The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells (original) (raw)

• Ye, B. H. et al. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 262, 747–750 (1993)
  Article ADS CAS Google Scholar
• Ye, B. H. et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nature Genet. 16, 161–170 (1997)
  Article CAS Google Scholar
• Dent, A. L., Shaffer, A. L., Yu, X., Allman, D. & Staudt, L. M. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276, 589–592 (1997)
  Article CAS Google Scholar
• Shaffer, A. L. et al. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 13, 199–212 (2000)
  Article CAS Google Scholar
• Niu, H., Cattoretti, G. & Dalla-Favera, R. BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells. J. Exp. Med. 198, 211–221 (2003)
  Article CAS Google Scholar
• Pasqualucci, L. et al. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood 101, 2914–2923 (2003)
  Article CAS Google Scholar
• Tunyaplin, C. et al. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J. Immunol. 173, 1158–1165 (2004)
  Article CAS Google Scholar
• Cattoretti, G. et al. BCL-6 protein is expressed in germinal-center B cells. Blood 86, 45–53 (1995)
  CAS Google Scholar
• MacLennan, I. C. Germinal centers. Annu. Rev. Immunol. 12, 117–139 (1994)
  Article CAS Google Scholar
• Rajewsky, K. Clonal selection and learning in the antibody system. Nature 381, 751–758 (1996)
  Article ADS CAS Google Scholar
• Ye, B. H. et al. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO. J. 14, 6209–6217 (1995)
  Article CAS Google Scholar
• el-Deiry, W. S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817–825 (1993)
  Article CAS Google Scholar
• Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307–310 (2000)
  Article ADS CAS Google Scholar
• Papavasiliou, F. N. & Schatz, D. G. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature 408, 216–221 (2000)
  Article ADS CAS Google Scholar
• Sale, J. E. & Neuberger, M. S. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 9, 859–869 (1998)
  Article CAS Google Scholar
• Bross, L. et al. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation. Immunity 13, 589–597 (2000)
  Article CAS Google Scholar
• Chang, C. C., Ye, B. H., Chaganti, R. S. & Dalla-Favera, R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl Acad. Sci. USA 93, 6947–6952 (1996)
  Article ADS CAS Google Scholar
• Takaoka, A. et al. Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 424, 516–523 (2003)
  Article ADS CAS Google Scholar
• Kurosu, T., Fukuda, T., Miki, T. & Miura, O. BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells. Oncogene 22, 4459–4468 (2003)
  Article CAS Google Scholar
• Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W. & Vogelstein, B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7, 673–682 (2001)
  Article CAS Google Scholar
• Storb, U. The molecular basis of somatic hypermutation of immunoglobulin genes. Curr. Opin. Immunol. 8, 206–214 (1996)
  Article CAS Google Scholar
• Honjo, T., Kinoshita, K. & Muramatsu, M. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol. 20, 165–196 (2002)
  Article CAS Google Scholar
• Chen, X., Kinoshita, K. & Honjo, T. Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination. Proc. Natl Acad. Sci. USA 98, 13860–13865 (2001)
  Article ADS CAS Google Scholar
• Lo Coco, F. et al. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 83, 1757–1759 (1994)
  CAS Google Scholar
• Migliazza, A. et al. Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. Proc. Natl Acad. Sci. USA 92, 12520–12524 (1995)
  Article ADS CAS Google Scholar
• Offit, K. et al. BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma. Leuk. Lymphoma 20, 85–89 (1995)
  Article CAS Google Scholar
• Gaidano, G. et al. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 88, 5413–5417 (1991)
  Article ADS CAS Google Scholar
• Lo Coco, F. et al. p53 mutations are associated with histologic transformation of follicular lymphoma. Blood 82, 2289–2295 (1993)
  CAS PubMed Google Scholar
• Bereshchenko, O. R., Gu, W. & Dalla-Favera, R. Acetylation inactivates the transcriptional repressor BCL6. Nature Genet. 32, 606–613 (2002)
  Article CAS Google Scholar