. AIDS Res. Hum. Retroviruses9, 833–838 (1993) ArticleCASPubMed Google Scholar
Vartanian, J. P., Henry, M. & Wain-Hobson, S. Sustained G → A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome. J. Gen. Virol.83, 801–805 (2002) ArticleCASPubMed Google Scholar
Sheehy, A. M., Gaddis, N. C., Choi, J. D. & Malim, M. H. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature418, 646–650 (2002) ArticleADSCASPubMed Google Scholar
Jarmuz, A. et al. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. Genomics79, 285–296 (2002) ArticleCASPubMed Google Scholar
Strebel, K. et al. The HIV ‘A’ (sor) gene product is essential for virus infectivity. Nature328, 728–730 (1987) ArticleADSCASPubMed Google Scholar
Fisher, A. G. et al. The sor gene of HIV-1 is required for efficient virus transmission in vitro. Science237, 888–893 (1987) ArticleADSCASPubMed Google Scholar
Gabuzda, D. H. et al. Role of vif in replication of human immunodeficiency virus type 1 in CD4 + T lymphocytes. J. Virol.66, 6489–6495 (1992) CASPubMedPubMed Central Google Scholar
Sova, P. & Volsky, D. J. Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with vif-negative human immunodeficiency virus type 1. J. Virol.67, 6322–6326 (1993) CASPubMedPubMed Central Google Scholar
von Schwedler, U., Song, J., Aiken, C. & Trono, D. Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J. Virol.67, 4945–4955 (1993) CASPubMedPubMed Central Google Scholar
Simon, J. H. & Malim, M. H. The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes. J. Virol.70, 5297–5305 (1996) CASPubMedPubMed Central Google Scholar
Zhang, H., Pomerantz, R. J., Dornadula, G. & Sun, Y. Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process. J. Virol.74, 8252–8261 (2000) ArticleCASPubMedPubMed Central Google Scholar
Dettenhofer, M., Cen, S., Carlson, B. A., Kleiman, L. & Yu, X. F. Association of human immunodeficiency virus type 1 Vif with RNA and its role in reverse transcription. J. Virol.74, 8938–8945 (2000) ArticleCASPubMedPubMed Central Google Scholar
Khan, M. A. et al. Human immunodeficiency virus type 1 Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA. J. Virol.75, 7252–7265 (2001) ArticleCASPubMedPubMed Central Google Scholar
Harris, R. S., Petersen-Mahrt, S. K. & Neuberger, M. S. RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol. Cell10, 1247–1253 (2002) ArticleCASPubMed Google Scholar
Petersen-Mahrt, S. K., Harris, R. S. & Neuberger, M. S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature418, 99–103 (2002) ArticleADSCASPubMed Google Scholar
Dornadula, G., Yang, S., Pomerantz, R. J. & Zhang, H. Partial rescue of the vif-negative phenotype of mutant human immunodeficiency virus type 1 strains from nonpermissive cells by intravirion reverse transcription. J. Virol.74, 2594–2602 (2000) ArticleCASPubMedPubMed Central Google Scholar
Janini, M., Rogers, M., Birx, D. R. & McCutchan, F. E. Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4(+ ) T cells. J. Virol.75, 7973–7986 (2001) ArticleCASPubMedPubMed Central Google Scholar
Kao, S. et al. Human immunodeficiency virus type 1 Vif is efficiently packaged into virions during productive but not chronic infection. J. Virol.77, 1131–1140 (2003) ArticleCASPubMedPubMed Central Google Scholar
Chester, A., Scott, J., Anant, S. & Navaratnam, N. RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA. Biochim. Biophys. Acta1494, 1–13 (2000) ArticleCASPubMed Google Scholar
Mehta, A., Banerjee, S. & Driscoll, D. M. Apobec-1 interacts with a 65-kDa complementing protein to edit apolipoprotein-B mRNA in vitro. J. Biol. Chem.271, 28294–28299 (1996) ArticleCASPubMed Google Scholar
Martinez, M. A., Vartanian, J. P. & Wain-Hobson, S. Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations. Proc. Natl Acad. Sci. USA91, 11787–11791 (1994) ArticleADSCASPubMedPubMed Central Google Scholar
Vartanian, J. P. et al. HIV genetic variation is directed and restricted by DNA precursor availability. J. Mol. Biol.270, 139–151 (1997) ArticleCASPubMed Google Scholar
Zhang, H., Dornadula, G. & Pomerantz, R. J. Endogenous reverse transcription of human immunodeficiency virus type 1 in physiological microenvironments: an important stage for viral infection of nondividing cells. J. Virol.70, 2809–2824 (1996) CASPubMedPubMed Central Google Scholar
MacGinnitie, A. J., Anant, S. & Davidson, N. O. Mutagenesis of apobec-1, the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme, reveals distinct domains that mediate cytosine nucleoside deaminase, RNA binding, and RNA editing activity. J. Biol. Chem.270, 14768–14775 (1995) ArticleCASPubMed Google Scholar