MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer (original) (raw)
Nowak, A. K., Chow, P. K. & Findlay, M. Systemic therapy for advanced hepatocellular carcinoma: a review. Eur. J. Cancer40, 1474–1484 (2004) ArticleCAS Google Scholar
Felsher, D. W. Cancer revoked: oncogenes as therapeutic targets. Nature Rev. Cancer3, 375–380 (2003) ArticleADSCAS Google Scholar
Jain, M. et al. Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science297, 102–104 (2002) ArticleADSCAS Google Scholar
Coleman, W. B. Mechanisms of human hepatocarcinogenesis. Curr. Mol. Med.3, 573–588 (2003) ArticleCAS Google Scholar
Sandgren, E. P., Quaife, C. J., Pinkert, C. A., Palmiter, R. D. & Brinster, R. L. Oncogene-induced liver neoplasia in transgenic mice. Oncogene4, 715–724 (1989) CASPubMed Google Scholar
Murakami, H. et al. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res.53, 1719–1723 (1993) CASPubMed Google Scholar
Wu, Y. et al. Recurrent allelic deletions at mouse chromosomes 4 and 14 in Myc-induced liver tumors. Oncogene21, 1518–1526 (2002) ArticleCAS Google Scholar
Simile, M. M. et al. Downregulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells. Carcinogenesis25, 333–334 (2003) Article Google Scholar
Kistner, A. et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc. Natl Acad. Sci. USA93, 10933–10938 (1996) ArticleADSCAS Google Scholar
Felsher, D. W. & Bishop, J. M. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell4, 199–207 (1999) ArticleCAS Google Scholar
Venook, A. P. Hepatocellular carcinoma. Curr. Treat. Options Oncol.1, 407–415 (2000) ArticleCAS Google Scholar
Thorgeirsson, S. S. Hepatic stem cells in liver regeneration. FASEB J.10, 1249–1256 (1996) ArticleCAS Google Scholar
Fausto, N. Hepatocyte differentiation and liver progenitor cells. Curr. Opin. Cell Biol.2, 1036–1042 (1990) ArticleCAS Google Scholar
Fausto, N. & Campbell, J. S. The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech. Dev.120, 117–130 (2003) ArticleCAS Google Scholar
Hardy, J. et al. Bioluminescence imaging of lymphocyte trafficking in vivo. Exp. Hematol.29, 1353–1360 (2001) ArticleCAS Google Scholar
Uhr, J. W., Tucker, T., May, R. D., Siu, H. & Vitetta, E. S. Cancer dormancy: studies of the murine BCL1 lymphoma. Cancer Res.51, 5045s–5053s (1991) CASPubMed Google Scholar
Demicheli, R. Tumour dormancy: findings and hypotheses from clinical research on breast cancer. Semin. Cancer Biol.11, 297–306 (2001) ArticleCAS Google Scholar
Naumov, G. N., MacDonald, I. C., Chambers, A. F. & Groom, A. C. Solitary cancer cells as a possible source of tumour dormancy? Semin. Cancer Biol.11, 271–276 (2001) ArticleCAS Google Scholar
Uhr, J. W., Scheuermann, R. H., Street, N. E. & Vitetta, E. S. Cancer dormancy: opportunities for new therapeutic approaches. Nature Med.3, 505–509 (1997) ArticleCAS Google Scholar
Riethmuller, G. & Klein, C. A. Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients. Semin. Cancer Biol.11, 307–311 (2001) ArticleCAS Google Scholar
Holmgren, L., O'Reilly, M. S. & Folkman, J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med.1, 149–153 (1995) ArticleCAS Google Scholar
Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature414, 105–111 (2001) ArticleADSCAS Google Scholar
Willert, K. et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature423, 448–452 (2003) ArticleADSCAS Google Scholar
Al-Hajj, M. B., Wicha, M. W., Weissman, M. & Clarke, I. M. F. Therapeutic implications of cancer stem cells. Curr. Opin. Genet. Dev.14, 43–47 (2004) ArticleCAS Google Scholar
Laird, P. W. et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell81, 197–205 (1995) ArticleCAS Google Scholar
Lotem, J. & Sachs, L. Epigenetics wins over genetics: induction of differentiation in tumor cells. Semin. Cancer Biol.12, 339–346 (2002) ArticleCAS Google Scholar
Leffert, K. S. & Skelly, K. in Cell Culture Methods for Molecular and Cell Biology (eds Barnes, D. W., Sirbasku, D. A. & Sato, G. H.) 43–55 (Alan R. Liss, New York, 1984) Google Scholar
Edinger, M. et al. Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging. Blood101, 640–648 (2003) ArticleCAS Google Scholar
Pollack, J. R. et al. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nature Genet.23, 41–46 (1999) ArticleCAS Google Scholar