Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivity (original) (raw)

References

  1. Irvine, D. J., Purbhoo, M. A., Krogsgaard, M. & Davis, M. M. Direct observation of ligand recognition by T cells. Nature 419, 845–849 (2002)
    Article ADS CAS Google Scholar
  2. Purbhoo, M. A., Irvine, D. J., Huppa, J. B. & Davis, M. M. T cell killing does not require the formation of a stable mature immunological synapse. Nature Immunol. 5, 524–530 (2004)
    Article CAS Google Scholar
  3. Boniface, J. J. et al. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity 9, 459–466 (1998); erratum 9, 891
    Article CAS Google Scholar
  4. Cochran, J. R., Cameron, T. O. & Stern, L. J. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity 12, 241–250 (2000)
    Article CAS Google Scholar
  5. Tanchot, C., Lemonnier, F. A., Perarnau, B., Freitas, A. A. & Rocha, B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276, 2057–2062 (1997)
    Article CAS Google Scholar
  6. Ernst, B., Lee, D. S., Chang, J. M., Sprent, J. & Surh, C. D. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11, 173–181 (1999)
    Article CAS Google Scholar
  7. Stefanova, I., Dorfman, J. R. & Germain, R. N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420, 429–434 (2002)
    Article ADS CAS Google Scholar
  8. Wulfing, C. et al. Costimulation and endogenous MHC ligands contribute to T cell recognition. Nature Immunol. 3, 42–47 (2002)
    Article CAS Google Scholar
  9. Sporri, R. & Reis e Sousa, C. Self peptide/MHC class I complexes have a negligible effect on the response of some CD8 + T cells to foreign antigen. Eur. J. Immunol. 32, 3161–3170 (2002)
    Article CAS Google Scholar
  10. Davis, M. M. et al. Ligand recognition by αβT cell receptors. Annu. Rev. Immunol. 16, 523–544 (1998)
    Article ADS CAS Google Scholar
  11. Marrack, P., Ignatowicz, L., Kappler, J. W., Boymel, J. & Freed, J. H. Comparison of peptides bound to spleen and thymus class II. J. Exp. Med. 178, 2173–2183 (1993)
    Article CAS Google Scholar
  12. Schild, H. et al. Natural ligand motifs of H-2E molecules are allele specific and illustrate homology to HLA-DR molecules. Int. Immunol. 7, 1957–1965 (1995)
    Article CAS Google Scholar
  13. Lee, S. J., Hori, Y., Groves, J. T., Dustin, M. L. & Chakraborty, A. K. Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. Trends Immunol. 23, 492–499 (2002)
    Article CAS Google Scholar
  14. Tsien, R. Y. Fluorescent probes of cell signaling. Annu. Rev. Neurosci. 12, 227–253 (1989)
    Article CAS Google Scholar
  15. Li, Q. J. et al. CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nature Immunol. 5, 791–799 (2004)
    Article CAS Google Scholar
  16. Deane, J. A. & Fruman, D. A. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu. Rev. Immunol. 22, 563–598 (2004)
    Article CAS Google Scholar
  17. Huppa, J. B., Gleimer, M., Sumen, C. & Davis, M. M. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nature Immunol. 4, 749–755 (2003)
    Article CAS Google Scholar
  18. Wettstein, D. A., Boniface, J. J., Reay, P. A., Schild, H. & Davis, M. M. Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH. J. Exp. Med. 174, 219–228 (1991)
    Article CAS Google Scholar
  19. Schild, H. et al. The nature of major histocompatibility complex recognition by gamma delta T cells. Cell 76, 29–37 (1994)
    Article CAS Google Scholar
  20. Sumen, C., Dustin, M. L. & Davis, M. M. T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation. J. Cell Biol. 166, 579–590 (2004)
    Article CAS Google Scholar
  21. Miceli, M. C. & Parnes, J. R. Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol. 53, 59–122 (1993)
    Article CAS Google Scholar
  22. Konig, R., Huang, L. Y. & Germain, R. N. MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature 356, 796–798 (1992)
    Article ADS CAS Google Scholar
  23. Cammarota, G. et al. Identification of a CD4 binding site on the β2 domain of HLA-DR molecules. Nature 356, 799–801 (1992)
    Article ADS CAS Google Scholar
  24. Wu, L. C., Tuot, D. S., Lyons, D. S., Garcia, K. C. & Davis, M. M. Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature 418, 552–556 (2002)
    Article ADS CAS Google Scholar
  25. Delon, J. et al. CD8 expression allows T cell signaling by monomeric peptide-MHC complexes. Immunity 9, 467–473 (1998)
    Article CAS Google Scholar
  26. Ge, Q. et al. Soluble peptide-MHC monomers cause activation of CD8 + T cells through transfer of the peptide to T cell MHC molecules. Proc. Natl Acad. Sci. USA 99, 13729–13734 (2002)
    Article ADS CAS Google Scholar
  27. Aivazian, D. & Stern, L. J. Phosphorylation of T cell receptor ζ is regulated by a lipid dependent folding transition. Nature Struct. Biol. 7, 1023–1026 (2000)
    Article CAS Google Scholar
  28. Sun, Z. J., Kim, K. S., Wagner, G. & Reinherz, E. L. Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3ɛγ heterodimer. Cell 105, 913–923 (2001)
    Article CAS Google Scholar
  29. Krogsgaard, M. et al. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation. Mol. Cell 12, 1367–1378 (2003)
    Article CAS Google Scholar
  30. Fremont, D. H., Hendrickson, W. A., Marrack, P. & Kappler, J. Structures of an MHC class II molecule with covalently bound single peptides. Science 272, 1001–1004 (1996)
    Article ADS CAS Google Scholar

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