IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation (original) (raw)

• Lawrence, T., Willoughby, D. A. & Gilroy, D. W. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nature Rev. Immunol. 2, 787–795 (2002)
  Article CAS Google Scholar
• Bonizzi, G. & Karin, M. The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25, 280–288 (2004)
  Article CAS Google Scholar
• Karin, M. & Ben-Neriah, Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18, 621–663 (2000)
  Article CAS Google Scholar
• Hoffmann, A., Levchenko, A., Scott, M. L. & Baltimore, D. The IκB-NF-κB signaling module: temporal control and selective gene activation. Science 298, 1241–1245 (2002)
  Article ADS CAS Google Scholar
• Wertz, I. E. et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling. Nature 430, 694–699 (2004)
  Article ADS CAS Google Scholar
• Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell 109 (suppl.), S81–S96 (2002)
  Article CAS Google Scholar
• Makris, C. et al. Female mice heterozygous for IKKγ/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol. Cell 5, 969–979 (2000)
  Article CAS Google Scholar
• Dejardin, E. et al. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-κB pathways. Immunity 17, 525–535 (2002)
  Article CAS Google Scholar
• Senftleben, U. et al. Activation by IKKα of a second, evolutionary conserved, NF-κ B signaling pathway. Science 293, 1495–1499 (2001)
  Article ADS CAS Google Scholar
• Anest, V. et al. A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression. Nature 423, 659–663 (2003)
  Article ADS CAS Google Scholar
• Yamamoto, Y., Verma, U. N., Prajapati, S., Kwak, Y. T. & Gaynor, R. B. Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression. Nature 423, 655–659 (2003)
  Article ADS CAS Google Scholar
• Liu, G. Y. et al. Sword and shield: Linked group B streptococcal β-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense. Proc. Natl Acad. Sci. USA 101, 14491–14496 (2004)
  Article ADS CAS Google Scholar
• Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443–451 (1999)
  Article CAS Google Scholar
• Underhill, D. M. et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401, 811–815 (1999)
  Article ADS CAS Google Scholar
• Bonizzi, G. et al. Activation of IKKα target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J. 23, 4202–4210 (2004)
  Article CAS Google Scholar
• Gordon, S. Pattern recognition receptors: doubling up for the innate immune response. Cell 111, 927–930 (2002)
  Article CAS Google Scholar
• Park, J. M., Greten, F. R., Li, Z. W. & Karin, M. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297, 2048–2051 (2002)
  Article ADS CAS Google Scholar
• Puliti, M., von Hunolstein, C., Bistoni, F., Orefici, G. & Tissi, L. Inhibition of nitric oxide synthase exacerbates group B streptococcus sepsis and arthritis in mice. Infect. Immun. 72, 4891–4894 (2004)
  Article CAS Google Scholar
• Sakurai, H. et al. Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J. Biol. Chem. 278, 36916–36923 (2003)
  Article CAS Google Scholar
• Martin, A. G. & Fresno, M. Tumor necrosis factor-alpha activation of NF-κB requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel. J. Biol. Chem. 275, 24383–24391 (2000)
  Article CAS Google Scholar
• Fognani, C., Rondi, R., Romano, A. & Blasi, F. cRel-TD kinase: a serine/threonine kinase binding in vivo and in vitro c-Rel and phosphorylating its transactivation domain. Oncogene 19, 2224–2232 (2000)
  Article CAS Google Scholar
• Salghetti, S. E., Muratani, M., Wijnen, H., Futcher, B. & Tansey, W. P. Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis. Proc. Natl Acad. Sci. USA 97, 3118–3123 (2000)
  Article ADS CAS Google Scholar
• Perissi, V., Aggarwal, A., Glass, C. K., Rose, D. W. & Rosenfeld, M. G. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 116, 511–526 (2004)
  Article CAS Google Scholar
• Saccani, S., Marazzi, I., Beg, A. A. & Natoli, G. Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor κB response. J. Exp. Med. 200, 107–113 (2004)
  Article CAS Google Scholar
• Ryo, A. et al. Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol. Cell 12, 1413–1426 (2003)
  Article CAS Google Scholar
• Chen, E. et al. Degradation of proto-oncoprotein c-Rel by the ubiquitin-proteasome pathway. J. Biol. Chem. 273, 35201–35207 (1998)
  Article CAS Google Scholar
• Weih, F. et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80, 331–340 (1995)
  Article CAS Google Scholar
• Saccani, S., Pantano, S. & Natoli, G. Modulation of NF-κB activity by exchange of dimers. Mol. Cell 11, 1563–1574 (2003)
  Article CAS Google Scholar
• Sun, S. C., Ganchi, P. A., Ballard, D. W. & Greene, W. C. NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway. Science 259, 1912–1915 (1993)
  Article ADS CAS Google Scholar
• Ducut Sigala, J. L. et al. Activation of transcription factor NF-κB requires ELKS, an IκB kinase regulatory subunit. Science 304, 1963–1967 (2004)
  Article ADS CAS Google Scholar