Structure and different conformational states of native AMPA receptor complexes (original) (raw)

References

  1. Malinow, R. & Malenka, R. C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25, 103–126 (2002)
    Article CAS Google Scholar
  2. Wollmuth, L. P. & Sobolevsky, A. I. Structure and gating of the glutamate receptor ion channel. Trends Neurosci. 27, 321–328 (2004)
    Article CAS Google Scholar
  3. Tichelaar, W., Safferling, M., Keinanen, K., Stark, H. & Madden, D. R. The Three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly. J. Mol. Biol. 344, 435–442 (2004)
    Article CAS Google Scholar
  4. Keinanen, K. et al. A family of AMPA-selective glutamate receptors. Science 249, 556–560 (1990)
    Article ADS CAS Google Scholar
  5. Hollmann, M., O'Shea-Greenfield, A., Rogers, S. W. & Heinemann, S. Cloning by functional expression of a member of the glutamate receptor family. Nature 342, 643–648 (1989)
    Article ADS CAS Google Scholar
  6. Safferling, M. et al. First images of a glutamate receptor ion channel: oligomeric state and molecular dimensions of GluRB homomers. Biochemistry 40, 13948–13953 (2001)
    Article CAS Google Scholar
  7. Rosenmund, C., Stern-Bach, Y. & Stevens, C. F. The tetrameric structure of a glutamate receptor channel. Science 280, 1596–1599 (1998)
    Article ADS CAS Google Scholar
  8. Chen, G. Q., Cui, C., Mayer, M. L. & Gouaux, E. Functional characterization of a potassium-selective prokaryotic glutamate receptor. Nature 402, 817–821 (1999)
    Article ADS CAS Google Scholar
  9. Wenthold, R. J., Petralia, R. S., Blahos, J. II & Niedzielski, A. S. Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons. J. Neurosci. 16, 1982–1989 (1996)
    Article CAS Google Scholar
  10. Armstrong, N. & Gouaux, E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron 28, 165–181 (2000)
    Article CAS Google Scholar
  11. Sobolevsky, A. I., Yelshansky, M. V. & Wollmuth, L. P. The outer pore of the glutamate receptor channel has 2-fold rotational symmetry. Neuron 41, 367–378 (2004)
    Article CAS Google Scholar
  12. Horning, M. S. & Mayer, M. L. Regulation of AMPA receptor gating by ligand binding core dimers. Neuron 41, 379–388 (2004)
    Article CAS Google Scholar
  13. Stern-Bach, Y. et al. Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron 13, 1345–1357 (1994)
    Article CAS Google Scholar
  14. Hollmann, M., Maron, C. & Heinemann, S. N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1. Neuron 13, 1331–1343 (1994)
    Article CAS Google Scholar
  15. Bennett, J. A. & Dingledine, R. Topology profile for a glutamate receptor: three transmembrane domains and a channel-lining reentrant membrane loop. Neuron 14, 373–384 (1995)
    Article CAS Google Scholar
  16. Ohi, M., Li, Y., Cheng, Y. & Walz, T. Negative staining and image classification—powerful tools in modern electron microscopy. Biol. Proc. Online 6, 23–34 (2004)
    Article CAS Google Scholar
  17. Frank, J. Three-dimensional Electron Microscopy of Macromolecular Assemblies (Academic, San Diego, 1996)
    Google Scholar
  18. Kunishima, N. et al. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407, 971–977 (2000)
    Article ADS CAS Google Scholar
  19. Armstrong, N., Sun, Y., Chen, G. Q. & Gouaux, E. Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature 395, 913–917 (1998)
    Article ADS CAS Google Scholar
  20. Sun, Y. et al. Mechanism of glutamate receptor desensitization. Nature 417, 245–253 (2002)
    Article ADS CAS Google Scholar
  21. Doyle, D. A. et al. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280, 69–77 (1998)
    Article ADS CAS Google Scholar
  22. Chen, L. et al. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408, 936–943 (2000)
    Article ADS CAS Google Scholar
  23. Tomita, S., Fukata, M., Nicoll, R. A. & Bredt, D. S. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science 303, 1508–1511 (2004)
    Article ADS CAS Google Scholar
  24. Patneau, D. K., Vyklicky, L. Jr & Mayer, M. L. Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. J. Neurosci. 13, 3496–3509 (1993)
    Article CAS Google Scholar
  25. Sommer, B. et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science 249, 1580–1585 (1990)
    Article ADS CAS Google Scholar
  26. Swanson, G. T., Kamboj, S. K. & Cull-Candy, S. G. Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition. J. Neurosci. 17, 58–69 (1997)
    Article CAS Google Scholar
  27. Goodsell, D. S. & Olson, A. J. Structural symmetry and protein function. Annu. Rev. Biophys. Biomol. Struct. 29, 105–153 (2000)
    Article CAS Google Scholar
  28. Pasternack, A. et al. Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain. J. Biol. Chem. 277, 49662–49667 (2002)
    Article CAS Google Scholar
  29. Ayalon, G. & Stern-Bach, Y. Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions. Neuron 31, 103–113 (2001)
    Article CAS Google Scholar
  30. Passafaro, M., Nakagawa, T., Sala, C. & Sheng, M. Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2. Nature 424, 677–681 (2003)
    Article ADS CAS Google Scholar

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